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Αποτελέσματα 1-20 από 25

    • Benefits and Limitations of TKIs in Patients with Medullary Thyroid Cancer: A Systematic Review and Meta-Analysis 

      Efstathiadou Z.A., Tsentidis C., Bargiota A., Daraki V., Kotsa K., Ntali G., Papanastasiou L., Tigas S., Toulis K., Pazaitou-Panayiotou K., Alevizaki M. (2021)
      Introduction: Tyrosine kinase inhibitors (TKIs) have been used in patients with advanced medullary thyroid carcinoma (MTC); however, data on their effectiveness and safety are limited. The aim of this systematic review and ...

    • Cardio-Oncology Rehabilitation and Telehealth: Rationale for Future Integration in Supportive Care of Cancer Survivors 

      Batalik L., Filakova K., Radkovcova I., Dosbaba F., Winnige P., Vlazna D., Batalikova K., Felsoci M., Stefanakis M., Liska D., Papathanasiou J., Pokorna A., Janikova A., Rutkowski S., Pepera G. (2022)
      The direct toxicity of cancer treatment threatens patients and survivors with an increased risk of cardiovascular disease or adverse functional changes with subsequent progression of cardiovascular complications. An ...

    • Cardiotoxicity of Chemical Substances: An Emerging Hazard Class 

      Georgiadis N., Tsarouhas K., Dorne J.-L.C.M., Kass G.E.N., Laspa P., Toutouzas K., Koulaouzidou E.A., Kouretas D., Tsitsimpikou C. (2022)
      (1) Background: Human health risks and hazards from chemical substances are well regulated internationally. However, cardiotoxicity, is not defined as a stand-alone hazard and therefore there are no defined criteria for ...

    • Characteristics and outcomes of cancer patients who develop pulmonary embolism: A cross-sectional study 

      Chlapoutakis S., Georgakopoulou V.E., Trakas N., Kouvelos G., Papalexis P., Damaskos C., Sklapani P., Grivas A., Gouveris P., Tryfonopoulos D., Tzovaras A., Ardavanis-Loukeris G., Grouzi E., Spandidos D.A., Matsagkas M. (2021)
      Pulmonary embolism (PE), along with deep vein thrombosis, are collectively known as venous thromboembo- lism (VTE). Predisposing factors for PE include post-operative conditions, pregnancy, cancer and an advanced age; of ...

    • Chloroquine used in combination with chemotherapy synergistically suppresses growth and angiogenesis in vitro and in vivo 

      Gurel-Gurevin E., Tuba Kiyan H., Esener O.B.B., Aydinlik S., Uvez A., Ulukaya E., Dimas K., Armutak E.I. (2018)
      Background: The inhibition of autophagy using pharmacological inhibitors such as chloroquine may be an effective strategy to overcome chemotherapy or resistance to anti-angiogenic therapy. Materials and Methods: The cytotoxic ...

    • Dysregulation of caveolin-1 phosphorylation and nuclear translocation is associated with senescence onset 

      Goutas A., Outskouni Z., Papathanasiou I., Satra M., Koliakos G., Trachana V. (2021)
      We recently reported that the inability of osteoarthritic (OA) chondrocytes to repair oxidative stress (OS) induced DNA damage is linked to Cav-1 overexpression/improper localization. We speculated that the senescent status ...

    • Effects of combined administration of doxorubicin and chloroquine on lung pathology in mice with solid Ehrlich ascites carcinoma 

      Utkusavas A., Gurel Gurevin E., Yilmazer N., Uvez A., Oztay F., Bulut H., Ustunova S., Esener O.B.B., Sonmez K., Erol Kutucu D., Meral I., Dimas K., Armutak E.I. (2022)
      Combined use of a chemotherapeutic agent and an autophagy inhibitor is a novel cancer treatment strategy. We investigated the effects of chloroquine (CQ) on lung pathology caused by both solid Ehrlich ascites carcinoma ...

    • Ewing's sarcoma of the clavicle: A case report 

      Igoumenou V.G., Economopoulou P., Agrogiannis G., Dailiana Z., Mavrogenis A.F. (2018)
      There is a paucity of literature on the management of patients with Ewing's sarcoma of the clavicle, with few existing published papers. To enhance the literature, this article presents an adolescent with Ewing's sarcoma ...

