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dc.creatorSmyk, D.en
dc.creatorRigopoulou, E. I.en
dc.creatorBaum, H.en
dc.creatorBurroughs, A. K.en
dc.creatorVergani, D.en
dc.creatorBogdanos, D. P.en
dc.date.accessioned2015-11-23T10:47:34Z
dc.date.available2015-11-23T10:47:34Z
dc.date.issued2012
dc.identifier10.1007/s12016-011-8259-x
dc.identifier.issn1080-0549
dc.identifier.urihttp://hdl.handle.net/11615/33109
dc.description.abstractThe complex interplay between environmental factors and genetic susceptibility plays an essential role in disease pathogenesis. This is especially true for autoimmunity, where clinical reports, genomic and epidemiological studies, as well as animal models have identified several environmental and genetic risk factors associated with autoimmune disease. The complexity of this relationship is demonstrated by the vast array of environmental factors that have now been implicated in the induction, and possibly the maintenance of autoimmune disease. The multitude of environmental factors implicated includes both infectious and non-infectious agents. Here, we review one specific autoimmune disease, primary biliary cirrhosis (PBC), as a model for environmental risk factors acting in concert with genetic susceptibility in the disease pathogenesis. PBC is an ideal model, as both infectious and non-infectious environmental agents have been identified as risk factors, and their study provides clues for unravelling the pathogenesis of the disease.en
dc.source.uri<Go to ISI>://WOS:000301569400011
dc.subjectAMAen
dc.subjectGeneticsen
dc.subjectEstrogenen
dc.subjectPBCen
dc.subjectRisk factorsen
dc.subjectUrinary tract infectionsen
dc.subjectXenobioticsen
dc.subjectPRIMARY BILIARY-CIRRHOSISen
dc.subjectSYSTEMIC-LUPUS-ERYTHEMATOSUSen
dc.subjectHEPATITIS-Cen
dc.subjectVIRUSen
dc.subjectIMMUNOLOGICAL CROSS-REACTIVITYen
dc.subjectT-CELL EPITOPEen
dc.subjectURINARY-TRACT-INFECTIONen
dc.subjectANTIMITOCHONDRIAL ANTIBODIESen
dc.subjectMOLECULARen
dc.subjectMIMICRYen
dc.subjectLIVER-DISEASEen
dc.subjectPYRUVATE-DEHYDROGENASEen
dc.subjectAllergyen
dc.subjectImmunologyen
dc.titleAutoimmunity and Environment: Am I at risk?en
dc.typejournalArticleen


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