Characterization of Metallo-beta-Lactamase VIM-27, an A57S Mutant of VIM-1 Associated with Klebsiella pneumoniae ST147

dc.creator	Papagiannitsis, C. C.	en
dc.creator	Kotsakis, S. D.	en
dc.creator	Petinaki, E.	en
dc.creator	Vatopoulos, A. C.	en
dc.creator	Tzelepi, E.	en
dc.creator	Miriagou, V.	en
dc.creator	Tzouvelekis, L. S.	en
dc.date.accessioned	2015-11-23T10:43:31Z
dc.date.available	2015-11-23T10:43:31Z
dc.date.issued	2011
dc.identifier	10.1128/aac.00238-11
dc.identifier.issn	0066-4804
dc.identifier.uri	http://hdl.handle.net/11615/31788
dc.description.abstract	VIM-27 metallo-beta-lactamase, an Ala(57) -> Ser variant of VIM-1, was identified in three Klebsiella pneumoniae isolates belonging to sequence type 147. bla(VIM-27) was part of a class 1 integron carried by non-self-transferable plasmids. Kinetic parameters and MIC determinations indicated that VIM-27 hydrolyzed most beta-lactams, especially imipenem and cefoxitin, less effectively than VIM-1.	en
dc.source	Antimicrobial Agents and Chemotherapy	en
dc.source.uri	<Go to ISI>://WOS:000291687900067
dc.subject	PSEUDOMONAS-AERUGINOSA	en
dc.subject	ESCHERICHIA-COLI	en
dc.subject	CLINICAL ISOLATE	en
dc.subject	VARIANT	en
dc.subject	GENE	en
dc.subject	Microbiology	en
dc.subject	Pharmacology & Pharmacy	en
dc.title	Characterization of Metallo-beta-Lactamase VIM-27, an A57S Mutant of VIM-1 Associated with Klebsiella pneumoniae ST147	en
dc.type	journalArticle	en

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