    • High intratumoural accumulation of stealth® liposomal doxorubicin (Caelyx®) in glioblastomas and in metastatic brain tumours 

      Koukourakis, M. I.; Koukouraki, S.; Fezoulidis, I.; Kelekis, N.; Kyrias, G.; Archimandritis, S.; Karkavitsas, N. (2000)
      The blood-brain barrier is a major obstacle for the chemotherapeutic drugs to effectively reach primary or secondary brain tumours, Stealth® liposomal drugs are highly accumulated in tumoural tissues. In the present study ...

    • Identification of Very Low-Risk Subgroups of Patients with Primary Mediastinal Large B-Cell Lymphoma Treated with R-CHOP 

      Vassilakopoulos T.P., Michail M., Papageorgiou S., Kourti G., Angelopoulou M.K., Panitsas F., Sachanas S., Kalpadakis C., Katodritou E., Leonidopoulou T., Kotsianidis I., Hatzimichael E., Kotsopoulou M., Dimou M., Variamis E., Boutsis D., Terpos E., Dimopoulou M.N., Karakatsanis S., Michalis E., Karianakis G., Tsirkinidis P., Vadikolia C., Poziopoulos C., Pigaditou A., Vrakidou E., Economopoulos T., Kyriazopoulou L., Siakantaris M.P., Kyrtsonis M.-C., Symeonidis A., Anargyrou K., Papaioannou M., Hatjiharissi E., Vervessou E., Tsirogianni M., Palassopoulou M., Gainaru G., Stefanoudaki E., Zikos P., Tsirigotis P., Tsourouflis G., Assimakopoulou T., Konstantinidou P., A. Papadaki H., Megalakaki K., Dimopoulos M.-A., Pappa V., Karmiris T., Roussou P., Panayiotidis P., Konstantopoulos K., Pangalis G.A. (2021)
      Background: R-CHOP can cure approximately 75% of patients with primary mediastinal large B-cell lymphoma (PMLBCL), but prognostic factors have not been sufficiently evaluated yet. R-da- EPOCH is potentially more effective ...

    • Meta-analysis of BCOR rearranged sarcomas: challenging the therapeutic approach 

      Kyriazoglou A., Bagos P. (2021)
      Introduction: BCOR rearranged sarcomas comprise a group of malignant mesenchymal tumors that until recently were classified as Ewing sarcomas or as undifferentiated round cell sarcomas. The identification of alterations ...

    • Mortalin-mediated and ERK-controlled targeting of HIF-1α to mitochondria confers resistance to apoptosis under hypoxia 

      Mylonis I., Kourti M., Samiotaki M., Panayotou G., Simos G. (2017)
      Hypoxia inducible factor-1 (HIF-1) is the main transcriptional activator of the cellular response to hypoxia and an important target of anticancer therapy. Phosphorylation by ERK1 and/or ERK2 (MAPK3 and MAPK1, respectively; ...

    • Positron emission tomography after response to rituximab-CHOP in primary mediastinal large B-cell lymphoma: impact on outcomes and radiotherapy strategies 

      Vassilakopoulos T.P., Papageorgiou S.G., Angelopoulou M.K., Chatziioannou S., Prassopoulos V., Karakatsanis S., Arapaki M., Mellios Z., Sachanas S., Kalpadakis C., Katodritou E., Leonidopoulou T., Kotsianidis I., Hatzimichael E., Kotsopoulou M., Dimou M., Variamis E., Boutsis D., Terpos E., Michali E., Karianakis G., Tsirkinidis P., Vadikolia C., Poziopoulos C., Pigaditou A., Vrakidou E., Siakantaris M.P., Kyrtsonis M.-C., Symeonidis A., Anargyrou K., Papaioannou M., Chatziharissi E., Vervessou E., Tsirogianni M., Palassopoulou M., Gainaru G., Mainta C., Tsirigotis P., Assimakopoulou T., Konstantinidou P., Papadaki H., Dimopoulos M.-A., Pappa V., Karmiris T., Roussou P., Datseris I., Panayiotidis P., Konstantopoulos K., Pangalis G.A., Rondogianni P. (2021)
      End-of-treatment (EoT) PET/CT is used as a guide to omit radiotherapy (RT) patients with primary mediastinal large B-cell lymphoma (PMBCL). We present the mature and extended results of a retrospective study evaluating the ...

