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    • Absence of linkage to chromosomes 6q and 16p in a Greek population with knee osteoarthritis 

      Tsezou, A.; Karachalios, T.; Fytili, P.; Giannatou, E.; Christodoulou, K.; Hadjigeorgiou, G. M.; Malizos, K. N. (2006)
      Osteoarthritis (OA) is a common age-related debilitating disease of the joints characterized by degeneration of the articular cartilage which leads to joint pain, discomfort, and immobility. Several risk factors have been ...

    • Assessment of Parkinson's disease risk loci in Greece 

      Kara, E.; Xiromerisiou, G.; Spanaki, C.; Bozi, M.; Koutsis, G.; Panas, M.; Dardiotis, E.; Ralli, S.; Bras, J.; Letson, C.; Edsall, C.; Pliner, H.; Arepalli, S.; Kalinderi, K.; Fidani, L.; Bostantjopoulou, S.; Keller, M. F.; Wood, N. W.; Hardy, J.; Houlden, H.; Stefanis, L.; Plaitakis, A.; Hernandez, D.; Hadjigeorgiou, G. M.; Nalls, M. A.; Singleton, A. B. (2014)
      Genome-wide association studies (GWAS) have been shown to be a powerful approach to identify risk loci for neurodegenerative diseases. Recent GWAS in Parkinson's disease (PD) have been successful in identifying numerous ...

    • The c.504T > C (p.Asn168Asn) polymorphism in the ABCB4 gene as a predisposing factor for intrahepatic cholestasis of pregnancy in Greece 

      Kitsiou-Tzeli, S.; Traeger-Synodinos, J.; Giannatou, E.; Kaminopetros, P.; Roma, E.; Makrythanasis, P.; Tsezou, A. (2010)

    • Detection of hybrids between wild boars (Sus scrofa scrofa) and domestic pigs (Sus scrofa f. domestica) in Greece, using the PCR-RFLP method on melanocortin-1 receptor (MC1R) mutations 

      Koutsogiannouli, E. A.; Moutou, K. A.; Sarafidou, T.; Stamatis, C.; Mamuris, Z. (2010)
      The melanocortin-1 receptor (MC1R) regulates melanogenesis in mammals within the mammalian melanocyte and the hair follicle. Common variations (polymorph isms) in the MC1R gene are associated with normal differences in ...

    • Genetic assessment of familial and early-onset Parkinson's disease in a Greek population 

      Bozi, M.; Papadimitriou, D.; Antonellou, R.; Moraitou, M.; Maniati, M.; Vassilatis, D. K.; Papageorgiou, S. G.; Leonardos, A.; Tagaris, G.; Malamis, G.; Theofilopoulos, D.; Kamakari, S.; Stamboulis, E.; Hadjigeorgiou, G. M.; Athanassiadou, A.; Michelakakis, H.; Papadimitriou, A.; Gasser, T.; Stefanis, L. (2014)
      Background and purpose Although the first mutation associated with Parkinson's disease (PD) was identified several years ago in the alpha-synuclein (SNCA) gene in families of Greek and Italian ancestry, a more systematic ...

    • Genetic factors influencing outcome from neurotrauma 

      Dardiotis, E.; Grigoriadis, S.; Hadjigeorgiou, G. M. (2012)
      Purpose of review Clinical outcome after neurotrauma is considerably variable and can only partly be explained by known prognostic factors. There is converging evidence from genetic research that a number of genetic variants ...

    • Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture 

      Estrada, K.; Styrkarsdottir, U.; Evangelou, E.; Hsu, Y. H.; Duncan, E. L.; Ntzani, E. E.; Oei, L.; Albagha, O. M. E.; Amin, N.; Kemp, J. P.; Koller, D. L.; Li, G.; Liu, C. T.; Minster, R. L.; Moayyeri, A.; Vandenput, L.; Willner, D.; Xiao, S. M.; Yerges-Armstrong, L. M.; Zheng, H. F.; Alonso, N.; Eriksson, J.; Kammerer, C. M.; Kaptoge, S. K.; Leo, P. J.; Thorleifsson, G.; Wilson, S. G.; Wilson, J. F.; Aalto, V.; Alen, M.; Aragaki, A. K.; Aspelund, T.; Center, J. R.; Dailiana, Z.; Duggan, D. J.; Garcia, M.; Garcia-Giralt, N.; Giroux, S.; Hallmans, G.; Hocking, L. J.; Husted, L. B.; Jameson, K. A.; Khusainova, R.; Kim, G. S.; Kooperberg, C.; Koromila, T.; Kruk, M.; Laaksonen, M.; Lacroix, A. Z.; Lee, S. H.; Leung, P. C.; Lewis, J. R.; Masi, L.; Mencej-Bedrac, S.; Nguyen, T. V.; Nogues, X.; Patel, M. S.; Prezelj, J.; Rose, L. M.; Scollen, S.; Siggeirsdottir, K.; Smith, A. V.; Svensson, O.; Trompet, S.; Trummer, O.; van Schoor, N. M.; Woo, J.; Zhu, K.; Balcells, S.; Brandi, M. L.; Buckley, B. M.; Cheng, S. L.; Christiansen, C.; Cooper, C.; Dedoussis, G.; Ford, I.; Frost, M.; Goltzman, D.; Gonzalez-Macias, J.; Kahonen, M.; Karlsson, M.; Khusnutdinova, E.; Koh, J. M.; Kollia, P.; Langdahl, B. L.; Leslie, W. D.; Lips, P.; Ljunggren, O.; Lorenc, R. S.; Marc, J.; Mellstrom, D.; Obermayer-Pietsch, B.; Olmos, J. M.; Pettersson-Kymmer, U.; Reid, D. M.; Riancho, J. A.; Ridker, P. M.; Rousseau, F.; Slagboom, P. E.; Tang, N. L. S.; Urreizti, R.; Van Hul, W.; Viikari, J.; Zarrabeitia, M. T.; Aulchenko, Y. S.; Castano-Betancourt, M.; Grundberg, E.; Herrera, L.; Ingvarsson, T.; Johannsdottir, H.; Kwan, T.; Li, R.; Luben, R.; Medina-Gomez, C.; Palsson, S. T.; Reppe, S.; Rotter, J. I.; Sigurdsson, G.; van Meurs, J. B. J.; Verlaan, D.; Williams, F. M. K.; Wood, A. R.; Zhou, Y. H.; Gautvik, K. M.; Pastinen, T.; Raychaudhuri, S.; Cauley, J. A.; Chasman, D. I.; Clark, G. R.; Cummings, S. R.; Danoy, P.; Dennison, E. M.; Eastell, R.; Eisman, J. A.; Gudnason, V.; Hofman, A.; Jackson, R. D.; Jones, G.; Jukema, J. W.; Khaw, K. T.; Lehtimaki, T.; Liu, Y. M.; Lorentzon, M.; McCloskey, E.; Mitchell, B. D.; Nandakumar, K.; Nicholson, G. C.; Oostra, B. A.; Peacock, M.; Pols, H. A. P.; Prince, R. L.; Raitakari, O.; Reid, I. R.; Robbins, J.; Sambrook, P. N.; Sham, P. C.; Shuldiner, A. R.; Tylavsky, F. A.; van Duijn, C. M.; Wareham, N. J.; Cupples, L. A.; Econs, M. J.; Evans, D. M.; Harris, T. B.; Kung, A. W. C.; Psaty, B. M.; Reeve, J.; Spector, T. D.; Streeten, E. A.; Zillikens, M. C.; Thorsteinsdottir, U.; Ohlsson, C.; Karasik, D.; Richards, J. B.; Brown, M. A.; Stefansson, K.; Uitterlinden, A. G.; Ralston, S. H.; Ioannidis, J. P. A.; Kiel, D. P.; Rivadeneira, F. (2012)
      Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 ...

    • Genomic analysis of recombinant Sabin clinical isolates 

      Paximadi, E.; Karakasiliotis, I.; Mamuris, Z.; Stathopoulos, C.; Krikelis, V.; Markoulatos, P. (2006)
      Recombination in Poliovirus vaccine strains is a very frequent phenomenon. In this report 23 polio/Sabin strains isolated from healthy vaccinees or from VAPP patients after OPV administration, were investigated in order ...

    • Genomic Convergence of Genome-wide Investigations for Complex Traits 

      Kitsios, G. D.; Zintzaras, E. (2009)
      Genome-wide investigations for identifying the genes for complex traits are considered to be agnostic in terms of prior assumptions for the responsible DNA alterations. The agreement of genome-wide association studies ...

    • HLA-C, CSTA and DS12346 susceptibility alleles confer over 100-fold increased risk of developing psoriasis: evidence of gene interaction 

      Vasilopoulos, Y.; Sagoo, G. S.; Cork, M. J.; Walters, K.; Tazi-Ahnini, R. (2011)
      Psoriasis is an inflammatory skin disorder that exhibits multifactorial mode of inheritance. In addition to the well-known susceptibility locus PSORS1 many other loci have been shown to be implicated in the genetic ...

    • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease 

      Nalls, M. A.; Pankratz, N.; Lill, C. M.; Do, C. B.; Hernandez, D. G.; Saad, M.; DeStefano, A. L.; Kara, E.; Bras, J.; Sharma, M.; Schulte, C.; Keller, M. F.; Arepalli, S.; Letson, C.; Edsall, C.; Stefansson, H.; Liu, X.; Pliner, H.; Lee, J. H.; Cheng, R.; Ikram, M. A.; Ioannidis, J. P. A.; Hadjigeorgiou, G. M.; Bis, J. C.; Martinez, M.; Perlmutter, J. S.; Goate, A.; Marder, K.; Fiske, B.; Sutherland, M.; Xiromerisiou, G.; Myers, R. H.; Clark, L. N.; Stefansson, K.; Hardy, J. A.; Heutink, P.; Chen, H.; Wood, N. W.; Houlden, H.; Payami, H.; Brice, A.; Scott, W. K.; Gasser, T.; Bertram, L.; Eriksson, N.; Foroud, T.; Singleton, A. B.; Ipdg; Parkins, G. Parkinson's Study Grp PSG; AndMe; GenePd; Ngrc; Hihg; Ashkenazi Jewish Dataset, Investiga; Charge; Nabec; Ukbec; Greek Parkinson's Dis, Consortium; Alzheimer Genetic Analysis, Gr (2014)
      We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide ...

    • Large-scale population genetic analysis for hemoglobinopathies reveals different mutation spectra in central Greece compared to the rest of the country 

      Samara, M.; Chiotoglou, I.; Kalamaras, A.; Likousi, S.; Chassanidis, C.; Vagena, A.; Vagenas, C.; Eftichiadis, E.; Vamvakopoulos, N.; Patrinos, G. P.; Kollia, P. (2007)
      We have undertaken a large population screening study to identify the molecular basis of hemoglobinopathies in the central Greece region. A total of 845 unrelated beta-thalassemia patients and alpha-, beta-, and delta ...

    • A large-scale replication study for the association of rs17039192 in HIF-2 alpha with knee osteoarthritis 

      Nakajima, M.; Shi, D. Q.; Dai, J.; Tsezou, A.; Zheng, M. H.; Norman, P. E.; Chou, C. H.; Lee, M. T. M.; Hwang, J. Y.; Kim, D. H.; Takahashi, A.; Ikegawa, S.; Jiang, Q. (2012)
      Osteoarthritis (OA) is a common disease with a genetic component for its etiology. Recently, a genetic association of a single nucleotide polymorphism (SNP), rs17039192 in HIF-2a with knee OA has been reported in a Japanese ...

    • Novel Sequence Variations in the CER1 Gene Are Strongly Associated with Low Bone Mineral Density and Risk of Osteoporotic Fracture in Postmenopausal Women 

      Koromila, T.; Dailiana, Z.; Samara, S.; Chassanidis, C.; Tzavara, C.; Patrinos, G. P.; Aleporou-Marinou, V.; Kollia, P. (2012)
      Osteoporosis is a common skeletal disease characterized by a combination of low bone mass and increased fragility. In this case-control study, we investigated the possible association of two novel candidate genes, CER1 and ...

    • Prognostic impact of tumor volumetry in patients with locally advanced head-and-neck carcinoma (non-nasopharyngeal) treated by radiotherapy alone or combined radiochemotherapy in a randomized trial 

      Plataniotis, G. A.; Theofanopoulou, M. E.; Kalogera-Fountzila, A.; Haritanti, A.; Ciuleanou, E.; Ghilezan, N.; Zamboglou, N.; Dimitriadis, A.; Sofroniadis, I.; Fountzilas, G. (2004)
      Purpose: Tumor volume (TV) is one of the main reported factors determining the outcome of treatment in head-and-neck carcinomas. In this study, the prognostic impact of TV was explored in the context of a randomized trial ...

    • RANTES promoter gene polymorphisms and susceptibility to severe respiratory syncytial virus-induced bronchiolitis 

      Amanatidou, V.; Sourvinos, G.; Apostolakis, S.; Neonaki, P.; Tsilimigaki, A.; Krambovitis, E.; Spandidos, D. A. (2008)
      Background: Severe respiratory syncytial virus (RSV) infection is characterized by enhanced chemokine activity. Several studies have linked increased regulated on activation, normal T cell expressed and secreted (RANTES) ...

    • Single-Locus-Sequence-Based Typing of bla(OXA-51-like) Genes for Rapid Assignment of Acinetobacter baumannii Clinical Isolates to International Clonal Lineages 

      Pournaras, S.; Gogou, V.; Giannouli, M.; Dimitroulia, E.; Dafopoulou, K.; Tsakris, A.; Zarrilli, R. (2014)
      Single-locus bla(OXA-51-like) sequence-based typing (SBT) was evaluated for its ability to determine correctly sequence types (STs) in Acinetobacter baumannii clinical isolates, in comparison with the Pasteur's multilocus ...

    • TNFRSF13B/TACI Alterations in Greek Patients with Antibody Deficiencies 

      Speletas, M.; Mamara, A.; Papadopoulou-Alataki, E.; Iordanakis, G.; Liadaki, K.; Bardaka, F.; Kanariou, M.; Germenis, A. E. (2011)
      TNFRSF13B/TACI defects have recently been associated with common variable immunodeficiency (CVID) pathogenesis. Considering that TNFRSF13B/TACI is very polymorphic and the frequency of its alterations may be different in ...