Report of two novel chromosomal translocations in chronic lymphocytic leukemia

dc.creator	Athanasiadou, A.	en
dc.creator	Stamatopoulos, K.	en
dc.creator	Tsompanakou, A.	en
dc.creator	Foutsitsakis, D.	en
dc.creator	Fassas, A.	en
dc.creator	Anagnostopoulos, A.	en
dc.creator	Tsezou, A.	en
dc.date.accessioned	2015-11-23T10:23:11Z
dc.date.available	2015-11-23T10:23:11Z
dc.date.issued	2005
dc.identifier	10.1080/10428190400011591
dc.identifier.issn	1042-8194
dc.identifier.uri	http://hdl.handle.net/11615/25978
dc.description.abstract	Two novel chromosomal translocations were identified in 2 patients with chronic lymphocytic leukemia (CLL). Case 1: 60 year-old male, stage Rai 0/Binet A, with mutated immunoglobulin heavy (IgH) and lambda (Iglambda) light chain genes; karyotype: 46, XY, t(9;12)(q12;p11) [3]/ 46, XY [22]. Case 2: 56 year-old male, stage Rai 2/Binet B, with mutated IgH and unmutated Iglambda genes; karyotype: 46, XY, add(10)(q26), t(13;18)(q14;q21) [8]/ 46, XY [27]. Although both translocations are novel, the involved breakpoints (especially 13q14 and 18q21) have been reported to participate in various aberrations in CLL patients. Aberrations affecting bands 9q12 and 12p11, as in case 1, are generally rare.	en
dc.source	Leukemia & Lymphoma	en
dc.source.uri	<Go to ISI>://WOS:000225877700017
dc.subject	GENOMIC ABERRATIONS	en
dc.subject	GENES	en
dc.subject	Oncology	en
dc.subject	Hematology	en
dc.title	Report of two novel chromosomal translocations in chronic lymphocytic leukemia	en
dc.type	journalArticle	en

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