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Serum osteoprotegerin is markedly increased and may contribute to decreased blood T cell count in hemodialysis patients
dc.creator | Eleftheriadis, T. | en |
dc.creator | Yiannaki, E. | en |
dc.creator | Liakopoulos, V. | en |
dc.creator | Antoniadi, G. | en |
dc.creator | Pissas, G. | en |
dc.creator | Galaktidou, G. | en |
dc.creator | Stefanidis, I. | en |
dc.date.accessioned | 2015-11-23T10:26:14Z | |
dc.date.available | 2015-11-23T10:26:14Z | |
dc.date.issued | 2013 | |
dc.identifier | 10.1007/s11255-012-0371-1 | |
dc.identifier.issn | 0301-1623 | |
dc.identifier.uri | http://hdl.handle.net/11615/27348 | |
dc.description.abstract | Acquired immunity is impaired in hemodialysis (HD) patients, and decreased T cell number may contribute. Receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) are expressed in cells of the immune system and affect T cell development, homeostasis and proliferation. Serum levels of RANKL and OPG and their relation to blood T cell number were evaluated in HD patients. Thirty-four HD patients and 20 healthy controls participated in the study. Serum RANKL and OPG were measured by ELISA and T cell number was assessed by flow cytometry. Median RANKL concentration did not differ between HD patients and healthy volunteers (300.00 pmol/L; range, 3,340.00 vs. 330.00 pmol/L; range, 440.00 pmol/L; p = 0.528). Median OPG was markedly higher in HD patients than in healthy volunteers (13.12 +/- A 4.71 vs. 4.71 +/- A 0.93 pmol/L, p < 0.001). The T cell count was significantly lower in HD patients than in healthy controls (1,177.00 +/- A 567.71 vs. 1,519.80 +/- A 594.96 cells/mm(3), p = 0.044). In HD patients, blood T cell number was correlated positively with serum RANKL (rho = 0.462, p = 0.007) and negatively to serum OPG (r = -0.449, p = 0.008). Serum OPG concentration is markedly increased in HD patients and may contribute to decreased blood T cell count and impaired acquired immunity that characterizes this population. | en |
dc.source | International Urology and Nephrology | en |
dc.source.uri | <Go to ISI>://WOS:000327950000018 | |
dc.subject | Hemodialysis | en |
dc.subject | RANKL | en |
dc.subject | Osteoprotegerin | en |
dc.subject | T cell | en |
dc.subject | KAPPA-B LIGAND | en |
dc.subject | CHRONIC-RENAL-FAILURE | en |
dc.subject | TNF FAMILY-MEMBER | en |
dc.subject | DENDRITIC | en |
dc.subject | CELLS | en |
dc.subject | RECEPTOR ACTIVATOR | en |
dc.subject | CYTOKINE PRODUCTION | en |
dc.subject | EPITHELIAL-CELLS | en |
dc.subject | TRANCE | en |
dc.subject | PROLIFERATION | en |
dc.subject | INFLAMMATION | en |
dc.subject | Urology & Nephrology | en |
dc.title | Serum osteoprotegerin is markedly increased and may contribute to decreased blood T cell count in hemodialysis patients | en |
dc.type | journalArticle | en |
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