• Cadherin and Wnt signaling pathways as key regulators in diabetic nephropathy 

      Tziastoudi M., Tsezou A., Stefanidis I. (2021)
      Aim A recent meta-analysis of genome-wide linkage studies (GWLS) has identified multiple genetic regions suggestive of linkage with DN harboring hundreds of genes. Moving this number of genetic loci forward into biological ...
    • CD8+ PD-1+ T-cells and PD-L1+ circulating tumor cells in chemotherapy-naïve non-small cell lung cancer: towards their clinical relevance? 

      Kotsakis A., Kallergi G., Aggouraki D., Lyristi Z., Koinis F., Lagoudaki E., Koutsopoulos A., Georgoulias V., Vetsika E.-K. (2019)
      Background: Since tumor cells may escape from immune surveillance through the programmed cell death 1 (PD-1)/programmed death ligand (PD-L)1 axis, this study was designed in order to evaluate whether there is a correlation ...
    • Circulating suPAR associates with severity and in-hospital progression of COVID-19 

      Chalkias A., Skoulakis A., Papagiannakis N., Laou E., Tourlakopoulos K., Pagonis A., Michou A., Ntalarizou N., Mermiri M., Ragias D., Bernal-Morell E., Cebreiros López I., García de Guadiana-Romualdo L., Eugen-Olsen J., Gourgoulianis K., Pantazopoulos I., Chalkias A., Skoulakis A., Laou E., Michou A., Ntalarizou N., Mermiri M., Ragias D., Tourlakopoulos K., Pagonis A., Gourgoulianis K., Pantazopoulos I., Papagiannakis N., Kampolis C., García de Guadiana-Romualdo L., Albaladejo-Otón M.D., Rodríguez Mulero M.D., Galindo Martínez M., Hernández Olivo M., Campos Rodríguez V., Cebreiros López I., Arnaldos Carrillo M., Noguera Velasco J.A., Pascual Figal D.A., Bernal-Morell E., Alcaraz García A., Alcaraz García M.J., Martínez Martínez M., Esteban-Torrella P., Sancho-Rodríguez N., Eugen-Olsen J., for the SPARCOL Investigators (2022)
      Background: COVID-19 disease progression is characterized by hyperinflammation and risk stratification may aid in early aggressive treatment and advanced planning. The aim of this study was to assess whether suPAR and other ...
    • Effect of storage time on the urine protein: creatinine ratio in alkaline ovine urine 

      Athanasiou L.V., Katsoulos P.D., Spanou V.M., Pazarakioti A.T., Katsogiannou E.G., Iliadi I., Baka R., Polizopoulou Z.S. (2021)
      The urine protein:creatinine (UPC) ratio is considered the reference method to assess proteinuria. Its diagnostic value in ovine medicine needs further elucidation. In population monitoring and/or for research purposes, ...
    • Evidence for Cardiorenal Protection with SGLT-2 Inhibitors and GLP-1 Receptor Agonists in Patients with Diabetic Kidney Disease 

      Georgianos P.I., Vaios V., Roumeliotis S., Leivaditis K., Eleftheriadis T., Liakopoulos V. (2022)
      For almost two decades, the management of patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) was based on the optimal glycemic and blood pressure control as well as on the adequate blockade of ...
    • Fixed dilated pupils in Covid-19 ARDS patients under rocuronium, reversed after discontinuation 

      Zakynthinos G.E., Tsolaki V., Bardaka F., Makris D. (2021)
      Neuromuscular Blockade Agents (NMBA) are used in the management of moderate and severe Acute Respiratory Distress Syndrome (ARDS) patients. They have never been reported to present Central Nervous System adverse reactions. ...
    • Incidence, risk factors and validation of the RABBIT score for serious infections in a cohort of 1557 patients with rheumatoid arthritis 

      Thomas K., Lazarini A., Kaltsonoudis E., Voulgari P.V., Drosos A.A., Repa A., Sali A.M.I., Sidiropoulos P., Tsatsani P., Gazi S., Evangelia A., Boki K.A., Katsimbri P., Boumpas D., Fragkiadaki K., Tektonidou M.G., Sfikakis P.P., Karagianni K., Sakkas L.I., Grika E.P., Vlachoyiannopoulos P.G., Evangelatos G., Iliopoulos A., Dimitroulas T., Garyfallos A., Melissaropoulos K., Georgiou P., Areti M., Georganas C., Vounotrypidis P., Georgiopoulos G., Kitas G.D., Vassilopoulos D. (2021)
      Objectives: Predicting serious infections (SI) in patients with rheumatoid arthritis (RA) is crucial for the implementation of appropriate preventive measures. Here we aimed to identify risk factors for SI and to validate ...
    • Intravenous Thrombolysis in Patients With Ischemic Stroke Aged ≥90 Years: A Cohort Study From the TRISP Collaboration 

