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Πλοήγηση ανά Θέμα "DISCOVERY"

Αποτελέσματα 1-9 από 9

    • Evaluation of Current Prognostic and Predictive Markers in Breast Cancer: A Validation Study of Tissue Microarrays 

      Batistatou, A.; Televantou, D.; Bobos, M.; Eleftheraki, A. G.; Kouvaras, E.; Chrisafi, S.; Koukoulis, G. K.; Malamou-Mitsi, V.; Fountzilas, G. (2013)
      Background: Tissue microarrays (TMAs) are an attractive alternative to analysis of whole sections (WS). For breast carcinomas, the recent recommendations for cut-offs (i.e. Ki67, H-score) have necessitated the re-evaluation ...

    • EXACT KNOWLEDGE HIDING IN TRANSACTIONAL DATABASES 

      Gkoulalas-Divanis, A.; Verykios, V. S. (2009)
      The hiding of sensitive knowledge in the form of frequent itemsets, has gained increasing attention over the past years. This paper highlights the process of border revision, which is essential for the identification of ...

    • Glycogen Phosphorylase as a Target for Type 2 Diabetes: Synthetic, Biochemical, Structural and Computational Evaluation of Novel N-acyl-N '-(beta-D-glucopyranosyl) Urea Inhibitors 

      Kantsadi, A. L.; Parmenopoulou, V.; Bakalov, D. N.; Snelgrove, L.; Stravodimos, G. A.; Chatzileontiadou, D. S. M.; Manta, S.; Panagiotopoulou, A.; Hayes, J. M.; Komiotis, D.; Leonidas, D. D. (2015)
      Glycogen phosphorylase (GP), a validated target for the development of anti-hyperglycaemic agents, has been targeted for the design of novel glycopyranosylamine inhibitors. Exploiting the two most potent inhibitors from ...

    • Insecticidal effect of spinetoram against six major stored grain insect species 

      Vassilakos, T. N.; Athanassiou, C. G.; Saglam, O.; Chloridis, A. S.; Dripps, J. E. (2012)
      Spinetoram is a novel insecticide that belongs to the spinosyn class of insecticidal chemicals. The efficacy of spinetoram against numerous insect pest species in a variety of field crops has been well demonstrated. However, ...

    • Key challenges for the creation and maintenance of specialist protein resources 

      Holliday, G. L.; Bairoch, A.; Bagos, P. G.; Chatonnet, A.; Craik, D. J.; Finn, R. D.; Henrissat, B.; Landsman, D.; Manning, G.; Nagano, N.; O'Donovan, C.; Pruitt, K. D.; Rawlings, N. D.; Saier, M.; Sowdhamini, R.; Spedding, M.; Srinivasan, N.; Vriend, G.; Babbitt, P. C.; Bateman, A. (2015)
      As the volume of data relating to proteins increases, researchers rely more and more on the analysis of published data, thus increasing the importance of good access to these data that vary from the supplemental material ...

    • A MaxMin approach for hiding frequent itemsets 

      Moustakides, G. V.; Verykios, V. S. (2008)
      In this paper, we are proposing a new algorithmic approach for sanitizing raw data from sensitive knowledge in the context of mining of association rules. The new approach (a) relies on the maxmin criterion which is a ...

    • Optimization of Non-ATP Competitive CDK/Cyclin Groove Inhibitors through REPLACE-Mediated Fragment Assembly 

      Liu, S.; Premnath, P. N.; Bolger, J. K.; Perkins, T. L.; Kirkland, L. O.; Kontopidis, G.; McInnes, C. (2013)
      A major challenge in drug discovery is to develop and improve methods for targeting protein-protein interactions. Further exemplification of the REPLACE (REplacement with Partial Ligand Alternatives through Computational ...

    • Survey on Grid Resource Allocation Mechanisms 

      Qureshi, M. B.; Dehnavi, M. M.; Min-Allah, N.; Qureshi, M. S.; Hussain, H.; Rentifis, I.; Tziritas, N.; Loukopoulos, T.; Khan, S. U.; Xu, C. Z.; Zomaya, A. Y. (2014)
      Grid is a distributed high performance computing paradigm that offers various types of resources (like computing, storage, communication) to resource-intensive user tasks. These tasks are scheduled to allocate available ...

    • Synthesis and biological evaluation of potential small molecule inhibitors of tumor necrosis factor 

      Papaneophytou, C.; Alexiou, P.; Papakyriakou, A.; Ntougkos, E.; Tsiliouka, K.; Maranti, A.; Liepouri, F.; Strongilos, A.; Mettou, A.; Couladouros, E.; Eliopoulos, E.; Douni, E.; Kollias, G.; Kontopidis, G. (2015)
      Inhibition of tumor necrosis factor (TNF) production or function by small molecules has become a major focus in the pharmaceutical industry for the treatment of rheumatoid arthritis. In this study, a series of 39 novel ...