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The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle

dc.creatorBori, Z.en
dc.creatorZhao, Z.en
dc.creatorKoltai, E.en
dc.creatorFatouros, I. G.en
dc.creatorJamurtas, A. Z.en
dc.creatorDouroudos, I. I.en
dc.creatorTerzis, G.en
dc.creatorChatzinikolaou, A.en
dc.creatorSovatzidis, A.en
dc.creatorDraganidis, D.en
dc.creatorBoldogh, I.en
dc.creatorRadak, Z.en
dc.date.accessioned2015-11-23T10:24:00Z
dc.date.available2015-11-23T10:24:00Z
dc.date.issued2012
dc.identifier10.1016/j.exger.2012.03.004
dc.identifier.issn5315565
dc.identifier.urihttp://hdl.handle.net/11615/26364
dc.description.abstractAging results in a significant decline in aerobic capacity and impaired mitochondrial function. We have tested the effects of moderate physical activity on aerobic capacity and a single bout of exercise on the expression profile of mitochondrial biogenesis, and fusion and fission related genes in skeletal muscle of human subjects. Physical activity attenuated the aging-associated decline in VO2 max (p<0.05). Aging increased and a single exercise bout decreased the expression of nuclear respiratory factor-1 (NRF1), while the transcription factor A (TFAM) expression showed a strong relationship with VO 2max and increased significantly in the young physically active group. Mitochondrial fission representing FIS1 was induced by regular physical activity, while a bout of exercise decreased fusion-associated gene expression. The expression of polynucleotide phosphorylase (PNPase) changed inversely in young and old groups and decreased with aging. The A2 subunit of cyclic AMP-activated protein kinase (AMPK) was induced by a single bout of exercise in skeletal muscle samples of both young and old subjects (p<0.05). Our data suggest that moderate levels of regular physical activity increases a larger number of mitochondrial biogenesis-related gene expressions in young individuals than in aged subjects. Mitochondrial fission is impaired by aging and could be one of the most sensitive markers of the age-associated decline in the adaptive response to physical activity. © 2012 Elsevier Inc.en
dc.sourceExperimental Gerontologyen
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-84861183528&partnerID=40&md5=2e91cb8084703ebf36ccba9a8b93f045
dc.subjectAgingen
dc.subjectExerciseen
dc.subjectFusion and fissionen
dc.subjectMitochondrial biogenesisen
dc.subjectSkeletal muscleen
dc.subjectantiinflammatory agenten
dc.subjectcell nucleus DNAen
dc.subjectcyclic AMP dependent protein kinaseen
dc.subjectcytochrome c oxidaseen
dc.subjectmessenger RNAen
dc.subjectmitochondrial DNAen
dc.subjectmitochondrial proteinen
dc.subjectnebivololen
dc.subjectnuclear respiratory factor 1en
dc.subjectpolyribonucleotide nucleotidyltransferaseen
dc.subjectprobucolen
dc.subjecttranscription factoren
dc.subjectadulten
dc.subjectaerobic capacityen
dc.subjectarticleen
dc.subjectbiogenesisen
dc.subjectcontrolled studyen
dc.subjectfusion geneen
dc.subjectgene expressionen
dc.subjecthumanen
dc.subjecthuman experimenten
dc.subjectmaleen
dc.subjectnormal humanen
dc.subjectphysical activityen
dc.subjectpriority journalen
dc.subjectprotein expressionen
dc.subjectsittingen
dc.subjecttrainingen
dc.subjecttreadmill exerciseen
dc.subjectAgeden
dc.subjectGene Expression Regulationen
dc.subjectHumansen
dc.subjectMiddle Ageden
dc.subjectMitochondria, Muscleen
dc.subjectMitochondrial Proteinsen
dc.subjectMuscle Proteinsen
dc.subjectMuscle, Skeletalen
dc.subjectOxygen Consumptionen
dc.subjectReal-Time Polymerase Chain Reactionen
dc.subjectRNA, Messengeren
dc.subjectYoung Adulten
dc.titleThe effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscleen
dc.typejournalArticleen


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