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Πλοήγηση ανά Θέμα "genome analysis"

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    • Ancestral Absence of Electron Transport Chains in Patescibacteria and DPANN 

      Beam J.P., Becraft E.D., Brown J.M., Schulz F., Jarett J.K., Bezuidt O., Poulton N.J., Clark K., Dunfield P.F., Ravin N.V., Spear J.R., Hedlund B.P., Kormas K.A., Sievert S.M., Elshahed M.S., Barton H.A., Stott M.B., Eisen J.A., Moser D.P., Onstott T.C., Woyke T., Stepanauskas R. (2020)
      Recent discoveries suggest that the candidate superphyla Patescibacteria and DPANN constitute a large fraction of the phylogenetic diversity of Bacteria and Archaea. Their small genomes and limited coding potential have ...

    • Association of α-synuclein Rep1 polymorphism and Parkinson's disease: Influence of Rep1 on age at onset 

      Hadjigeorgiou, G. H.; Xiromerisiou, G.; Gourbali, V.; Aggelakis, K.; Scarmeas, N.; Papadimitriou, A.; Singleton, A. (2006)
      The α-synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD; adjusted odd ratio = 3.25; 95% CI = 1.80-5.87). ...

    • COVID-19 and human reproduction: A pandemic that packs a serious punch 

      Anifandis G., Tempest H.G., Oliva R., Swanson G.M., Simopoulou M., Easley C.A., Primig M., Messini C.I., Turek P.J., Sutovsky P., Ory S.J., Krawetz S.A. (2021)
      The COVID-19 pandemic has led to a worldwide health emergency that has impacted 188 countries at last count. The rapid community transmission and relatively high mortality rates with COVID-19 in modern times are relatively ...

    • Experimental study of the potential role of salmonella enterica subsp. Diarizonae in the diarrhoeic syndrome of lambs 

      Chatzopoulos D.C., Vasileiou N.G.C., Ioannidi K.S., Katsafadou A.I., Mavrogianni V.S., Michael C.K., Katsarou E.I., Karavanis E., Papadopoulos N., Sbiraki A., Athanasiou L.V., Billinis C., Fthenakis G.C. (2021)
      The objectives of this experimental work were the evaluation of the potential role of Salmonella enterica subsp. diarizonae in diarrhoeic syndrome in lambs and the investigation of facets of the pathogenesis of the infection. ...

    • Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture 

      Chia R., Sabir M.S., Bandres-Ciga S., Saez-Atienzar S., Reynolds R.H., Gustavsson E., Walton R.L., Ahmed S., Viollet C., Ding J., Makarious M.B., Diez-Fairen M., Portley M.K., Shah Z., Abramzon Y., Hernandez D.G., Blauwendraat C., Stone D.J., Eicher J., Parkkinen L., Ansorge O., Clark L., Honig L.S., Marder K., Lemstra A., St George-Hyslop P., Londos E., Morgan K., Lashley T., Warner T.T., Jaunmuktane Z., Galasko D., Santana I., Tienari P.J., Myllykangas L., Oinas M., Cairns N.J., Morris J.C., Halliday G.M., Van Deerlin V.M., Trojanowski J.Q., Grassano M., Calvo A., Mora G., Canosa A., Floris G., Bohannan R.C., Brett F., Gan-Or Z., Geiger J.T., Moore A., May P., Krüger R., Goldstein D.S., Lopez G., Tayebi N., Sidransky E., Sotis A.R., Sukumar G., Alba C., Lott N., Martinez E.M.G., Tuck M., Singh J., Bacikova D., Zhang X., Hupalo D.N., Adeleye A., Wilkerson M.D., Pollard H.B., Norcliffe-Kaufmann L., Palma J.-A., Kaufmann H., Shakkottai V.G., Perkins M., Newell K.L., Gasser T., Schulte C., Landi F., Salvi E., Cusi D., Masliah E., Kim R.C., Caraway C.A., Monuki E.S., Brunetti M., Dawson T.M., Rosenthal L.S., Albert M.S., Pletnikova O., Troncoso J.C., Flanagan M.E., Mao Q., Bigio E.H., Rodríguez-Rodríguez E., Infante J., Lage C., González-Aramburu I., Sanchez-Juan P., Ghetti B., Keith J., Black S.E., Masellis M., Rogaeva E., Duyckaerts C., Brice A., Lesage S., Xiromerisiou G., Barrett M.J., Tilley B.S., Gentleman S., Logroscino G., Serrano G.E., Beach T.G., McKeith I.G., Thomas A.J., Attems J., Morris C.M., Palmer L., Love S., Troakes C., Al-Sarraj S., Hodges A.K., Aarsland D., Klein G., Kaiser S.M., Woltjer R., Pastor P., Bekris L.M., Leverenz J.B., Besser L.M., Kuzma A., Renton A.E., Goate A., Bennett D.A., Scherzer C.R., Morris H.R., Ferrari R., Albani D., Pickering-Brown S., Faber K., Kukull W.A., Morenas-Rodriguez E., Lleó A., Fortea J., Alcolea D., Clarimon J., Nalls M.A., Ferrucci L., Resnick S.M., Tanaka T., Foroud T.M., Graff-Radford N.R., Wszolek Z.K., Ferman T., Boeve B.F., Hardy J.A., Topol E.J., Torkamani A., Singleton A.B., Ryten M., Dickson D.W., Chiò A., Ross O.A., Gibbs J.R., Dalgard C.L., Traynor B.J., Scholz S.W., The American Genome Center (2021)
      The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this ...

