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Endothelin-3 and PRL levels in the maternal and fetal circulation at delivery
dc.creator | Dafopoulos, K. | en |
dc.creator | Boli, A. | en |
dc.creator | Kallitsaris, A. | en |
dc.creator | Malamitsi-Puchner, A. | en |
dc.creator | Kollios, G. | en |
dc.creator | Messinis, I. E. | en |
dc.date.accessioned | 2015-11-23T10:24:55Z | |
dc.date.available | 2015-11-23T10:24:55Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 0391-4097 | |
dc.identifier.uri | http://hdl.handle.net/11615/26785 | |
dc.description.abstract | Objective: The aim of the present cross-sectional study was to test the hypothesis that endothelin-3 (ET-3) is involved in PRL secretion via systemic hormonal interaction during labor. Materials and methods: Fifty healthy pregnant women with singleton pregnancies were included in the present study. At delivery, blood samples were drawn from umbilical vein and artery. At the same time, a blood sample was obtained from a peripheral vein of the mother. In all blood samples, plasma ET-3 and serum PRL concentrations were determined. The main outcome measures were the differences between maternal peripheral blood, umbilical artery and vein in terms of ET-3 and PRL levels, and the associations between ET-3 and PRL levels. Results: ET-3 values (mean +/- SEM) in umbilical artery did not differ significantly from those in umbilical vein (4.94 +/- 0.27 vs 5.05 +/- 0.32 pg/ml) but were in both vessels significantly higher than in maternal vein (1.14 +/- 0.56 pg/ml, p < 0.001). Serum PRL values showed similar patterns. There was a significant positive correlation of the ET-3 levels between umbilical artery and vein (r=0.906, p < 0.001), but not between maternal peripheral venous blood and the umbilical vessels. Similar correlations were found for PRL values. However, no significant correlations were found between ET-3 and PRL levels in all vessels studied. Conclusions: The present study demonstrates for the first time that ET-3 levels are higher in fetal than in maternal circulation at term. The lack of correlation between ET-3 and PRL levels suggests that ET-3 does not play an important endocrine role in the control of maternal and fetal PRL secretion during labor. | en |
dc.source.uri | <Go to ISI>://WOS:000244914100010 | |
dc.subject | endothelin-3 | en |
dc.subject | PRL | en |
dc.subject | umbilical vessels | en |
dc.subject | delivery | en |
dc.subject | PROLACTIN SECRETION | en |
dc.subject | ANTERIOR-PITUITARY | en |
dc.subject | CELLS | en |
dc.subject | RECEPTORS | en |
dc.subject | LOCALIZATION | en |
dc.subject | EXPRESSION | en |
dc.subject | PREGNANCY | en |
dc.subject | RELEASE | en |
dc.subject | PEPTIDE | en |
dc.subject | WOMEN | en |
dc.subject | Endocrinology & Metabolism | en |
dc.title | Endothelin-3 and PRL levels in the maternal and fetal circulation at delivery | en |
dc.type | journalArticle | en |
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