Πλοήγηση ανά Θέμα "ACTIVE-SITE"
Αποτελέσματα 1-3 από 3
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Competitive Inhibition of Human Poly(A)-Specific Ribonuclease (PARN) by Synthetic Fluoro-Pyranosyl Nucleosides
(2009)Poly(A)-specific ribonuclease (PARN) is a cap-interacting deadenylase that mediates, together with other exonucleases, the eukaryotic mRNA turnover and thus is actively involved in the regulation of gene expression. ... -
Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis
(2009)Poly(A)-specific ribonuclease (PARN) is a cap-interacting and poly(A)-specific 3'-exoribonuclease that efficiently degrades mRNA poly(A) tails. Based on the enzyme's preference for its natural substrates, we examined the ... -
Inhibitor design for ribonuclease A: the binding of two 5 '-phosphate uridine analogues
(2009)In the quest for the rational design of selective and potent inhibitors for members of the pancreatic ribonuclease A (RNase A) family of biomedical interest, the binding of uridine 5'-phosphate (U5P) and uridine 5'-diphosphate ...