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dc.creatorManta, S.en
dc.creatorKiritsis, C.en
dc.creatorDimopoulou, A.en
dc.creatorParmenopoulou, V.en
dc.creatorKollatos, N.en
dc.creatorTsotinis, A.en
dc.creatorKomiotis, D.en
dc.date.accessioned2015-11-23T10:38:47Z
dc.date.available2015-11-23T10:38:47Z
dc.date.issued2014
dc.identifier.issn22113525
dc.identifier.urihttp://hdl.handle.net/11615/30668
dc.description.abstractIn the search of effective, selective and nontoxic antiviral agents, a variety of nucleoside analogues have been synthesized, with different functionalities in the carbohydrate moiety and/or the heterocyclic base. Nucleoside analogues bearing double or triple bonds are recognized as an important class of biologically active compounds and appear to be prominent drugs in the management of several viral infections, including HSV, HIV, HBV, HCV and HCMV. Currently, unsaturated nucleoside mimetics, such as stavudine, abacavir and entecavir have been approved for the treatment of viral infections, while elvucitabine and β-L-2'-F-d4C are in clinical trials. The purpose of this review is to give an update of the recent developments on nucleosides and nucleoside analogues with unsaturation, in both cyclic and acyclic forms, which possess promising therapeutic potential, mainly antiviral. It covers analogues with ring sizes from three to six and provides useful data, aiming at enhancing chemical reactivity as a result of the sugar and base conformations. © 2014 Bentham Science Publishers.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84891766028&partnerID=40&md5=b99496fe57dcdd74b628c9d2f5d1acbb
dc.subjectAcyclicen
dc.subjectAntiviralen
dc.subjectBase modifieden
dc.subjectCarbocyclicen
dc.subjectExomethyleneen
dc.subjectTSAOen
dc.subjectUnsaturated nucleosidesen
dc.subject1',2' seco 4' C branched nucleosideen
dc.subject4 amino 2 butenyl acyclic nucleosideen
dc.subject4 amino 2 butenyl acyclic pyrimidine nucleosideen
dc.subject5 phosphopent 2 en yl nucleosidesen
dc.subject6 azauracil acyclonucleosideen
dc.subjectabacaviren
dc.subjectacyclic nucleosideen
dc.subjectarylethynyltriazole acyclonucleosideen
dc.subjectbitriazolyl acyclonucleosideen
dc.subjectcarbocyclic nucleosideen
dc.subjectcarbocyclic unsaturated nucleosideen
dc.subjectcyclobutyl nucleosideen
dc.subjectcyclopentyl nucleosideen
dc.subjectcyclopropyl nucleosideen
dc.subjectelvucitabineen
dc.subjectentecaviren
dc.subjectexocyclic methylene nucleosideen
dc.subjectnucleoside analogen
dc.subjectstavudineen
dc.subjectthio unsaturated nucleosideen
dc.subjectunclassified drugen
dc.subjectantiviral activityen
dc.subjectchemical structureen
dc.subjectclinical trial (topic)en
dc.subjectcytomegalovirus infectionen
dc.subjecthepatitis Ben
dc.subjecthepatitis Cen
dc.subjectherpes simplexen
dc.subjecthumanen
dc.subjectHuman immunodeficiency virus infectionen
dc.subjectmetabolismen
dc.subjectreviewen
dc.subjectstructure activity relationen
dc.subjectunsaturationen
dc.titleUnsaturation: An important structural feature to nucleosides' antiviral activityen
dc.typejournalArticleen


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