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Polyphenolic composition of grape stem extracts affects antioxidant activity in endothelial and muscle cells

dc.creatorGoutzourelas, N.en
dc.creatorStagos, D.en
dc.creatorSpanidis, Y.en
dc.creatorLiosi, M.en
dc.creatorApostolou, A.en
dc.creatorPriftis, A.en
dc.creatorHaroutounian, S.en
dc.creatorSpandidos, D. A.en
dc.creatorTsatsakis, A. M.en
dc.creatorKouretas, D.en
dc.date.accessioned2015-11-23T10:29:04Z
dc.date.available2015-11-23T10:29:04Z
dc.date.issued2015
dc.identifier10.3892/mmr.2015.4216
dc.identifier.issn17912997
dc.identifier.urihttp://hdl.handle.net/11615/28161
dc.description.abstractThe aim of the present study was the assessment of the antioxidant effects of polyphenolic extracts derived from the stems of three Greek grape varieties (Moshomayro, Mavrotragano and Mandilaria) in endothelial (EA.hy926) and muscle (C2C12) cells. We also investigated the effects of the polyphenolic composition on the antioxidant effects of the grape stem extracts. For this purpose, the endothelial and muscle cells were treated with low non-cytotoxic concentrations of the extracts for 24 h in order to assess the effects of the extracts on cellular redox status using oxidative stress biomarkers. The oxidative stress markers were thiobarbituric acid reactive substances (TBARS), protein carbonyl (CARB) levels, reactive oxygen species (ROS) levels and glutathione (GSH) levels. The results revealed that treatment of the EA.hy926 cells with.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84940511951&partnerID=40&md5=e99b243438ce8a00500313961b36309a
dc.subjectAntioxidanten
dc.subjectEndothelial cellsen
dc.subjectFlow cytometryen
dc.subjectGrape stem extractsen
dc.subjectMuscle Cellsen
dc.subjectOxidative stressen
dc.subjectPolyphenolsen
dc.subjectcaffeic aciden
dc.subjectcarbonyl derivativeen
dc.subjectcatechinen
dc.subjectcoumaric aciden
dc.subjectepicatechinen
dc.subjectferulic aciden
dc.subjectflavanol derivativeen
dc.subjectgallic aciden
dc.subjectglutathioneen
dc.subjectgrape seed extracten
dc.subjectkaempferolen
dc.subjectMandilaria extracten
dc.subjectMavrotragano extracten
dc.subjectMoshomavro extracten
dc.subjectpolyphenol derivativeen
dc.subjectquercetinen
dc.subjectreactive oxygen metaboliteen
dc.subjectresveratrolen
dc.subjectrutosideen
dc.subjectstilbene derivativeen
dc.subjectsyringic aciden
dc.subjectthiobarbituric acid reactive substanceen
dc.subjecttrans resveratrolen
dc.subjectunclassified drugen
dc.subjectVitis vinifera extracten
dc.subjectantioxidant activityen
dc.subjectArticleen
dc.subjectcell viabilityen
dc.subjectchemical compositionen
dc.subjectcomparative studyen
dc.subjectconcentration responseen
dc.subjectcontrolled studyen
dc.subjectcytotoxic concentrationen
dc.subjectDPPH radical scavenging assayen
dc.subjectdrug effecten
dc.subjectendothelium cellen
dc.subjectgrapeen
dc.subjecthigh performance liquid chromatographyen
dc.subjecthumanen
dc.subjecthuman cellen
dc.subjectlipid peroxidationen
dc.subjectmuscle cellen
dc.subjectplant stemen
dc.subjectprotein carbonylationen
dc.subjectredox stressen
dc.subjectumbilical vein endothelial cellen
dc.subjectvascular smooth muscle cellen
dc.titlePolyphenolic composition of grape stem extracts affects antioxidant activity in endothelial and muscle cellsen
dc.typejournalArticleen


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