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dc.creatorPliaka, V.en
dc.creatorKyriakopoulou, Z.en
dc.creatorMarkoulatos, P.en
dc.date.accessioned2015-11-23T10:45:48Z
dc.date.available2015-11-23T10:45:48Z
dc.date.issued2012
dc.identifier10.1586/erv.12.28
dc.identifier.issn1476-0584
dc.identifier.urihttp://hdl.handle.net/11615/32342
dc.description.abstractThe Global Polio Eradication Initiative was launched in 1988 with the aim to eliminate paralytic poliomyelitis. Two effective vaccines are available: inactivated polio vaccine (IPV) and oral polio vaccine (OPV). Since 1964, OPV has been used instead of IPV in most countries due to several economic and biological advantages. However, in rare cases, the live-attenuated Sabin strains of OPV revert to neurovirulence and cause vaccine-associated paralytic poliomyelitis in vaccinees or lead to emergence of vaccine-derived poliovirus strains. Attenuating mutations and recombination events have been associated with the reversion of vaccine strains to neurovirulence. The substitution of OPV with an improved new-generation IPV and the availability of new specific drugs against polioviruses are considered as future strategies for outbreak control and the eradication of paralytic poliomyelitis worldwide.en
dc.sourceExpert Review of Vaccinesen
dc.source.uri<Go to ISI>://WOS:000306542200015
dc.subjectimmunization schedulesen
dc.subjectinactivated polio vaccineen
dc.subjectmutationsen
dc.subjectneurovirulenceen
dc.subjectoral polio vaccineen
dc.subjectrecombinationen
dc.subjectvaccine-associateden
dc.subjectparalytic poliomyelitisen
dc.subjectvaccine-derived poliovirusesen
dc.subjectDEPENDENT RNA-POLYMERASEen
dc.subjectSABIN TYPE-1 POLIOVIRUSen
dc.subjectRHINOVIRUS 3Cen
dc.subjectPROTEASEen
dc.subjectIMMUNODEFICIENT PATIENTen
dc.subjectENHANCED-POTENCYen
dc.subjectVIRUS-VACCINESen
dc.subjectTEMPERATURE SENSITIVITYen
dc.subjectUNITED-STATESen
dc.subjectCODING REGIONen
dc.subjectWILD-TYPEen
dc.subjectImmunologyen
dc.titleRisks associated with the use of live-attenuated vaccine poliovirus strains and the strategies for control and eradication of paralytic poliomyelitisen
dc.typejournalArticleen


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