    • Primary extranodal non Hodgkin's lymphoma of the head and neck in adults: A clinicopathological comparison between tonsillar and non tonsillar lymphomas 

      Economopoulos, T.; Fountzilas, G.; Kostourou, A.; Daniilidis, J.; Pavlidis, N.; Andreopoulou, H.; Nicolaou, A.; Papageorgiou, E.; Mellou, S.; Dervenoulas, J.; Stathakis, N. (1998)
      Primary extranodal NHL of the head and neck (HN-NHL) accounts for 10-20% of all cases of NHL. Despite their frequency, the natural history and biological behaviour of these lymphomas is poorly understood. In this study we ...

    • Primary lymphomas of bone 

      Kitsoulis, P.; Vlychou, M.; Papoudou-Bai, A.; Karatzias, G.; Charchanti, A.; Agnantis, N. J.; Bai, M. (2006)
      Primary lymphomas of bone are uncommon malignancies. The vast majority of them are non-Hodgkin lymphoma (NHL), whereas primary Hodgkin lymphoma (HL) of bone is extremely rare. Patients with primary NHL of bone commonly ...

    • Primary retroperitoneal non-Hodgkin lymphoma presenting with torturous generalized pruritus in an elderly 

      Daponte, A.; Ioannou, M.; Gioti, C.; Kallitsaris, A.; Dalekos, G. N.; Messinis, I. E. (2007)
      Introduction: A case of a rare primary retroperitoneal non-Hodgkin lymphoma (NHL), which presented with torturous generalized pruritus in a 74-year-old female patient is reported Methods: Case report. Results: Explorative ...

    • The proteasome as a target for cancer treatment: Focus on bortezomib 

      Papandreou, C. N. (2005)
      Targeted degradation of key regulatory proteins is an essential element of cell-cycle control. The proteasome plays a pivotal role in the degradation of such proteins and has, therefore, become an important therapeutic ...

    • Radiotherapy of early breast cancer in scleroderma patients: Our experience with four cases and a short review of the literature 

      Kyrgias, G.; Theodorou, K.; Zygogianni, A.; Tsanadis, K.; Zervoudis, S.; Tzitzikas, J.; Koukourakis, M. (2012)
      Purpose: Connective vascular diseases (CVD), including scleroderma, are reported to represent for some researchers a relative contraindication and for others absolute contraindication for radiotherapy. The purpose of our ...

    • Real-life Experience With Rituximab-CHOP Every 21 or 14 Days in Primary Mediastinal Large B-cell Lymphoma 

      Karakatsanis S.J., Bouzani M., Symeonidis A., Angelopoulou M.K., Papageorgiou S.G., Michail M., Gainaru G., Kourti G., sachanas S., Kalpadakis C., Katodritou E., Leonidopoulou T., Kotsianidis I., Hatzimichael E., Kotsopoulou M., Dimou M., Variamis E., Boutsis D., Kanellias N., Dimopoulou M.N., Michali E., Karianakis G., Tsirkinidis P., Vadikolia C., Poziopoulos C., Pigaditou A., Vrakidou E., Economopoulos T., Kyriazopoulou L., Siakantaris M.P., Kyrtsonis M.-C., Anargyrou K., Papaioannou M., Hatjiharissi E., Vervessou E., Tsirogianni M., Palassopoulou M., Stefanoudaki E., Zikos P., Tsirigotis P., Tsourouflis G., Assimakopoulou T., Verrou E., Papadaki H., Lampropoulou P., Dimopoulos M.-A., Pappa V., Konstantopoulos K., Karmiris T., Roussou P., Panayiotidis P., Pangalis G.A., Vassilakopoulos T.P. (2022)
      Background/Aim: Primary mediastinal large Bcell lymphoma (PMLBCL) is an aggressive B-cell non- Hodgkin lymphoma (NHL), whose prognosis has greatly improved since the incorporation of the anti-CD20 monoclonal antibody ...

    • The role of MiRNA-21 in gliomas: Hope for a novel therapeutic intervention? 

      Aloizou A.-M., Pateraki G., Siokas V., Mentis A.-F.A., Liampas I., Lazopoulos G., Kovatsi L., Mitsias P.D., Bogdanos D.P., Paterakis K., Dardiotis E. (2020)
      Gliomas are the most common primary brain tumors in adults. They are generally very resistant to treatment and are therefore associated with negative outcomes. MicroRNAs (miRNAs) are small, non-coding RNA molecules that ...