    • Identification of Chromosomal Regions Linked to Autism-Spectrum Disorders: A Meta-Analysis of Genome-Wide Linkage Scans 

      Mpoulimari I., Zintzaras E. (2022)
      Background: Autism spectrum disorder (ASD) is a clinically and genetically heterogeneous group of pervasive neurodevelopmental disorders with a strong hereditary component. Although, genome-wide linkage scans (GWLS) and ...

    • Interspecies transmission of Rotaviruses among ruminants, dogs and humans: Current facts and remarks 

      Valiakos G., Chatzopoulos D.C., Tsokana C.N. (2017)
      Rotaviruses are considered to be a major cause of diarrhoea to humans as well as a wide variety of animals and may cause serious economic losses in livestock animals, especially swine and ruminants. This fact, along with ...

    • Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study 

      Elbaz, A.; Nelson, L. M.; Payami, H.; Ioannidis, J. P.; Fiske, B. K.; Annesi, G.; Carmine Belin, A.; Factor, S. A.; Ferrarese, C.; Hadjigeorgiou, G. M.; Higgins, D. S.; Kawakami, H.; Krüger, R.; Marder, K. S.; Mayeux, R. P.; Mellick, G. D.; Nutt, J. G.; Ritz, B.; Samii, A.; Tanner, C. M.; Van Broeckhoven, C.; Van Den Eeden, S. K.; Wirdefeldt, K.; Zabetian, C. P.; Dehem, M.; Montimurro, J. S.; Southwick, A.; Myers, R. M.; Trikalinos, T. A. (2006)
      Background: A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale replication studies were largely non-confirmatory, but a ...

    • Patient with prostatic adenocarcinoma with plasmacytoid features and an aberrant immunohistochemical phenotype diagnosed by biopsy and a mini-review of plasmacytoid features in the genitourinary system: A case report 

      Zacharouli K., Vageli D.P., Koukoulis G.K., Ioannou M. (2022)
      Prostate cancer is one of the most commonly diagnosed malignancies in men. Most of these tumors are adenocarcinomas. Plasmacytoid is a rare variant of adenocarcinoma described by previous studies in the genitourinary system ...

    • Prediction of cell wall sorting signals in gram-positive bacteria with a hidden markov model: Application to complete genomes 

      Litou, Z. I.; Bagos, P. G.; Tsirigos, K. D.; Liakopoulos, T. D.; Hamodrakas, S. J. (2008)
      Surface proteins in Gram-positive bacteria are frequently implicated in virulence. We have focused on a group of extracellular cell wall-attached proteins (CWPs), containing an LPXTG motif for cleavage and covalent coupling ...

    • Proteomics challenging medicine 

      Germenis, A. E.; Patrikidou, A. (2005)
      The study of the genome dictated that the whole is more than the sum of its parts; genes do not function independently but in networks. The impact of this understanding was explosive. It acknowledged the concept that this ...

    • Suggestive evidence for linkage for restless legs syndrome on chromosome 19p13 

      Kemlink, D.; Plazzi, G.; Vetrugno, R.; Provini, F.; Polo, O.; Stiasny-Kolster, K.; Oertel, W.; Nevsimalova, S.; Sonka, K.; Högl, B.; Frauscher, B.; Hadjigeorgiou, G. M.; Pramstaller, P. P.; Lichtner, P.; Meitinger, T.; Müller-Myshok, B.; Winkelmann, J.; Montagna, P. (2008)
      Five loci for restless legs syndrome (RLS) on chromosomes 12q, 14q, 9p, 2q, and 20p (RLS1-RLS5) have been mapped in RLS families, with a recessive in the first and autosomal-dominant mode of inheritance in the latter cases. ...

    • Systematic review of pcr proof of parvovirus b19 genomes in endomyocardial biopsies of patients presenting with myocarditis or dilated cardiomyopathy 

      Rigopoulos A.G., Klutt B., Matiakis M., Apostolou A., Mavrogeni S., Noutsias M. (2019)
      Background: Diverse viral infections have been associated with myocarditis (MC) and dilated cardiomyopathy (DCM). In this meta-analysis, we summarize the published results on the association of parvovirus B19 (B19V) genomes ...

    • The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species 

      Papanicolaou A., Schetelig M.F., Arensburger P., Atkinson P.W., Benoit J.B., Bourtzis K., Castañera P., Cavanaugh J.P., Chao H., Childers C., Curril I., Dinh H., Doddapaneni H.V., Dolan A., Dugan S., Friedrich M., Gasperi G., Geib S., Georgakilas G., Gibbs R.A., Giers S.D., Gomulski L.M., González-Guzmán M., Guillem-Amat A., Han Y., Hatzigeorgiou A.G., Hernández-Crespo P., Hughes D.S.T., Jones J.W., Karagkouni D., Koskinioti P., Lee S.L., Malacrida A.R., Manni M., Mathiopoulos K., Meccariello A., Murali S.C., Murphy T.D., Muzny D.M., Oberhofer G., Ortego F., Paraskevopoulou M.D., Poelchau M., Qu J., Reczko M., Robertson H.M., Rosendale A.J., Rosselot A.E., Saccone G., Salvemini M., Savini G., Schreiner P., Scolari F., Siciliano P., Sim S.B., Tsiamis G., Ureña E., Vlachos I.S., Werren J.H., Wimmer E.A., Worley K.C., Zacharopoulou A., Richards S., Handler A.M. (2016)
      Background: The Mediterranean fruit fly (medfly), Ceratitis capitata, is a major destructive insect pest due to its broad host range, which includes hundreds of fruits and vegetables. It exhibits a unique ability to invade ...