Πλοήγηση ανά Θέμα "molecular weight"
Αποτελέσματα 1-11 από 11
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Aqueous Solubility Enhancement for Bioassays of Insoluble Inhibitors and QSPR Analysis: A TNF-α Study
(2018)The aim of this study is to improve the aqueous solubility of a group of compounds without interfering with their bioassay as well as to create a relevant prediction model. A series of 55 potential small-molecule inhibitors ... -
Biochemical and in silico identification of the active site and the catalytic mechanism of the circadian deadenylase HESPERIN
(2022)The 24-h molecular clock is based on the stability of rhythmically expressed transcripts. The shortening of the poly(A) tail of mRNAs is often the first and rate-limiting step that determines the lifespan of a mRNA and is ... -
Chemical composition and antioxidant activity of Cichorium spinosum L. leaves in relation to developmental stage
(2018)In the present study, chemical composition and bioactivity of Cichorium spinosum leaves were examined at different growth stages for optimum harvest stage and end-use assessment. Total fresh weight and number of leaves ... -
Current status and future prospects of small–molecule protein–protein interaction (PPI) inhibitors of tumor necrosis factor (TNF) and receptor activator of NF-κB ligand (RANKL)
(2018)The overexpression of Tumor Necrosis Factor (TNF) is directly related to the development of several autoimmune diseases, such as rheumatoid and psoriatic arthritis, inflammatory bowel disease, Crohn’s disease, refractory ... -
Drug-Induced Skin Adverse Reactions: The Role of Pharmacogenomics in Their Prevention
(2018)Adverse drug reactions (ADRs) affect many patients and remain a major public health problem, as they are a common cause of morbidity and mortality. It is estimated that ADRs are responsible for about 6% of hospital admissions ... -
Human mesenchymal stem cells with enhanced telomerase activity acquire resistance against oxidative stress-induced genomic damage
(2017)Background Human mesenchymal stem cells (MSC) are important tools for several cell-based therapies. However, their use in such therapies requires in vitro expansion during which MSCs quickly reach replicative senescence. ... -
Normal menstrual cycle steroid hormones variation does not affect the blood levels of total adiponectin and its multimer forms
(2015)Objective Plasma total adiponectin reveals a sexual dimorphism indicating that gonadal steroids may be involved in its secretion and/or metabolism. However, results from previous reports are conflicting and data regarding ... -
Oscillatory pressure-driven rarefied binary gas mixture flow between parallel plates
(2021)The rarefied, oscillatory, pressure-driven binary gas mixture flow between parallel plates is computationally investigated in terms of the mixture molar fraction and molecular mass ratio of the species, in a wide range of ... -
Plasminogen glycoforms alteration and activation susceptibility associated with the missense variant p.Lys330Glu in HAE-PLG patients
(2020)[No abstract available] -
Pleural transport physiology: Insights from biological marker measurements in transudates
(2011)Aims: The aim of this study was to evaluate the physicochemical properties of the pleural mesothelial barrier and of the biological markers that facilitate or eliminate the passage of molecules through the pleura. Methods ... -
Thermochemical Transition in Low Molecular Weight Substances: The Example of the Silybin Flavonoid
(2022)Silybin is a complex organic molecule with high bioactivity, extracted from the plant Silybum. As a pharmaceutical substance, silybin’s bioactivity has drawn considerable attention, while its other properties, e.g., ...