Evolution of a rare vaccine-derived multirecombinant poliovirus
dc.creator | Karakasiliotis, I. | en |
dc.creator | Paximadi, E. | en |
dc.creator | Markoulatos, P. | en |
dc.date.accessioned | 2015-11-23T10:33:06Z | |
dc.date.available | 2015-11-23T10:33:06Z | |
dc.date.issued | 2005 | |
dc.identifier | 10.1099/vir.0.80823-0 | |
dc.identifier.issn | 0022-1317 | |
dc.identifier.uri | http://hdl.handle.net/11615/28989 | |
dc.description.abstract | Recombination is one of the mechanisms by which viral genomes evolve. A vaccine-derived multirecombinant poliovirus strain was isolated from a 5-month-old child with vaccine-associated paralytic poliomyelitis after oral poliovirus vaccine administration. The isolate had an S2/S1/S2/ S1 primary genomic structure as revealed by restriction fragment length polymorphism and sequencing analysis. Recombination of the middle S1/S2 region is extremely rare and one of the few characterized types of recombination with Sabin type 1 as a 5' partner. An attempt was made to perform evolutionary analysis of the contributing sequences using the identified mutations in comparison with the original Sabin sequences. A hypothesis is proposed for the order in which the identified recombination events occurred. | en |
dc.source.uri | <Go to ISI>://WOS:000232897400025 | |
dc.subject | CENTRAL-NERVOUS-SYSTEM | en |
dc.subject | IMMUNODEFICIENT PATIENT | en |
dc.subject | PARALYTIC | en |
dc.subject | POLIOMYELITIS | en |
dc.subject | WILD POLIOVIRUS | en |
dc.subject | RECOMBINANT | en |
dc.subject | STRAINS | en |
dc.subject | RNA | en |
dc.subject | CIRCULATION | en |
dc.subject | HISPANIOLA | en |
dc.subject | MUTATIONS | en |
dc.subject | Biotechnology & Applied Microbiology | en |
dc.subject | Virology | en |
dc.title | Evolution of a rare vaccine-derived multirecombinant poliovirus | en |
dc.type | journalArticle | en |
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