Todo DSpace

Mostrar el registro sencillo del ítem

Minimally invasive and selective hydrodynamic gene therapy of liver segments in the pig and human

dc.creatorKhorsandi, S. E.en
dc.creatorBachellier, P.en
dc.creatorWeber, J. C.en
dc.creatorGreget, M.en
dc.creatorJaeck, D.en
dc.creatorZacharoulis, D.en
dc.creatorRountas, C.en
dc.creatorHelmy, S.en
dc.creatorHelmy, A.en
dc.creatorAl-Waracky, M.en
dc.creatorSalama, H.en
dc.creatorJiao, L.en
dc.creatorNicholls, J.en
dc.creatorDavies, A. J.en
dc.creatorLevicar, N.en
dc.creatorJensen, S.en
dc.creatorHabib, N.en
dc.date.accessioned2015-11-23T10:34:47Z
dc.date.available2015-11-23T10:34:47Z
dc.date.issued2008
dc.identifier10.1038/sj.cgt.7701119
dc.identifier.issn9291903
dc.identifier.urihttp://hdl.handle.net/11615/29410
dc.description.abstractThis paper highlights our experience of the transfer of hydrodynamic gene therapy (HGT) from the large animal, the pig, into clinical practice. The modification of balloon catheters and the development of a minimally invasive technique to allow selective isolation of liver segments for HGT in the large animal and human are described. Finally, our preliminary results from a phase I clinical study of HGT for thrombopoietin (TPO) in cirrhotic patients with thrombocytopenia are discussed. Based on these provisional data, minimally invasive selective HGT of liver segments appears to be technically safe, but further work is required to optimize the efficiency of gene transfer in order to achieve clinical benefit. © 2008 Nature Publishing Group All rights reserved.en
dc.sourceCancer Gene Therapyen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-40549090572&partnerID=40&md5=f8d7623ce0ddd22981d8689a7b7ae5b0
dc.subjectHumanen
dc.subjectHydrodynamic gene therapyen
dc.subjectPigen
dc.subjectthrombopoietinen
dc.subjectabsence of side effectsen
dc.subjectadulten
dc.subjectageden
dc.subjectanimal experimenten
dc.subjectarticleen
dc.subjectballoon catheteren
dc.subjectclinical articleen
dc.subjectclinical practiceen
dc.subjectcontrolled studyen
dc.subjectdrug dose escalationen
dc.subjectdrug safetyen
dc.subjectdrug selectivityen
dc.subjectfemaleen
dc.subjectgene therapyen
dc.subjecthydrodynamics based transfectionen
dc.subjectliveren
dc.subjectliver cirrhosisen
dc.subjectmaleen
dc.subjectnonhumanen
dc.subjectpriority journalen
dc.subjectswineen
dc.subjectthrombocytopeniaen
dc.subjecttreatment outcomeen
dc.subjectAnimalsen
dc.subjectHumansen
dc.subjectMiddle Ageden
dc.subjectPlasmidsen
dc.subjectAnimaliaen
dc.subjectSuidaeen
dc.titleMinimally invasive and selective hydrodynamic gene therapy of liver segments in the pig and humanen
dc.typejournalArticleen


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem