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    • AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders 

      Salpietro V., Dixon C.L., Guo H., Bello O.D., Vandrovcova J., Efthymiou S., Maroofian R., Heimer G., Burglen L., Valence S., Torti E., Hacke M., Rankin J., Tariq H., Colin E., Procaccio V., Striano P., Mankad K., Lieb A., Chen S., Pisani L., Bettencourt C., Männikkö R., Manole A., Brusco A., Grosso E., Ferrero G.B., Armstrong-Moron J., Gueden S., Bar-Yosef O., Tzadok M., Monaghan K.G., Santiago-Sim T., Person R.E., Cho M.T., Willaert R., Yoo Y., Chae J.-H., Quan Y., Wu H., Wang T., Bernier R.A., Xia K., Blesson A., Jain M., Motazacker M.M., Jaeger B., Schneider A.L., Boysen K., Muir A.M., Myers C.T., Gavrilova R.H., Gunderson L., Schultz-Rogers L., Klee E.W., Dyment D., Osmond M., Parellada M., Llorente C., Gonzalez-Peñas J., Carracedo A., Van Haeringen A., Ruivenkamp C., Nava C., Heron D., Nardello R., Iacomino M., Minetti C., Skabar A., Fabretto A., Hanna M.G., Bugiardini E., Hostettler I., O’Callaghan B., Khan A., Cortese A., O’Connor E., Yau W.Y., Bourinaris T., Kaiyrzhanov R., Chelban V., Madej M., Diana M.C., Vari M.S., Pedemonte M., Bruno C., Balagura G., Scala M., Fiorillo C., Nobili L., Malintan N.T., Zanetti M.N., Krishnakumar S.S., Lignani G., Jepson J.E.C., Broda P., Baldassari S., Rossi P., Fruscione F., Madia F., Traverso M., De-Marco P., Pérez-Dueñas B., Munell F., Kriouile Y., El-Khorassani M., Karashova B., Avdjieva D., Kathom H., Tincheva R., Van-Maldergem L., Nachbauer W., Boesch S., Gagliano A., Amadori E., Goraya J.S., Sultan T., Kirmani S., Ibrahim S., Jan F., Mine J., Banu S., Veggiotti P., Zuccotti G.V., Ferrari M.D., Van Den Maagdenberg A.M.J., Verrotti A., Marseglia G.L., Savasta S., Soler M.A., Scuderi C., Borgione E., Chimenz R., Gitto E., Dipasquale V., Sallemi A., Fusco M., Cuppari C., Cutrupi M.C., Ruggieri M., Cama A., Capra V., Mencacci N.E., Boles R., Gupta N., Kabra M., Papacostas S., Zamba-Papanicolaou E., Dardiotis E., Maqbool S., Rana N., Atawneh O., Lim S.Y., Shaikh F., Koutsis G., Breza M., Coviello D.A., Dauvilliers Y.A., AlKhawaja I., AlKhawaja M., Al-Mutairi F., Stojkovic T., Ferrucci V., Zollo M., Alkuraya F.S., Kinali M., Sherifa H., Benrhouma H., Turki I.B.Y., Tazir M., Obeid M., Bakhtadze S., Saadi N.W., Zaki M.S., Triki C.C., Benfenati F., Gustincich S., Kara M., Belcastro V., Specchio N., Capovilla G., Karimiani E.G., Salih A.M., Okubadejo N.U., Ojo O.O., Oshinaike O.O., Oguntunde O., Wahab K., Bello A.H., Abubakar S., Obiabo Y., Nwazor E., Ekenze O., Williams U., Iyagba A., Taiwo L., Komolafe M., Senkevich K., Shashkin C., Zharkynbekova N., Koneyev K., Manizha G., Isrofilov M., Guliyeva U., Salayev K., Khachatryan S., Rossi S., Silvestri G., Haridy N., Ramenghi L.A., Xiromerisiou G., David E., Aguennouz M., Fidani L., Spanaki C., Tucci A., Raspall-Chaure M., Chez M., Tsai A., Fassi E., Shinawi M., Constantino J.N., De Zorzi R., Fortuna S., Kok F., Keren B., Bonneau D., Choi M., Benzeev B., Zara F., Mefford H.C., Scheffer I.E., Clayton-Smith J., Macaya A., Rothman J.E., Eichler E.E., Kullmann D.M., Houlden H., SYNAPS Study Group (2019)
      AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at ...

    • Association between Motor Signs and Cognitive Performance in Cognitively Unimpaired Older Adults: A Cross-Sectional Study Using the NACC Database 

      Siokas V., Liampas I., Lyketsos C.G., Dardiotis E. (2022)
      Aiming to examine whether specific motor signs are associated with worse performance in specific cognitive domains among cognitively unimpaired (CU) individuals, we performed a cross-sectional analysis of data from the ...

    • CADASIL in Greece: Mutational spectrum and clinical characteristics based on a systematic review and pooled analysis of published cases 

      Paraskevas G.P., Stefanou M.I., Constantinides V.C., Bakola E., Chondrogianni M., Giannopoulos S., Kararizou E., Boufidou F., Zompola C., Tsantzali I., Theodorou A., Palaiodimou L., Vikelis M., Lachanis S., Papathanasiou M., Bakirtzis C., Koutroulou I., Karapanayiotides T., Xiromerisiou G., Kapaki E., Tsivgoulis G. (2022)
      Background: Differences have been noted in the clinical presentation and mutational spectrum of CADASIL among various geographical areas. The aim of the present study was to investigate the mode of clinical presentation ...

    • Cerebellar stimulation in the management of medically intractable epilepsy: a systematic and critical review 

      Fountas, K. N.; Kapsalaki, E.; Hadjigeorgiou, G. (2010)
      Object. The wide application of deep brain stimulation in the management of movement as well as other degenerative neurological and psychiatric disorders has renewed the interest in using deep brain stimulation in the ...

    • Combined anterior and posterior shoulder dislocation as a manifestation of a brain tumour 

      Tsionos, I.; Karahalios, T.; Zibis, A. H.; Malizos, K. N. (2004)
      Seizures are sometimes the first manifestation of a brain tumour. They may give rise to shoulder fractures or fracture-dislocations. When bilateral, these lesions tend to be symmetrical. The patient reported here suffered ...

    • Complications Associated with Surgery for Thoracic Disc Herniation: A Systematic Review and Network Meta-Analysis 

      Brotis A.G., Tasiou A., Paterakis K., Tzerefos C., Fountas K.N. (2019)
      Background: A systematic review and network meta-analysis (Prospero ID CRD42018106936) were performed. Objective: The selection of the appropriate surgical approach for the management of thoracic disc herniation (TDH) is ...

    • Development and validation of a reversed-phase HPLC method for licarbazepine monitoring in serum of patients under oxcarbazepine treatment 

      Begas E., Tsakalof A., Dardiotis E., Vatidis G.E., Kouvaras E., Asprodini E.K. (2017)
      Licarbazepine is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders. Several HPLC methods have been developed thus far but there is lack ...

    • Effect of continuing versus stopping pre-stroke antihypertensive agents within 12 h on outcome after stroke: A subgroup analysis of the efficacy of nitric oxide in stroke (ENOS) trial 

      Woodhouse L.J., Appleton J.P., Scutt P., Everton L., Wilkinson G., Caso V., Czlonkowska A., Gommans J., Krishnan K., Laska A.C., Ntaios G., Ozturk S., Phillips S., Pocock S., Prasad K., Szatmari S., Wardlaw J.M., Sprigg N., Bath P.M., ENOS Investigators (2022)
      Background: It is not known whether to continue or temporarily stop existing antihypertensive drugs in patients with acute stroke. Methods: We performed a prospective subgroup analysis of patients enrolled into the Efficacy ...

    • Epilepsy and neurosurgery: Historical highlights 

      Karamanou M., Tsoucalas G., Themistocleous M., Giakoumettis D., Stranjalis G., Androutsos G. (2017)
      Epilepsy has been known since antiquity and trepanation has been documented as a therapeutic option. The Greek born physician Aretaeus of Cappadocia (2nd century BC) was the first to recommend trepanation for the treatment ...

    • Fahr's syndrome due to hypoparathyroidism revisited: A case of parkinsonism and a review of all published cases 

      Kalampokini S., Georgouli D., Dadouli K., Ntellas P., Ralli S., Valotassiou V., Georgoulias P., Hadjigeorgiou G.M., Dardiotis E., Xiromerisiou G. (2021)
      Introduction: Fahr's syndrome due to hypoparathyroidism refers to bilateral basal ganglia (BG) calcifications and manifests with movement disorders, seizures, cognitive and behavioral symptoms. Case presentation: We report ...

    • The frequency of central nervous system complications in the Cypriot cohort of ATTRV30M neuropathy transplanted patients 

      Dardiotis E., Andreou S., Aloizou A.-M., Panayiotou E., Siokas V., Ioannou M.N., Vounou E., Christodoulou K., Tanteles G.A., Michaelides D., Kyriakides T. (2020)
      Background: Hereditary transthyretin amyloidosis (ATTR) is a hereditary, sensorimotor and autonomic neuropathy caused by deposits of mutated transthyretin (TTR). The commonest TTR mutation is V30M (ATTRV30M) with patients ...

    • Glioblastoma Multiforme in a Patient with Celiac Disease: Management of Seizures After Gross Total Tumor Resection 

      Fotakopoulos G., Brotis A.G., Kotlia P., Fountas K. (2018)
      Background: A 55-year-old woman with a history of celiac disease presented with focal seizures and a mass lesion located at the left frontal lobe. Management of seizures in these patients is challenging. Case Description: ...

    • The greek variant in app gene: The phenotypic spectrum of app mutations 

      Kalampokini S., Georgouli D., Patrikiou E., Provatas A., Valotassiou V., Georgoulias P., Spanaki C., Hadjigeorgiou G.M., Xiromerisiou G. (2021)
      Mutations in the gene encoding amyloid precursor protein (APP) cause autosomal dominant inherited Alzheimer’s disease (AD). We present a case of a 68-year-old female who presented with epileptic seizures, neuropsychiatric ...

    • Inferior Longitudinal Fascicle and Reading: Exploring Their Relationship Through a Brain Stimulation Case Study 

      Papatzalas C., Papathanasiou I., Paschalis T., Tzerefos C., Kapsalaki E., Petsiti A., Fountas K. (2022)
      Awake brain surgery allows for maximal tumor resection, while minimizing postoperative deficits, even when the tumor is located within eloquent brain regions. In the current study, we present the case of a patient who ...

    • Inorganic substances and their uses in Nikolaos Myrepsos’ Dynameron. Recent applications in modern therapy 

      Valiakos E., Marselos M., Skaltsa H. (2021)
      Inorganic compounds have been known and used since antiquity. Dynameron is the largest Byzantine medical manuscript divided into 24 sections, in accordance with the letters of the Hellenic alphabet, which contains 2667 ...

    • Intravenous sodium valproate in status epilepticus: review and Meta-analysis 

      Liampas I., Siokas V., Brotis A., Zintzaras E., Stefanidis I., Dardiotis E. (2021)
      Objective: Status epilepticus (SE) is a common neurologic emergency. The present study constitutes a meta-analysis of published randomized control trials (RCTs) evaluating the use of intravenous sodium valproate (VPA) in ...

    • The long-term prognosis of Transient Global Amnesia: A systematic review 

      Liampas I., Raptopoulou M., Siokas V., Tsouris Z., Brotis A., Aloizou A.-M., Dastamani M., Dardiotis E. (2021)
      Transient Global Amnesia (TGA) constitutes an enigmatic amnestic condition. In view of the admittedly limited knowledge regarding the nature of TGA, we decided to systematically review existing evidence for the generally ...

    • A meta-analysis on potential modifiers of LITT efficacy for mesial temporal lobe epilepsy: Seizure-freedom seems to fade with time 

      Brotis A.G., Giannis T., Paschalis T., Kapsalaki E., Dardiotis E., Fountas K.N. (2021)
      Background: The efficacy of laser interstitial thermal therapy (LITT) in mesial temporal lobe epilepsy (MTLE) has not been clearly established yet. Objective: We conducted a meta-analysis to estimate the efficacy of LITT ...

    • Neuroimaging methods in epilepsy of temporal origin 

      Tsougos I., Kousi E., Georgoulias P., Kapsalaki E., Fountas K.N. (2019)
      Background: Temporal Lobe Epilepsy (TLE) comprises the most common form of symptomatic refractory focal epilepsy in adults. Accurate lateralization and localization of the epileptogenic focus are a significant prerequisite ...

    • Primary Sjögren’s syndrome (pSS)-related cerebellar ataxia: a systematic review and meta-analysis 

      Liampas A., Nteveros A., Parperis K., Akil M., Dardiotis E., Andreadou E., Hadjivassiliou M., Zis P. (2022)
      Background: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disorder characterized by lymphocytic infiltrates of the exocrine glands, particularly the salivary and lacrimal glands, resulting in oral and ocular ...