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Alpha-synuclein repeat variants and survival in parkinson's disease

dc.creatorChung, S. J.en
dc.creatorBiernacka, J. M.en
dc.creatorArmasu, S. M.en
dc.creatorAnderson, K.en
dc.creatorFrigerio, R.en
dc.creatorAasly, J. O.en
dc.creatorAnnesi, G.en
dc.creatorBentivoglio, A. R.en
dc.creatorBrighina, L.en
dc.creatorChartier-Harlin, M. C.en
dc.creatorGoldwurm, S.en
dc.creatorHadjigeorgiou, G.en
dc.creatorJasinska-Myga, B.en
dc.creatorJeon, B. S.en
dc.creatorKim, Y. J.en
dc.creatorKrüger, R.en
dc.creatorLesage, S.en
dc.creatorMarkopoulou, K.en
dc.creatorMellick, G.en
dc.creatorMorrison, K. E.en
dc.creatorPuschmann, A.en
dc.creatorTan, E. K.en
dc.creatorCrosiers, D.en
dc.creatorTheuns, J.en
dc.creatorVan Broeckhoven, C.en
dc.creatorWirdefeldt, K.en
dc.creatorWszolek, Z. K.en
dc.creatorElbaz, A.en
dc.creatorMaraganore, D. M.en
dc.creatorYahalom, G.en
dc.creatorOrlev, Y.en
dc.creatorCohen, O. S.en
dc.creatorKozlova, E.en
dc.creatorFriedman, E.en
dc.creatorInzelberg, R.en
dc.creatorHassin-Baer, S.en
dc.date.accessioned2015-11-23T10:24:48Z
dc.date.available2015-11-23T10:24:48Z
dc.date.issued2014
dc.identifier10.1002/mds.25841
dc.identifier.issn8853185
dc.identifier.urihttp://hdl.handle.net/11615/26727
dc.description.abstractObjectives: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value=0.01). Conclusions: In our large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed. © 2014 International Parkinson and Movement Disorder Society.en
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84904431856&partnerID=40&md5=30a48d7e05bddf3db94f2e62c7c16665
dc.subjectAssociationen
dc.subjectGeneen
dc.subjectParkinson's diseaseen
dc.subjectSurvivalen
dc.subjectα-synucleinen
dc.subjectalpha synucleinen
dc.subjectadulten
dc.subjectageden
dc.subjectclinical trialen
dc.subjectdinucleotide repeaten
dc.subjectfemaleen
dc.subjectgene frequencyen
dc.subjectgenetic associationen
dc.subjectgenetic predispositionen
dc.subjectgeneticsen
dc.subjectgenotypeen
dc.subjecthumanen
dc.subjectinternational cooperationen
dc.subjectmaleen
dc.subjectmiddle ageden
dc.subjectmortalityen
dc.subjectmulticenter studyen
dc.subjectonset ageen
dc.subjectParkinson diseaseen
dc.subjectvery elderlyen
dc.subjectAge of Onseten
dc.subjectAged, 80 and overen
dc.subjectalpha-Synucleinen
dc.subjectDinucleotide Repeatsen
dc.subjectGenetic Association Studiesen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectHumansen
dc.titleAlpha-synuclein repeat variants and survival in parkinson's diseaseen
dc.typejournalArticleen


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