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dc.creatorHadjigeorgiou, G. H.en
dc.creatorXiromerisiou, G.en
dc.creatorGourbali, V.en
dc.creatorAggelakis, K.en
dc.creatorScarmeas, N.en
dc.creatorPapadimitriou, A.en
dc.creatorSingleton, A.en
dc.date.accessioned2015-11-23T10:29:22Z
dc.date.available2015-11-23T10:29:22Z
dc.date.issued2006
dc.identifier10.1002/mds.20752
dc.identifier.issn8853185
dc.identifier.urihttp://hdl.handle.net/11615/28283
dc.description.abstractThe α-synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD; adjusted odd ratio = 3.25; 95% CI = 1.80-5.87). Survival analyses (Cox proportional hazards models) were employed to explore the influence of genotypes on age at onset of PD. Age at onset of carriers of at least one Rep1 allele 2 was earlier (3.6 years) compared to noncarriers (adjusted hazard ratio = 2.21; 95% CI = 1.58-3.10). Kaplan-Meier analysis also supported a dosage effect of Rep1 allele 2 on age at onset. For Rep1 allele 1, there was neither association with risk of PD nor influence on age at onset. This is the first study showing an influence of Rep1 polymorphism on age at onset of PD. © 2005 Movement Disorder Society.en
dc.sourceMovement Disordersen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-33646249380&partnerID=40&md5=a0edd80743ee235bd0e1f528cdd137d1
dc.subjectα-synucleinen
dc.subjectAssociation studyen
dc.subjectParkinson's diseaseen
dc.subjectRep1, polymorphismen
dc.subjectalpha synucleinen
dc.subjectprotein Rep 1en
dc.subjectunclassified drugen
dc.subjectadulten
dc.subjectageden
dc.subjectanalysis of varianceen
dc.subjectarticleen
dc.subjectconfidence intervalen
dc.subjectcontrolled studyen
dc.subjectdisease associationen
dc.subjectdisease carrieren
dc.subjectethnologyen
dc.subjectfemaleen
dc.subjectgene frequencyen
dc.subjectgenetic polymorphismen
dc.subjectgenome analysisen
dc.subjectgenotypeen
dc.subjectGreeceen
dc.subjecthigh risk populationen
dc.subjecthumanen
dc.subjectKaplan Meier methoden
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectnucleotide sequenceen
dc.subjectonset ageen
dc.subjectParkinson diseaseen
dc.subjectpopulation researchen
dc.subjectpriority journalen
dc.subjectpromoter regionen
dc.subjectprotein functionen
dc.subjectrisk assessmenten
dc.subjectsurvival rateen
dc.subjectAge of Onseten
dc.subjectAged, 80 and overen
dc.subjectalpha-Synucleinen
dc.subjectCase-Control Studiesen
dc.subjectChi-Square Distributionen
dc.subjectConfidence Intervalsen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectHumansen
dc.subjectMicrosatellite Repeatsen
dc.subjectMiddle Ageden
dc.subjectOdds Ratioen
dc.subjectPolymorphism, Geneticen
dc.subjectPromoter Regions (Genetics)en
dc.subjectSurvival Analysisen
dc.titleAssociation of α-synuclein Rep1 polymorphism and Parkinson's disease: Influence of Rep1 on age at onseten
dc.typejournalArticleen


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