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A multicentre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosis

dc.creatorRuhwald, M.en
dc.creatorDominguez, J.en
dc.creatorLatorre, I.en
dc.creatorLosi, M.en
dc.creatorRicheldi, L.en
dc.creatorPasticci, M. B.en
dc.creatorMazzolla, R.en
dc.creatorGoletti, D.en
dc.creatorButera, O.en
dc.creatorBruchfeld, J.en
dc.creatorGaines, H.en
dc.creatorGerogianni, I.en
dc.creatorTuuminen, T.en
dc.creatorFerrara, G.en
dc.creatorEugen-Olsen, J.en
dc.creatorRavn, P.en
dc.date.accessioned2015-11-23T10:46:41Z
dc.date.available2015-11-23T10:46:41Z
dc.date.issued2011
dc.identifier10.1016/j.tube.2011.01.001
dc.identifier.issn14729792
dc.identifier.urihttp://hdl.handle.net/11615/32734
dc.description.abstractIP-10 has potential as a diagnostic marker for infection with Mycobacterium tuberculosis, with comparable accuracy to QuantiFERON-TB Gold In-Tube test (QFT-IT). The aims were to assess the sensitivity and specificity of IP-10, and to evaluate the impact of co-morbidity on IP-10 and QFT-IT. 168 cases with active TB, 101 healthy controls and 175 non-TB patients were included. IP-10 and IFN-γ were measured in plasma of QFT-IT stimulated whole blood and analyzed using previously determined algorithms. A subgroup of 48 patients and 70 healthy controls was tested in parallel with T-SPOT.TB IP-10 and QFT-IT had comparable accuracy. Sensitivity was 81% and 84% with a specificity of 97% and 100%, respectively. Combining IP-10 and QFT-IT improved sensitivity to 87% (p < 0.0005), with a specificity of 97%. T-SPOT.TB was more sensitive than QFT-IT, but not IP-10. Among non-TB patients IP-10 had a higher rate of positive responders (35% vs 27%, p < 0.02) and for both tests a positive response was associated with relevant risk factors. IFN-γ but not IP-10 responses to mitogen stimulation were reduced in patients with TB and non-TB infection. This study confirms and validates previous findings and adds substance to IP-10 as a novel diagnostic marker for infection with M. tuberculosis. IP-10 appeared less influenced by infections other than TB; further studies are needed to test the clinical impact of these findings. © 2011 Elsevier Ltd. All rights reserved.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-79955695160&partnerID=40&md5=48872fe84f8a9786a0fa370155f91fba
dc.subjectESAT-6 proteinen
dc.subjectInterferon-gammaen
dc.subjectM. tuberculosisen
dc.subjectMitogenen
dc.subjectgamma interferonen
dc.subjectgamma interferon inducible protein 10en
dc.subjectadulten
dc.subjectageden
dc.subjectalgorithmen
dc.subjectarticleen
dc.subjectblooden
dc.subjectclinical articleen
dc.subjectcomorbidityen
dc.subjectcontrolled studyen
dc.subjectdiagnostic accuracyen
dc.subjectdiagnostic testen
dc.subjectextrapulmonary tuberculosisen
dc.subjectfemaleen
dc.subjecthumanen
dc.subjectlung tuberculosisen
dc.subjectmaleen
dc.subjectMycobacterium tuberculosisen
dc.subjectoutcome assessmenten
dc.subjectpriority journalen
dc.subjectQuantiFERON TB Gold In Tube testen
dc.subjectrisk factoren
dc.subjectsensitivity and specificityen
dc.subjecttask performanceen
dc.subjectAdolescenten
dc.subjectAged, 80 and overen
dc.subjectAlgorithmsen
dc.subjectBiological Markersen
dc.subjectChemokine CXCL10en
dc.subjectDenmarken
dc.subjectHumansen
dc.subjectItalyen
dc.subjectMiddle Ageden
dc.subjectSpainen
dc.subjectTuberculin Testen
dc.subjectTuberculosisen
dc.subjectYoung Adulten
dc.titleA multicentre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosisen
dc.typejournalArticleen


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