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Preparation of sirna-encapsulated plga nanoparticles for sustained release of sirna and evaluation of encapsulation efficiency

dc.creatorPantazis, P.en
dc.creatorDimas, K.en
dc.creatorWyche, J. H.en
dc.creatorAnant, S.en
dc.creatorHouchen, C. W.en
dc.creatorPanyam, J.en
dc.creatorRamanujam, R. P.en
dc.date.accessioned2015-11-23T10:42:24Z
dc.date.available2015-11-23T10:42:24Z
dc.date.issued2012
dc.identifier10.1007/978-1-61779-953-2_25
dc.identifier.isbn9781617799525
dc.identifier.issn10643745
dc.identifier.urihttp://hdl.handle.net/11615/31591
dc.description.abstractNanoparticles (NPs) formulated using poly (d,l-lactide-co-glycolide) (PLGA), a biodegradable, biocompatible, and clinically approved polymer, have been widely used for targeted drug delivery. Here we provide methods for preparing PLGA NPs that encapsulate small interfering RNA (siRNA). The siRNA NPs are formulated using a double-emulsion solvent evaporation technique with the addition of a small amount of the cationic polymer, polyethyleneimine, which significantly increases siRNA encapsulation. © 2012 Springer Science+Business Media, LLC.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84864841077&partnerID=40&md5=017479dfa7c27fd03b2bc27b6341a3b9
dc.subjectCancer therapyen
dc.subjectCancer treatmenten
dc.subjectDrug deliveryen
dc.subjectNanoparticlesen
dc.subjectPoly(lactic-co-glycolic) aciden
dc.subjectRNAien
dc.subjectsiRNAen
dc.subjectlactic aciden
dc.subjectnanoparticleen
dc.subjectpolyglycolic aciden
dc.subjectpolylactic acid polyglycolic acid copolymeren
dc.subjectpolylactic acid-polyglycolic acid copolymeren
dc.subjectsmall interfering RNAen
dc.subjectsolventen
dc.subjectarticleen
dc.subjectchemistryen
dc.subjectdrug delivery systemen
dc.subjectemulsionen
dc.subjectultrastructureen
dc.subjectDrug Delivery Systemsen
dc.subjectEmulsionsen
dc.subjectRNA, Small Interferingen
dc.subjectSolventsen
dc.titlePreparation of sirna-encapsulated plga nanoparticles for sustained release of sirna and evaluation of encapsulation efficiencyen
dc.typeotheren


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