dc.creator | Iliadis, C. | en |
dc.creator | Apostolopoulos, D. J. | en |
dc.creator | Papadopoulos, G. | en |
dc.creator | Tzortzidis, F. | en |
dc.creator | Wozniak, G. | en |
dc.creator | Georgoulias, P. | en |
dc.creator | Kunz, A. | en |
dc.creator | Panagiotopoulos, V. | en |
dc.creator | Maraziotis, T. | en |
dc.creator | Vassilakos, P. J. | en |
dc.date.accessioned | 2015-11-23T10:30:21Z | |
dc.date.available | 2015-11-23T10:30:21Z | |
dc.date.issued | 2006 | |
dc.identifier.issn | 14270994 | |
dc.identifier.uri | http://hdl.handle.net/11615/28570 | |
dc.description.abstract | Aim: To estimate the association between single photon emission computed tomography (SPECT) imaging and neuro-specific enolase (NSE) serum level measurement in patients with subarachnoid haemorrhage (SAH) and also to present our experience in using these data for patient evaluation. Material and method: Thirty-five patients (18 female and 17 male, mean age 57.5 ± 11.9 y) with clinical findings of vasospasm after SAH underwent 99mTC-ECD SPECT imaging. In 23 out of the 35 patients, serum levels of NSE were assessed on admission. Brain perfusion was measured semi-quantitatively using symmetrical regions of interest, automatically drawn over cortical and subcortical structures on consecutive transverse slices. A summed perfusion defect score (SPDS) was used to' quantify the brain perfusion. Statistical analysis was carried out using the Kruskal-Wallis test, Mann-Whitney U test and ROC analysis, as appropriate. Results: Eighteen patients had abnormal SPECT studies. The patients were divided into three groups according to NSE levels. Group I comprised 13 patients with NSE values ≤ 15 ng/ml, group II comprised 7 patients with 15 ng/ml <NSE < 19 ng/ml, and group III comprised 3 patients with NSE ≥ 19 ng/ml. SPECT/SPDS data and NSE levels of groups II and I were positively linearly correlated (Spearman's coeff = 0.71, p<0.05), while group III clearly defines a separate population. The linear correlation between SPECT/SPDS and NSE was statistically significant (p<0.05). Very high NSE values were noticed in three patients who eventually died. Conclusion: Both SPECT abnormalities and high serum NSE concentration are potentially helpful in the evaluation of patients with SAH. ©Borgis. | en |
dc.source.uri | http://www.scopus.com/inward/record.url?eid=2-s2.0-55049140240&partnerID=40&md5=b0bb8026fc79475570c05725dc94a355 | |
dc.subject | 99mTc-ECD SPECT | en |
dc.subject | Cerebral blood flow (CBF) | en |
dc.subject | Neuro-specific enolase (NSE) | en |
dc.subject | Subarachnoid haemorrhage (SAH) | en |
dc.subject | cysteine ethyl ester tc 99m | en |
dc.subject | neuron specific enolase | en |
dc.subject | adolescent | en |
dc.subject | adult | en |
dc.subject | aged | en |
dc.subject | article | en |
dc.subject | brain perfusion | en |
dc.subject | brain vasospasm | en |
dc.subject | clinical article | en |
dc.subject | female | en |
dc.subject | Glasgow coma scale | en |
dc.subject | Glasgow outcome scale | en |
dc.subject | human | en |
dc.subject | male | en |
dc.subject | patient assessment | en |
dc.subject | prognosis | en |
dc.subject | quantitative analysis | en |
dc.subject | sensitivity and specificity | en |
dc.subject | single photon emission computer tomography | en |
dc.subject | subarachnoid hemorrhage | en |
dc.title | Brain perfusion SPECT with 99mTC-ECD and serum neuron-specific enolase in patients with spontaneous subarachnoid haemorrhage and clinical vasospasm | en |
dc.type | journalArticle | en |