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Πλοήγηση ανά Θέμα "mRNA expression level"

Αποτελέσματα 1-10 από 10

    • Correlation between intermediary metabolism, Hsp gene expression, and oxidative stress-related proteins in long-term thermal-stressed Mytilus galloprovincialis 

      Feidantsis K., Giantsis I.A., Vratsistas A., Makri S., Pappa A.-Z., Drosopoulou E., Anestis A., Mavridou E., Exadactylos A., Vafidis D., Michaelidis B. (2020)
      Long-term exposure of Mytilus galloprovincialis to temperatures beyond 26°C triggers mussel mortality. The present study aimed to integratively illustrate the correlation between intermediary metabolism, hsp gene expression, ...

    • Development of a novel PTD-mediated IVT-mRNA delivery platform for potential protein replacement therapy of metabolic/genetic disorders 

      Miliotou A.N., Pappas I.S., Spyroulias G., Vlachaki E., Tsiftsoglou A.S., Vizirianakis I.S., Papadopoulou L.C. (2021)
      The potential clinical applications of the powerful in vitro-transcribed (IVT)-mRNAs, to restore defective protein functions, strongly depend on their successful intracellular delivery and transient translation through the ...

    • High-Fat Diet Augments the Effect of Alcohol on Skeletal Muscle Mitochondrial Dysfunction in Mice 

      Ismaeel A., Laudato J.A., Fletcher E., Papoutsi E., Tice A., Hwa L.S., Miserlis D., Jamurtas A.Z., Steiner J., Koutakis P. (2022)
      Previous studies have shown that chronic heavy alcohol consumption and consumption of a high-fat (HF) diet can independently contribute to skeletal muscle oxidative stress and mitochondrial dysfunction, yet the concurrent ...

    • Human white-fat thermogenesis: Experimental and meta-analytic findings 

      Dinas P.C., Krase A., Nintou E., Georgakopoulos A., Granzotto M., Metaxas M., Karachaliou E., Rossato M., Vettor R., Georgoulias P., S. Mayor T., Koutsikos J., Athanasiou K., Ioannou L.G., Gkiata P., Carrillo A.E., Koutedakis Y., Metsios G.S., Jamurtas A.Z., Chatziioannou S., Flouris A.D. (2021)
      White adipose tissue (WAT) thermogenic activity may play a role in whole-body energy balance and two of its main regulators are thought to be environmental temperature (Tenv) and exercise. Low Tenv may increase uncoupling ...

    • Hypoxia-Inducible Factor-2-Altered Urothelial Carcinoma: Clinical and Genomic Features 

      Vlachostergios P.J., Tamposis I.A., Anagnostou M., Papathanassiou M., Mitrakas L., Zachos I., Thodou E., Samara M., Tzortzis V. (2022)
      Background: Hypoxia is recognized as a key feature of cancer growth and is involved in various cellular processes, including proliferation, angiogenesis, and immune surveillance. Besides hypoxia-inducible factor 1-alpha ...

    • Ketogenic therapy for Parkinson's disease: A systematic review and synthesis without meta-analysis of animal and human trials 

      Grammatikopoulou M.G., Tousinas G., Balodimou C., Anastasilakis D.A., Gkiouras K., Dardiotis E., Evangeliou A.E., Bogdanos D.P., Goulis D.G. (2022)
      Objective: The aim of the present systematic review was to assess the efficacy of ketogenic therapy in Parkinson's disease (PD), using all available data from randomized controlled trials (RCTs) on humans and animal studies ...

    • microCLIP super learning framework uncovers functional transcriptome-wide miRNA interactions 

      Paraskevopoulou M.D., Karagkouni D., Vlachos I.S., Tastsoglou S., Hatzigeorgiou A.G. (2018)
      Argonaute crosslinking and immunoprecipitation (CLIP) experiments are the most widely used high-throughput methodologies for miRNA targetome characterization. The analysis of Photoactivatable Ribonucleoside-Enhanced (PAR) ...

    • On the pathogenicity of the plasminogen K330E mutation for hereditary angioedema 

      Germenis A.E., Loules G., Zamanakou M., Psarros F., González-Quevedo T., Speletas M., Bork K., Wulff K., Steinmüller-Magin L., Brænne I., Staubach-Renz P., Witzke G., Hardt J. (2018)
      [No abstract available]

    • Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology 

      Bjornsdottir G., Stefansdottir L., Thorleifsson G., Sulem P., Norland K., Ferkingstad E., Oddsson A., Zink F., Lund S.H., Nawaz M.S., Bragi Walters G., Skuladottir A.T., Gudjonsson S.A., Einarsson G., Halldorsson G.H., Bjarnadottir V., Sveinbjornsson G., Helgadottir A., Styrkarsdottir U., Gudmundsson L.J., Pedersen O.B., Hansen T.F., Werge T., Banasik K., Troelsen A., Skou S.T., Thørner L.W., Erikstrup C., Nielsen K.R., Mikkelsen S., Andersen S., Brunak S., Burgdorf K., Hjalgrim H., Jemec G., Jennum P., Johansson P.I., Nielsen K.R., Nyegaard M., Bruun M.T., Pedersen O.B., Dinh K.M., Sørensen E., Ostrowski S., Johansson P.I., Gudbjartsson D., Stefánsson H., Þorsteinsdóttir U., Larsen M.A.H., Didriksen M., Sækmose S., Zeggini E., Hatzikotoulas K., Southam L., Gilly A., Barysenka A., van Meurs J.B.J., Boer C.G., Uitterlinden A.G., Styrkársdóttir U., Stefánsdóttir L., Jonsson H., Ingvarsson T., Esko T., Mägi R., Teder-Laving M., Ikegawa S., Terao C., Takuwa H., Meulenbelt I., Coutinho de Almeida R., Kloppenburg M., Tuerlings M., Slagboom P.E., Nelissen R.R.G.H.H., Valdes A.M., Mangino M., Tsezou A., Zengini E., Alexiadis G., Babis G.C., Cheah K.S.E., Wu T.T., Samartzis D., Cheung J.P.Y., Sham P.C., Kraft P., Kang J.H., Hveem K., Zwart J.-A., Luetge A., Skogholt A.H., Johnsen M.B., Thomas L.F., Winsvold B., Gabrielsen M.E., Lee M.T.M., Zhang Y., Lietman S.A., Shivakumar M., Smith G.D., Tobias J.H., Hartley A., Gaunt T.R., Zheng J., Wilkinson J.M., Steinberg J., Morris A.P., Jonsdottir I., Bjornsson A., Olafsson I.H., Ulfarsson E., Blondal J., Vikingsson A., Brunak S., Ostrowski S.R., Ullum H., Thorsteinsdottir U., Stefansson H., Gudbjartsson D.F., Thorgeirsson T.E., Stefansson K., DBDS Genetic Consortium, GO Consortium (2022)
      Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, ...

    • The role of the NLRP3 inflammasome and the activation of IL-1β in the pathogenesis of chronic viral hepatic inflammation 

      Molyvdas A., Georgopoulou U., Lazaridis N., Hytiroglou P., Dimitriadis A., Foka P., Vassiliadis T., Loli G., Phillipidis A., Zebekakis P., Germenis A.E., Speletas M., Germanidis G. (2018)
      Background and aims: Chronic viral hepatitis is a prevalent disease with major health implications. Its underlying pathophysiological mechanisms are not fully understood. IL-1β and the NLRP3 inflammasome involvement has ...