• Atrial high-rate episode duration thresholds and thromboembolic risk: A systematic review and meta-analysis 

      Sagris D., Georgiopoulos G., Pateras K., Perlepe K., Korompoki E., Milionis H., Tsiachris D., Chan C., Lip G.Y.H., Ntaios G. (2021)
      BACKGROUND: Available evidence supports an association between atrial high-rate episode (AHRE) burden and thromboembolic risk, but the necessary extent and duration of AHREs to increase the thromboembolic risk remain to ...
    • Data-driven machine-learning analysis of potential embolic sources in embolic stroke of undetermined source 

      Ntaios G., Weng S.F., Perlepe K., Akyea R., Condon L., Lambrou D., Sirimarco G., Strambo D., Eskandari A., Karagkiozi E., Vemmou A., Korompoki E., Manios E., Makaritsis K., Vemmos K., Michel P. (2021)
      Background and purpose: Hierarchical clustering, a common ‘unsupervised’ machine-learning algorithm, is advantageous for exploring potential underlying aetiology in particularly heterogeneous diseases. We investigated ...
    • Early versus Late initiation of direct oral Anticoagulants in post-ischaemic stroke patients with atrial fibrillatioN (ELAN): Protocol for an international, multicentre, randomised-controlled, two-arm, open, assessor-blinded trial 

      Fischer U., Trelle S., Branca M., Salanti G., Paciaroni M., Ferrari C., Abend S., Beyeler S., Strbian D., Thomalla G., Ntaios G., Bonati L.H., Michel P., Nedeltchev K., Gattringer T., Sandset E.C., Kelly P., Lemmens R., Koga M., Sylaja P.N., de Sousa D.A., Bornstein N.M., Gdovinova Z., Seiffge D.J., Gralla J., Horvath T., Dawson J. (2022)
      Rationale: Direct oral anticoagulants (DOAC) are highly effective in preventing ischaemic strokes in people with atrial fibrillation (AF). However, it is unclear how soon they should be started after acute ischaemic stroke ...
    • Embolic Stroke of Undetermined Source: JACC Review Topic of the Week 

      Ntaios G. (2020)
      The term embolic stroke of undetermined source (ESUS) was introduced in 2014 to describe patients with a nonlacunar ischemic stroke and no convincing etiology. The terms ESUS and cryptogenic stroke are not synonyms, as the ...
    • Embolic Strokes of Undetermined Source in the Athens Stroke Registry A Descriptive Analysis 

      Ntaios, G.; Papavasileiou, V.; Milionis, H.; Makaritsis, K.; Manios, E.; Spengos, K.; Michel, P.; Vemmos, K. (2015)
      Background and Purpose-A new clinical construct termed embolic stroke of undetermined source (ESUS) was recently introduced, but no such population has been described yet. Our aim is to provide a detailed descriptive ...
    • Interrupted versus uninterrupted anticoagulation therapy for catheter ablation in adults with arrhythmias 

      Bawazeer G.A., Alkofide H., Alsharafi A., Babakr N., Altorkistani A., Kashour T., Miligkos M., AlFaleh K., Al-Ansary L.A. (2019)
      This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:. The objective of this review is to systematically compare the efficacy and harms of interrupted versus uninterrupted anticoagulation ...
    • A Mechanistic and pathophysiological approach for stroke associated with drugs of abuse 

      Tsatsakis A., Docea A.O., Calina D., Tsarouhas K., Zamfira L.-M., Mitrut R., Sharifi-Rad J., Kovatsi L., Siokas V., Dardiotis E., Drakoulis N., Lazopoulos G., Tsitsimpikou C., Mitsias P., Neagu M. (2019)
      Drugs of abuse are associated with stroke, especially in young individuals. The major classes of drugs linked to stroke are cocaine, amphetamines, heroin, morphine, cannabis, and new synthetic cannabinoids, along with ...
    • A meta-analysis evaluating the role of high-intensity focused ultrasound (HIFU) as a fourth treatment modality for patients with locally advanced pancreatic cancer 

      Fergadi M.P., Magouliotis D.E., Rountas C., Vlychou M., Athanasiou T., Symeonidis D., Pappa P.A., Zacharoulis D. (2022)
      Background: This study aimed to evaluate the outcomes of high-intensity focused ultrasound (HIFU) on patients with advanced pancreatic cancer. Methods: A literature search was performed in PubMed, Scopus and Cochrane ...
    • Microbleeds and the Effect of Anticoagulation in Patients with Embolic Stroke of Undetermined Source: An Exploratory Analysis of the NAVIGATE ESUS Randomized Clinical Trial 

      Shoamanesh A., Hart R.G., Connolly S.J., Kasner S.E., Smith E.E., Martí-Fàbregas J., Liu Y.Y., Uchiyama S., Mikulik R., Veltkamp R., O'Donnell M.J., Ntaios G., Muir K.W., Field T.S., Santo G.C., Olavarria V., Mundl H., Lutsep H., Berkowitz S.D., Sharma M. (2021)
      Importance: The reported associations of cerebral microbleeds with recurrent stroke and intracerebral hemorrhage have raised concerns regarding antithrombotic treatment in patients with a history of stroke and microbleeds ...
    • Predicting Short-term Mortality in Patients With Pulmonary Embolism: A Simple Model 