      Altersberger V.L., Rusche N., Martinez-Majander N., Hametner C., Scheitz J.F., Henon H., Dell'acqua M.L., Strambo D., Stolp J., Heldner M.R., Grisendi I., Jovanovic D.R., Bejot Y., Pezzini A., Leker R.R., Kägi G., Wegener S., Cereda C.W., Lindgren E., Ntaios G., Piot I., Polymeris A.A., Lyrer P.A., Räty S., Sibolt G., Tiainen M., Heyse M., Erdur H., Kaaouana O., Padjen V., Zedde M., Arnold M., Nederkoorn P.J., Michel P., Bigliardi G., Zini A., Cordonnier C., Nolte C.H., Ringleb P.A., Curtze S., Engelter S.T., Gensicke H., for the Thrombolysis in Stroke Patients (TRISP) Collaborators (2022)
      Background: The probability to receive intravenous thrombolysis (IVT) for treatment of acute ischemic stroke declines with increasing age and is consequently the lowest in very elderly patients. Safety concerns likely ...
    • Mechanisms for cardiorenal protection of sglt-2 inhibitors 

      Georgianos P.I., Vaios V., Dounousi E., Salmas M., Eleftheriadis T., Liakopoulos V. (2021)
      Despite optimal treatment of diabetic kidney disease (DKD) with adequate blood pressure control and agents blocking the renin-angiotensin-system (RAS), the residual cardiorenal risk of these patients remains substantially ...
    • Pulse wave velocity assessment for cardiovascular risk prognostication in eskd: Weighting recent evidence 

      Georgianos P.I., Vaios V., Eleftheriadis T., Zebekakis P.E., Liakopoulos V. (2021)
      Background: Among patients with end-stage kidney disease (ESKD), arterial stiffness is considered as a powerful predictor of cardiovascular (CV) morbidity and mortality. However, the relevance of aortic pulse wave velocity ...
    • Quiz: Nine Years of Persistent, Disabling Foot Pain in a Kidney Transplant Recipient 

      Eleftheriadis T., Rountas C., Vlassis S., Karagiorgas G., Pissas G., Liakopoulos V., Stefanidis I. (2017)
      [No abstract available]
    • Renal function and risk stratification of patients with embolic stroke of undetermined source 

      Ntaios G., Lip G.Y.H., Lambrou D., Michel P., Perlepe K., Eskandari A., Nannoni S., Sirimarco G., Strambo D., Vemmos K., Koroboki E., Manios E., Vemmou A., Rodríguez-Campello A., Cuadrado-Godia E., Roquer J., Arnao V., Caso V., Paciaroni M., Diez-Tejedor E., Fuentes B., Pardo J.R., Arauz A., Ameriso S.F., Pertierra L., Gómez-Schneider M., Hawkes M.A., Bandini F., Cano B.C., Mohedano A.M.I., Pastor A.G., Gil-Núñez A., Putaala J., Tatlisumak T., Barboza M.A., Karagkiozi E., Makaritsis K., Papavasileiou V. (2018)
      Background and Purpose-We aimed to assess if renal function can aid in risk stratification for ischemic stroke or transient ischemic attack (TIA) recurrence and death in patients with embolic stroke of undetermined source ...
    • Soluble urokinase receptor (SuPAR) in COVID-19-Related AKI 

      Azam T.U., Shadid H.R., Blakely P., O'Hayer P., Berlin H., Pan M., Zhao P., Zhao L., Pennathur S., Pop-Busui R., Altintas I., Tingleff J., Stauning M.A., Andersen O., Adami M.-E., Solomonidi N., Tsilika M., Tober-Lau P., Arnaoutoglou E., Keitel V., Tacke F., Chalkias A., Loosen S.H., Giamarellos-Bourboulis E.J., Eugen-Olsen J., Reiser J., Hayek S.S., Hayek S.S., Blakely P., Berlin H., Azam T.U., Shadid H., Pan M., O'Hayer P., Meloche C., Feroze R., Padalia K.J., Anderson E., Perry D., Bitar A., Kaakati R., Zhao L., Zhao P., Eugen-Olsen J., Altintas I., Tingleff J., Stauning M., Houlind M.B., Lindstrøm M.B., Andersen O., Gamst-Jensen H., Rasmussen L.J.H., Rasmussen C., Nehlin J.O., Kallemose T., Parvaiz I., Adami M.-E., Solomonidi N., Tsilika M., Saridaki M., Lekakis V., Loosen S., Luedde T., Keitel V., Arnaoutoglou E., Pantazopoulos I., Laou E., Kolonia K., Skoulakis A., Tacke F., Tober-Lau P., Mohr R., Kurth F., Sander L.E., Jochum C., International Study of Inflammation in COVID-19 (2020)
      Background AKI commonly occurs in patients with coronavirus disease 2019 (COVID-19). Its pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the intersection between inflammation, immunity, ...