dc.creator | Athanasiadou, A. | en |
dc.creator | Stamatopoulos, K. | en |
dc.creator | Tsezou, A. | en |
dc.creator | Vadikolia, C. | en |
dc.creator | Asteriou, O. | en |
dc.creator | Fassas, A. | en |
dc.creator | Anagnostopoulos, A. | en |
dc.date.accessioned | 2015-11-23T10:23:11Z | |
dc.date.available | 2015-11-23T10:23:11Z | |
dc.date.issued | 2006 | |
dc.identifier | 10.1080/10428190600881447 | |
dc.identifier.issn | 1042-8194 | |
dc.identifier.uri | http://hdl.handle.net/11615/25977 | |
dc.description.abstract | One-hundred-and-thirty typical, unselected CLL cases were studied by conventional cytogenetic analysis. Seventy-three patients (56.2%) had normal karyotype ('normal sub-group'), while 57/130 patients (43.8%) had abnormal karyotype. Twenty-two of 57 patients (38.6%) carried more than one abnormality. Six novel chromosomal abnormalities were detected in five patients: (i) t(3; 13)(q14; q34); (ii) t(Y; 11)(q12; q23), del( 13)(q12q14); (iii) dic(3; 11)(p21; q23); (iv) t( 3; 5)(q29; q23); ( v) t( 3; 22) ( p21; q13); and ( vi) t( 1; 13)(p12; q12). Three of five patients carrying novel translocations had progressive disease. The true biological and clinical significance of novel chromosomal abnormalities remains to be determined. | en |
dc.source | Leukemia & Lymphoma | en |
dc.source.uri | <Go to ISI>://WOS:000241581800017 | |
dc.subject | CLL | en |
dc.subject | translocation | en |
dc.subject | FISH | en |
dc.subject | immunoglobulin genes | en |
dc.subject | GENOMIC ABERRATIONS | en |
dc.subject | TRANSLOCATIONS | en |
dc.subject | Oncology | en |
dc.subject | Hematology | en |
dc.title | Report of novel chromosomal abnormalities in a series of 130 chronic lymphocytic leukemia patients studied by classic cytogenetic analysis | en |
dc.type | journalArticle | en |