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    • Age-dependent changes in 8-oxoguanine-DNA glycosylase activity are modulated by adaptive responses to physical exercise in human skeletal muscle 

      Radak, Z.; Bori, Z.; Koltai, E.; Fatouros, I. G.; Jamurtas, A. Z.; Douroudos, II; Terzis, G.; Nikolaidis, M. G.; Chatzinikolaou, A.; Sovatzidis, A.; Kumagai, S.; Naito, H.; Boldogh, I. (2011)
      8-Oxo-7,8-dihydroguanine (8-oxoG) accumulates in the genome over time and is believed to contribute to the development of aging characteristics of skeletal muscle and various aging-related diseases. Here, we show a ...

    • eIF2 alpha Kinase PKR Modulates the Hypoxic Response by Stat3-Dependent Transcriptional Suppression of HIF-1 alpha 

      Papadakis, A. I.; Paraskeva, E.; Peidis, P.; Muaddi, H.; Li, S. Y.; Raptis, L.; Pantopoulos, K.; Simos, G.; Koromilas, A. E. (2010)
      Hypoxia within the tumor microenvironment promotes angiogenesis, metabolic reprogramming, and tumor progression. In addition to activating hypoxia-inducible factor-1 alpha (HIF-1 alpha), cells also respond to hypoxia by ...

    • Interplay between protein carbonylation and nitrosylation in plants 

      Lounifi, I.; Arc, E.; Molassiotis, A.; Job, D.; Rajjou, L.; Tanou, G. (2013)
      ROS and reactive nitrogen species (RNS) are key regulators of redox homeostasis in living organisms including plants. As control of redox homeostasis plays a central function in plant biology, redox proteomics could help ...

    • The molecular biology of the olive fly comes of age 

      Sagri, E.; Reczko, M.; Tsoumani, K. T.; Gregoriou, M. E.; Harokopos, V.; Mavridou, A. M.; Tastsoglou, S.; Athanasiadis, K.; Ragoussis, J.; Mathiopoulos, K. D. (2014)
      Background: Olive cultivation blends with the history of the Mediterranean countries since ancient times. Even today, activities around the olive tree constitute major engagements of several people in the countryside of ...

    • Regulation of the autophagic machinery in human neutrophils 

      Mitroulis, I.; Kourtzelis, I.; Kambas, K.; Rafail, S.; Chrysanthopoulou, A.; Speletas, M.; Ritis, K. (2010)
      The induction of the autophagy machinery, a process for the catabolism of cytosolic proteins and organelles, constitutes a crucial mechanism in innate immunity. However, the involvement of autophagy in human neutrophils ...