Πλοήγηση ανά Θέμα "low drug dose"

Ascites in a patient with episodic angio-oedema and eosinophilia: Thinking outside the box

Rigopoulou E.I., Ioannou M., Papadamou G., Dalekos G.N. (2017)

Episodic angio-oedema with eosinophilia (EAE) or Gleich's syndrome is a rare condition characterised by recurrent episodes of oedema and eosinophilia, accompanied by urticaria, fever and weight gain. The presence of ascites ...

Belimumab is a promising third-line treatment option for refractory autoimmune hepatitis

Arvaniti P., Giannoulis G., Gabeta S., Zachou K., Koukoulis G.K., Dalekos G.N. (2020)

Background & Aims: Autoimmune hepatitis (AIH) is a disease of unknown aetiology with a favourable response to immunosuppression. However, in the clinic, it appears that <50% of patients achieve complete response on standard ...

Causes and Risk Factors of Cerebral Ischemic Events in Patients with Atrial Fibrillation Treated with Non-Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention: The RENo Study

Paciaroni M., Agnelli G., Caso V., Silvestrelli G., Seiffge D.J., Engelter S., De Marchis G.M., Polymeris A., Zedde M.L., Yaghi S., Michel P., Eskandari A., Antonenko K., Sohn S.-I., Cappellari M., Tassinari T., Tassi R., Masotti L., Katsanos A.H., Giannopoulos S., Acciarresi M., Alberti A., Venti M., Mosconi M.G., Vedovati M.C., Pierini P., Giustozzi M., Lotti E.M., Ntaios G., Kargiotis O., Monaco S., Lochner P., Bandini F., Liantinioti C., Palaiodimou L., Abdul-Rahim A.H., Lees K., Mancuso M., Pantoni L., Rosa S., Bertora P., Galliazzo S., Ageno W., Toso E., Angelini F., Chiti A., Orlandi G., Denti L., Flomin Y., Marcheselli S., Mumoli N., Rimoldi A., Verrengia E., Schirinzi E., Del Sette M., Papamichalis P., Komnos A., Popovic N., Zarkov M., Rocco A., Diomedi M., Giorli E., Ciccone A., Grory B.C.M., Furie K.L., Bonetti B., Saia V., Guideri F., Acampa M., Martini G., Grifoni E., Padroni M., Karagkiozi E., Perlepe K., Makaritsis K., Mannino M., MacCarrone M., Ulivi L., Giannini N., Ferrari E., Pezzini A., Doronin B., Volodina V., Baldi A., D'Amore C., Deleu D., Corea F., Putaala J., Santalucia P., Nardi K., Risitano A., Toni D., Tsivgoulis G. (2019)

Background and Purpose-Despite treatment with oral anticoagulants, patients with nonvalvular atrial fibrillation (AF) may experience ischemic cerebrovascular events. The aims of this case-control study in patients with AF ...

Chios mastic gum: A plant-produced resin exhibiting numerous diverse pharmaceutical and biomedical prοperties

Dimas, K. S.; Pantazis, P.; Ramanujam, R. (2012)

Chios mastic gum (CMG) is a resin produced by the plant Pistacia lentiscus var. chia. CMG is used to extract the mastic gum essential oil (MGO). CMG and MGO consist of nearly 70 constituents and have demonstrated numerous ...

Combination of exercise training and dopamine agonists in patients with RLS on dialysis: A randomized, double-blind placebo-controlled study

Giannaki C.D., Sakkas G.K., Karatzaferi C., Maridaki M.D., Koutedakis Y., Hadjigeorgiou G.M., Stefanidis I. (2015)

Both exercise training and treatment with dopamine agonists (DA) have been used with success for the amelioration of uremic restless legs syndrome (RLS) symptoms. However, no data are available combining those two approaches. ...

Combinatorial usage of sumac unriped fruit extract (Rhus Coriaria) and tannic acid enhanced synergistic anti-angiogenic effect on chick chorioallantoic membrane assay

Üvez A., Kiliç Ş., Esener O.B.B., Ünder D., Saltan F.Z., Dimas K., Armutak E.I. (2021)

Rhus coriaria (sumac) naturally grows worldwide and contains many phytochemicals. Tannic acid is frequently used for treating medical conditions. The aim of this study is to determine the synergistic effects of methanolic ...

A comprehensive analysis of antigen-specific antibody responses against human cytomegalovirus in patients with systemic sclerosis

Efthymiou G., Dardiotis E., Liaskos C., Marou E., Scheper T., Meyer W., Daponte A., Daoussis D., Hadjigeorgiou G., Bogdanos D.P., Sakkas L.I. (2019)

Anti-human cytomegalovirus (HCMV) antibodies are considered triggers of systemic sclerosis (SSc), but such a hypothesis has been assessed in limited sub-dominant epitopes. Our aim was to systematically assess the potential ...

Do we overtreat mild persistent asthma?

Loukides, S.; Kostikas, K.; Bakakos, P. (2009)

Dose-Dependent Effects of Ranolazine on Reentrant Ventricular Arrhythmias Induced After Subacute Myocardial Infarction in Rabbits

Moschovidis V., Simopoulos V., Stravela S., Dipla K., Hatziefthimiou A., Stamatiou R., Aidonidis I. (2020)

Ranolazine has been found to prevent ventricular arrhythmias (VAs) during acute myocardial infarction (AMI). This study aimed to investigate its efficacy on VAs induced several days post-MI. For this purpose, 13 anesthetized ...