      Papaioannou, A. I.; Kastanis, A.; Malli, F.; Zakynthinos, E.; Minas, M.; Mpakarozi, M.; Moka, S.; Zintzaras, E.; Gourgoulianis, K. I.; Daniil, Z. (2013)
      Background: The aim of the present study was to develop a simple prognostic rule that could classify patients with pulmonary embolism (PE) into categories of increased risk of 30-day mortality. Methods: One hundred patients ...
    • Prevalence and Overlap of Potential Embolic Sources in Patients With Embolic Stroke of Undetermined Source 

      Ntaios G., Perlepe K., Lambrou D., Sirimarco G., Strambo D., Eskandari A., Karagkiozi E., Vemmou A., Koroboki E., Manios E., Makaritsis K., Vemmos K., Michel P. (2019)
      Background: We aimed to assess the prevalence and degree of overlap of potential embolic sources (PES) in patients with embolic stroke of undetermined source (ESUS). Methods and Results: In a pooled data set derived from ...
    • Recurrent Ischemic Stroke and Bleeding in Patients With Atrial Fibrillation Who Suffered an Acute Stroke While on Treatment With Nonvitamin K Antagonist Oral Anticoagulants: The RENO-EXTEND Study 

      Paciaroni M., Caso V., Agnelli G., Mosconi M.G., Giustozzi M., Seiffge D.J., Engelter S.T., Lyrer P., Polymeris A.A., Kriemler L., Zietz A., Putaala J., Strbian D., Tomppo L., Michel P., Strambo D., Salerno A., Remillard S., Buehrer M., Bavaud O., Vanacker P., Zuurbier S., Yperzeele L., Loos C.M.J., Cappellari M., Emiliani A., Zedde M., Abdul-Rahim A., Dawson J., Cronshaw R., Schirinzi E., Del Sette M., Stretz C., Kala N., Reznik M., Schomer A., Grory B.M., Jayaraman M., Mctaggart R., Yaghi S., Furie K.L., Masotti L., Grifoni E., Toni D., Risitano A., Falcou A., Petraglia L., Lotti E.M., Padroni M., Pavolucci L., Lochner P., Silvestrelli G., Ciccone A., Alberti A., Venti M., Traballi L., Urbini C., Kargiotis O., Rocco A., Diomedi M., Marcheselli S., Caliandro P., Zauli A., Reale G., Antonenko K., Rota E., Tassinari T., Saia V., Palmerini F., Aridon P., Arnao V., Monaco S., Cottone S., Baldi A., D'Amore C., Ageno W., Pegoraro S., Ntaios G., Sagris D., Giannopoulos S., Kosmidou M., Ntais E., Romoli M., Pantoni L., Rosa S., Bertora P., Chiti A., Canavero I., Saggese C.E., Plocco M., Giorli E., Palaiodimou L., Bakola E., Tsivgoulis G., Bandini F., Gasparro A., Terruso V., Mannino M., Pezzini A., Ornello R., Sacco S., Popovic N., Scoditti U., Genovese A., Denti L., Flomin Y., Mancuso M., Ferrari E., Caselli M.C., Ulivi L., Giannini N., De Marchis G.M. (2022)
      BACKGROUND: In patients with atrial fibrillation who suffered an ischemic stroke while on treatment with nonvitamin K antagonist oral anticoagulants, rates and determinants of recurrent ischemic events and major bleedings ...
    • Risk Stratification for Recurrence and Mortality in Embolic Stroke of Undetermined Source 

      Ntaios G., Vemmos K., Lip G.Y.H., Koroboki E., Manios E., Vemmou A., Rodríguez-Campello A., Cuadrado-Godia E., Giralt-Steinhauer E., Arnao V., Caso V., Paciaroni M., Diez-Tejedor E., Fuentes B., Pérez Lucas J., Arauz A., Ameriso S.F., Hawkes M.A., Pertierra L., Gómez-Schneider M., Bandini F., Chavarria Cano B., Iglesias Mohedano A.M., García Pastor A., Gil-Núñez A., Putaala J., Tatlisumak T., Barboza M.A., Athanasakis G., Makaritsis K., Papavasileiou V. (2016)
      Background and Purpose - The risk of stroke recurrence in patients with Embolic Stroke of Undetermined Source (ESUS) is high, and the optimal antithrombotic strategy for secondary prevention is unclear. We investigated ...
    • Statin treatment and outcomes after embolic stroke of undetermined source 

      Sagris D., Perlepe K., Leventis I., Samara S., Manios E., Korompoki E., Makaritsis K., Milionis H., Vemmos K., Ntaios G. (2021)
      The association of low-density lipoprotein cholesterol lowering with outcomes in embolic stroke of undetermined source (ESUS) patients is unclear. In these patients we aimed to assess the effect of statin on stroke recurrence, ...
    • Stroke risk stratification in patients with heart failure and sinus rhythm 

      Sagris D., Shantsila E., Lip G.Y.H. (2022)
      [No abstract available]
    • Thrombolysis and thrombectomy in patients treated with dabigatran with acute ischemic stroke: Expert opinion 

      Diener H.C., Bernstein R., Butcher K., Campbell B., Cloud G., Davalos A., Davis S., Ferro J.M., Grond M., Krieger D., Ntaios G., Slowik A., Touzé E. (2017)
      Systemic thrombolysis with rt-PA is contraindicated in patients with acute ischemic stroke anticoagulated with dabigatran. This expert opinion provides guidance on the use of the specific reversal agent idarucizumab followed ...