dc.creator | Simeoforidou, M. | en |
dc.creator | Vretzakis, G. | en |
dc.creator | Bareka, M. | en |
dc.creator | Chantzi, E. | en |
dc.creator | Flossos, A. | en |
dc.creator | Giannoukas, A. | en |
dc.creator | Tsilimingas, N. | en |
dc.date.accessioned | 2015-11-23T10:47:20Z | |
dc.date.available | 2015-11-23T10:47:20Z | |
dc.date.issued | 2011 | |
dc.identifier | 10.1053/j.jvca.2010.08.003 | |
dc.identifier.issn | 1053-0770 | |
dc.identifier.uri | http://hdl.handle.net/11615/33023 | |
dc.description.abstract | Objective: To investigate the impact of 2 postoperative analgesic regimens on heart rate variability in patients who underwent thoracotomy. Design: A prospective, randomized trial. Setting: A single-institutional study in a university hospital. Participants: Fifty patients who underwent thoracotomy under combined general anesthesia and thoracic epidural analgesia divided by a number generator into 2 equal groups (A and B). Interventions: In group A, postoperative analgesia consisted of thoracic epidural analgesia with levobupivacaine for 6 postoperative days. In group B, on the 3rd postoperative day this regimen was changed to patient-controlled intravenous morphine. Heart rate variability recordings were performed on the day before surgery, after the epidural, after operation, and on every postoperative day. Statistical analysis used chi-square and Student t tests (Bonferroni correction). Measurements and Main Results: In both groups, the low-frequency component of the analyzed recordings declined after epidural and after surgery. In group A, the low-frequency component was significantly lower compared with baseline from the 2nd postoperative day onward, whereas in group B it was significantly higher compared with A on the 4th and 6th postoperative days. In both groups, the changes in high frequency were statistically insignificant. Intergroup comparisons of the low-/high-frequency ratio showed statistical difference on the last day of observation. There was no difference between the groups in hemodynamic variables and visual analog scale/10 scores. Conclusions: Postoperatively decreased cardiac sympathetic outflow continues with epidural analgesia, whereas it is abolished by the change to intravenous patient-controlled morphine. (C) 2011 Elsevier Inc. All rights reserved. | en |
dc.source | Journal of Cardiothoracic and Vascular Anesthesia | en |
dc.source.uri | <Go to ISI>://WOS:000295564800012 | |
dc.subject | thoracic | en |
dc.subject | epidural | en |
dc.subject | anesthesia | en |
dc.subject | analgesia | en |
dc.subject | surgery | en |
dc.subject | heart rate | en |
dc.subject | variability | en |
dc.subject | sympathetic | en |
dc.subject | pain | en |
dc.subject | atrial fibrillation | en |
dc.subject | HEART-RATE-VARIABILITY | en |
dc.subject | PULMONARY RESECTION | en |
dc.subject | ATRIAL-FIBRILLATION | en |
dc.subject | SPINAL-ANESTHESIA | en |
dc.subject | THORACOTOMY | en |
dc.subject | FREQUENCY | en |
dc.subject | Anesthesiology | en |
dc.subject | Cardiac & Cardiovascular Systems | en |
dc.subject | Respiratory System | en |
dc.subject | Peripheral Vascular Disease | en |
dc.title | Thoracic Epidural Analgesia With Levobupivacaine for 6 Postoperative Days Attenuates Sympathetic Activation After Thoracic Surgery | en |
dc.type | journalArticle | en |