Early primary biliary cirrhosis: A new association with erythema nodosum of unknown origin

Dalekos, G. N.; Gatselis, N. K.; Zachou, K. (2010)

Primary biliary cirrhosis (PBC) is associated with immune-mediated dermatologic disorders. The association of PBC with erythema nodosum (EN) seems rare. We report two females (42 and 44 years old) with low-grade fever, ...

Effect of adiponectin on estradiol and progesterone secretion from human luteinized granulosa cells in vitro

Messini C.I., Vasilaki A., Korona E., Anifandis G., Katsiani E., Georgoulias P., Dafopoulos K., Garas A., Daponte A., Messinis I.E. (2021)

Ιnformation on the role of adiponectin in human ovarian steroidogenesis is limited. The present study aimed to investigate the effect of different doses of adiponectin on the secretion of estradiol and progesterone by human ...

Effectiveness and safety of intracranial events associated with the use of direct oral anticoagulants for atrial fibrillation: A systematic review and meta-analysis of 92 studies

Archontakis-Barakakis P., Li W., Kalaitzoglou D., Tzelves L., Manolopoulos A., Giannopoulos S., Giamouzis G., Giannakoulas G., Batsidis A., Palaiodimos L., Ntaios G., Lip G.Y.H., Kokkinidis D.G. (2022)

Aims: Observational studies have investigated the effectiveness and safety of direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) used in nonvalvular atrial fibrillation. We performed a systematic review ...

The effects of old, new and emerging medicines on metabolic aberrations in PCOS

Bargiota, A.; Diamanti-Kandarakis, E. (2012)

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age that is associated with significant adverse short- and long-term health consequences. Multiple metabolic aberrations, such as ...

Embolic Stroke of Undetermined Source: JACC Review Topic of the Week

Ntaios G. (2020)

The term embolic stroke of undetermined source (ESUS) was introduced in 2014 to describe patients with a nonlacunar ischemic stroke and no convincing etiology. The terms ESUS and cryptogenic stroke are not synonyms, as the ...

Epidemiology and importance of renal dysfunction in heart failure patients

Giamouzis, G.; Kalogeropoulos, A. P.; Butler, J.; Karayannis, G.; Georgiopoulou, V. V.; Skoularigis, J.; Triposkiadis, F. (2013)

Renal dysfunction (RD) is a frequent comorbid condition and a major determinant of outcomes in patients with heart failure (HF). It is likely that the etiology of RD in patients with HF is much more complex than we first ...

Evaluation of specific immune responses to BoNT/A and tetanus toxoid in patients undergoing treatment for neurologic disorders

Vlata, Z.; Tsatsakis, A.; Tzagournissakis, M.; Krambovitis, E. (2012)

Botulinum neurotoxins (BoNTs) are used in the treatment of many neurological disorders. The primary structure of BoNTs shows a high degree of homology with the tetanus neurotoxin, the toxoid of which is used as a vaccine. ...

Expert consensus on the rational clinical use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors

Achimastos A., Alexandrides T., Alexopoulos D., Athyros V., Bargiota A., Bilianou E., Chrysochoou C., Drogari E., Elisaf M., Ganotakis E., Goudevenos I., Ioannidis I., Kolovou G., Kotsis V., Lekakis I., Liberopoulos E., Melidonis A., Nikolaou V., Ntaios G., Papanas N., Pappas S., Pitsavos C., Rallidis L., Richter D., Skoumas I., Tentolouris N., Tousoulis D., Tselepis A., Tsioufis K., Tziakas D., Tziomalos K., Vardas P., Vlachopoulo C., Vlahakos D. (2016)

Two proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, evolocumab and alirocumab, have recently been approved by both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the ...

Fixed dilated pupils in Covid-19 ARDS patients under rocuronium, reversed after discontinuation

Zakynthinos G.E., Tsolaki V., Bardaka F., Makris D. (2021)

Neuromuscular Blockade Agents (NMBA) are used in the management of moderate and severe Acute Respiratory Distress Syndrome (ARDS) patients. They have never been reported to present Central Nervous System adverse reactions. ...

Human cytomegalovirus (HCMV) UL44 and UL57 specific antibody responses in anti-HCMV-positive patients with systemic sclerosis

Marou E., Liaskos C., Simopoulou T., Efthymiou G., Dardiotis E., Katsiari C., Scheper T., Meyer W., Hadjigeorgiou G., Bogdanos D.P., Sakkas L.I. (2017)

The role of human cytomegalovirus (HCMV) has been postulated as a trigger of systemic sclerosis (SSc). The aim of the study was to assess the prevalence of antibodies against HCMV UL44 and UL57 antigens not tested in the ...

Immunotherapy of systemic sclerosis

Katsiari C.G., Simopoulou T., Alexiou I., Sakkas L.I. (2018)

Systemic sclerosis (SSc) is a chronic systemic disease characterized by microvasculopathy, immune activation, and extensive collagen deposition. Microvasculopathy and immune activation occur very early in the disease ...