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Πλοήγηση ανά Θέμα "genetic model"

Αποτελέσματα 1-9 από 9

    • ADORA2A rS5760423 and CYP1A2 rs762551 polymorphisms as risk factors for parkinson’s disease 

      Siokas V., Aloizou A.-M., Tsouris Z., Liampas I., Liakos P., Calina D., Docea A.O., Tsatsakis A., Bogdanos D.P., Hadjigeorgiou G.M., Dardiotis E. (2021)
      Background: Parkinson’s disease (PD) is the second commonest neurodegenerative disease. The genetic basis of PD is indisputable. Both ADORA2A rs5760423 and CYP1A2 rs762551 have been linked to PD, to some extent, but the ...

    • Analysis of SOD2 rs4880 Genetic Variant in Patients with Alzheimer’s Disease 

      Siokas V., Stamati P., Pateraki G., Liampas I., Aloizou A.-M., Tsirelis D., Nousia A., Sgantzos M., Nasios G., Bogdanos D.P., Dardiotis E. (2022)
      A few gene loci that contribute to Alzheimer’s Disease (AD) onset have been identified. Few studies have been published about the relationship between SOD2 rs4880 single nucleotide variant and AD, revealing inconsistent ...

    • Does the CD33 rs3865444 Polymorphism Confer Susceptibility to Alzheimer’s Disease? 

      Siokas V., Aslanidou P., Aloizou A.-M., Peristeri E., Stamati P., Liampas I., Arseniou S., Drakoulis N., Aschner M., Tsatsakis A., Mitsias P.D., Bogdanos D.P., Hadjigeorgiou G.M., Dardiotis E. (2020)
      Alzheimer’s disease (AD) is a complex genetic disorder. To date, published data have reported conflicting results on the role of CD33 rs3865444 polymorphism in AD. The present study aimed at evaluating the effect of rs3865444 ...

    • Lack of an association between SCFD1 rs10139154 polymorphism and amyotrophic lateral sclerosis 

      Siokas V., Aloizou A.-M., Liampas I., Bakirtzis C., Nasios G., Paterakis K., Sgantzos M., Bogdanos D.P., Spandidos D.A., Tsatsakis A., Mitsias P.D., Dardiotis E. (2022)
      Amyotrophic lateral sclerosis (AL S) is a progressive neurodegenerative disease. Through a genome-wide association study (GWAS), the Sec1 family domain-containing protein 1 (SCFD1) rs10139154 variant at 14q12 has emerged ...

    • Multiple sclerosis: Shall we target cd33? 

      Siokas V., Tsouris Z., Aloizou A.-M., Bakirtzis C., Liampas I., Koutsis G., Anagnostouli M., Bogdanos D.P., Grigoriadis N., Hadjigeorgiou G.M., Dardiotis E. (2020)
      Background: Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS). Myeloid lineage cells (microglia and macrophages) may participate in the pathogenic mechanisms leading to MS. CD33 is a transmembrane ...

    • Multivariate methods for meta-analysis of genetic association studies 

      Dimou N.L., Pantavou K.G., Braliou G.G., Bagos P.G. (2018)
      Multivariate meta-analysis of genetic association studies and genome-wide association studies has received a remarkable attention as it improves the precision of the analysis. Here, we review, summarize and present in a ...

    • The role of hypoxia-inducible factor-2 alpha in angiogenesis 

      Befani C., Liakos P. (2018)
      Angiogenesis is a key enabling feature of mammalian embryonic development and tumor progression, which provides oxygen and nutrients that are required for vessel growth and tumor cell growth, respectively. Hypoxia is a ...

    • A systematic review and meta-analysis of pharmacogenetic studies in patients with chronic kidney disease 

      Tziastoudi M., Pissas G., Raptis G., Cholevas C., Eleftheriadis T., Dounousi E., Stefanidis I., Theoharides T.C. (2021)
      Chronic kidney disease (CKD) is an important global public health problem due to its high prevalence and morbidity. Although the treatment of nephrology patients has changed considerably, ineffectiveness and side effects ...

    • Variants of the elastin (ELN) gene and susceptibility to intracranial aneurysm: a synthesis of genetic association studies using a genetic model-free approach 

      Paterakis K., Koutsias S., Doxani C., Xanthopoulou P., Kokkali C., Mpoulimari I., Tziastoudi M., Karampelas I., Dardiotis E., Hadjigeorgiou G., Brotis A.G., Zintzaras E. (2017)
      Background: The presence of an intracranial aneurysm (IA) is thought to have a genetic origin. The genetic association studies (GAS) that investigated the association between IA and elastin gene (ELN) variants have produced ...