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    • Association of a BMP5 microsatellite with knee osteoarthritis: case-control study 

      Rodriguez-Fontenla, C.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Loughlin, J.; Gonzalez, A. (2012)
      Introduction: We aimed to explore the involvement of a multiallelic functional polymorphism in knee osteoarthritis (OA) susceptibility as a prototype of possible genetic factors escaping GWAS detection. Methods: OA patients ...

    • Association of renin-angiotensin system and natriuretic peptide receptor A gene polymorphisms with hypertension in a Hellenic population 

      Tsezou, A.; Karayannis, G.; Giannataou, E.; Papanikolaou, V.; Triposkiadis, F. (2008)
      Introduction. Hypertension results from the interaction of genetic and environmental factors. Since the renin-angiotensin and the natriuretic peptide systems contribute to blood pressure regulation, variations in the ...

    • Duplicate record detection: A survey 

      Elmagarmid, A. K.; Ipeirotis, P. G.; Verykios, V. S. (2007)
      Often, in the real world, entities have two or more representations in databases. Duplicate records do not share a common key and/or they contain errors that make duplicate matching a difficult task. Errors are introduced ...

    • Effects of interaction between angiotensin I-converting enzyme polymorphisms and lifestyle on adiposity in adolescent Greeks 

      Moran, C. N.; Vassilopoulos, C.; Tsiokanos, A.; Jamurtas, A. Z.; Bailey, M. E. S.; Wilson, R. H.; Pitsiladis, Y. P. (2005)
      Genetic variation in the human angiotensin I-converting enzyme (ACE) gene has been associated with many heritable traits, including obesity. Herein, we report the results of a study of obesity-related phenotypes and lifestyle ...

    • Family-based association study of the loci 2 and 3 in a European restless legs syndrome population 

      Kemlink, D.; Polo, O.; Montagna, P.; Provini, F.; Stiasny-Kolster, K.; Oertel, W.; de Weerd, A.; Nevsimalova, S.; Sonka, K.; Hogl, B.; Frauscher, B.; Poewe, W.; Trenkwalder, C.; Pramstaller, P. P.; Ferini-Strambi, L.; Zucconi, M.; Konofal, E.; Arnulf, I.; Hadjigeorgiou, G. M.; Happe, S.; Klein, C.; Hiller, A.; Lichtner, P.; Meitinger, T.; Muller-Myshok, B.; Winkelmann, J. (2007)
      Three loci for the restless legs syndrome (RLS) on chromosomes 12q, 14q, and 9p (RLS 1, RLS2, and RLS3) have been mapped, but no gene has been identified as yet. RLS1 has been confirmed in families from three different ...

    • Genetic model selection in genome-wide association studies: robust methods and the use of meta-analysis 

      Bagos, P. G. (2013)
      In genetic association studies (GAS) as well as in genome-wide association studies (GWAS), the mode of inheritance (dominant, additive and recessive) is usually not known a priori. Assuming an incorrect mode of inheritance ...

    • Genetics of restless legs syndrome (RLS): State-of-the-art and future directions 

      Winkelmann, J.; Polo, O.; Provini, F.; Nevsimalova, S.; Kemlink, D.; Sonka, K.; Hogl, B.; Poewe, W.; Stiasny-Kolster, K.; Oertel, W.; de Weerd, A.; Strambi, L. F.; Zucconi, M.; Pramstaller, P. P.; Arnulf, I.; Trenkwalder, C.; Klein, C.; Hadjigeorgiou, G. M.; Happe, S.; Rye, D.; Montagna, P. (2007)
      Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no ...

    • Genomic Convergence of Genome-wide Investigations for Complex Traits 

      Kitsios, G. D.; Zintzaras, E. (2009)
      Genome-wide investigations for identifying the genes for complex traits are considered to be agnostic in terms of prior assumptions for the responsible DNA alterations. The agreement of genome-wide association studies ...

    • HEGESMA: genome search meta-analysis and heterogeneity testing 

      Zintzaras, E.; Ioannidis, J. P. A. (2005)
      Heterogeneity and genome search meta-analysis (HEGESMA) is a comprehensive software for performing genome scan meta-analysis, a quantitative method to identify genetic regions (bins) with consistently increased linkage ...

    • A heterogeneity-based genome search meta-analysis for autism-spectrum disorders 

      Trikalinos, T. A.; Karvouni, A.; Zintzaras, E.; Ylisaukko-oja, T.; Peltonen, L.; Jarvela, I.; Ioannidis, J. P. A. (2006)
      Autism and autism-spectrum disorders exhibit high heritability, although specific susceptibility genes still remain largely elusive. We performed a heterogeneity-based genome search meta-analysis (HEGESMA) of nine genome ...

    • Heterogeneity-based genome search meta-analysis for preeclampsia 

      Zintzaras, E.; Kitsios, G.; Harrison, G. A.; Laivuori, H.; Kivinen, K.; Kere, J.; Messinis, I.; Stefanidis, I.; Ioannidis, J. P. A. (2006)
      Preeclampsia is a pregnancy-related disorder that causes maternal and fetal morbidity and mortality. Its exact inheritance pattern is still unknown, and genome searches for identifying susceptibility loci for preeclampsia ...

    • Polymorphisms and haplotypes in MyD88 are associated with the development of sarcoidosis: a candidate-gene association study 

      Daniil, Z.; Mollaki, V.; Malli, F.; Koutsokera, A.; Antoniou, K. M.; Rodopoulou, P.; Gourgoulianis, K.; Zintzaras, E.; Vassilopoulos, G. (2013)
      Sarcoidosis is considered as a disorder of protracted immune response to an as yet unidentified causative agent that leads to granuloma formation. Material from M. tuberculosis and P. acne has been repeatedly detected in ...