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dc.creatorFlouris, A. D.en
dc.creatorKoutedakis, Y.en
dc.date.accessioned2015-11-23T10:26:36Z
dc.date.available2015-11-23T10:26:36Z
dc.date.issued2011
dc.identifier10.1097/MCP.0b013e328343165d
dc.identifier.issn1070-5287
dc.identifier.urihttp://hdl.handle.net/11615/27489
dc.description.abstractPurpose of review This review critically evaluates the existing biological evidence regarding the immediate and short-term respiratory consequences of secondhand smoke (SHS). Recent findings A 1-h exposure to SHS at bar/restaurant levels generates a marked inflammatory reaction and significant decrements on lung function. These deleterious effects of SHS are exacerbated when physical activity follows the SHS exposure, particularly in less fit individuals. The main respiratory effect mechanisms of SHS include a direct induction of growth factors resulting in airway remodelling and alterations in nitric oxide regulation. Pharmacological agents that increase either apical membrane chloride conductance or basolateral membrane potassium conductance may be of therapeutic benefit in patients with diseases related to SHS exposure. Moreover, treatment with statins has shown beneficial effects towards preventing the SHS-induced pulmonary hypertension, vascular remodelling, and endothelial dysfunction. Summary Based on recently discovered evidence, even brief and short-term exposures to SHS generate significant adverse effects on the human respiratory system. Future research directions in this area include the concentrations of tobacco smoke constituents in the alveolar milieu following SHS exposure, individual susceptibility to SHS, as well as pharmacological treatments for reversing the SHS-induced airway remodelling.en
dc.source.uri<Go to ISI>://WOS:000286881200010
dc.subjectairway remodellingen
dc.subjectenvironmental tobacco smokeen
dc.subjectinflammationen
dc.subjectpassiveen
dc.subjectsmokingen
dc.subjectrespiratory diseaseen
dc.subjectOBSTRUCTIVE PULMONARY-DISEASEen
dc.subjectEXHALED NITRIC-OXIDEen
dc.subjectC-REACTIVE PROTEINen
dc.subjectENVIRONMENTAL TOBACCO-SMOKEen
dc.subjectTHYROID-HORMONE SECRETIONen
dc.subjectLOW-DENSITY-LIPOPROTEINen
dc.subjectLUNG-FUNCTIONen
dc.subjectPASSIVE SMOKINGen
dc.subjectCIGARETTE-SMOKINGen
dc.subjectINTERFERON-GAMMAen
dc.subjectRespiratory Systemen
dc.titleImmediate and short-term consequences of secondhand smoke exposure on the respiratory systemen
dc.typejournalArticleen


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