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dc.creatorPappas, I. S.en
dc.date.accessioned2015-11-23T10:44:51Z
dc.date.available2015-11-23T10:44:51Z
dc.date.issued2010
dc.identifier.issn10116583
dc.identifier.urihttp://hdl.handle.net/11615/32016
dc.description.abstractBreast cancer is the second cause of cancer mortality worldwide in humans and half of all tumours in dogs and there is an unmet need for novel anticancer agents. I have developed a new series of aryl ureido derivatives as anticancer agents. These compounds have a strong antiproliferative effect against canine breast cancer CMT-U27 cells at concentrations (1-10 μM) comparable to drugs that have already been used in chemotherapy such as gefitinib, soferanib and lapatinib. These results suggest that aryl ureido derivatives were potent inhibitors of proliferation of breast cancer cells. © PHARMAKON-Press.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-77954406791&partnerID=40&md5=069a50f433740116bd255ff9c51a317f
dc.subjectAryl ureido derivativesen
dc.subjectBreast canceren
dc.subjectCancer therapyen
dc.subjectCell growth inhibitorsen
dc.subjectamineen
dc.subjectbexaroteneen
dc.subjectgefitiniben
dc.subjectisoxazoleen
dc.subjectlapatiniben
dc.subjectpaclitaxelen
dc.subjectpurineen
dc.subjectpyrazineen
dc.subjectpyridazineen
dc.subjectpyridineen
dc.subjectpyrimidineen
dc.subjectsorafeniben
dc.subjectthiazoleen
dc.subjecturea derivativeen
dc.subjectanimal cellen
dc.subjectantineoplastic activityen
dc.subjectbreast carcinomaen
dc.subjectcancer cell cultureen
dc.subjectcancer chemotherapyen
dc.subjectCMT U27 cellen
dc.subjectconference paperen
dc.subjectcontrolled studyen
dc.subjectdrug synthesisen
dc.subjectnonhumanen
dc.titleDevelopment of a new series of aryl ureido derivatives as anticancer agents against breast cancer cellsen
dc.typejournalArticleen


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