Πλοήγηση ανά Θέμα "drug metabolism"
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The absorption and metabolism of a single L-menthol oral versus skin administration: Effects on thermogenesis and metabolic rate
(2015)We investigated the absorption and metabolism pharmacokinetics of a single L-menthol oral versus skin administration and the effects on human thermogenesis and metabolic rate. Twenty healthy adults were randomly distributed ... -
Antimicrobial activity of bee-collected pollen and beebread: State of the art and future perspectives
(2020)Bee-collected pollen (BCP) is a well-known functional food. Honey bees process the collected pollen and store it in the hive, inside the comb cells. The processed pollen is called beebread or ambrosia and it is the main ... -
Caffeine metabolism in liver cirrhosis
(2005)Caffeine is metabolized primarily by CYP1A2. Several methods have been developed for the in vivo assessment of CYP1A2 activity using caffeine as a probe drug (2). These methods include the determination of caffeine clearance ... -
Dopexamine after heart surgery: An uncommonly used, though useful inotropic agent
(2010)A great variety of inotropic agents with different effects on peripheral vascular resistance have been employed in the endeavor to treat heart failure after cardiac surgery. Epinephrine, norepinephrine, dopamine and ... -
Genetic polymorphism of canine cytochrome P450 2D25 gene
(2004)Human CYP2D6 is involved in the metabolism of a number of drugs including neuroleptics, tricyclic antidepressants, β-adrenoreceptors antagonists and antiarrhythmic drugs. The corresponding canine CYP2D15 have shown similar ... -
Immune-Related Gene Polymorphisms and Pharmacogenetic Studies in Nephrology
(2021)A large subgroup of patients with chronic kidney disease still encounter serious adverse effects and lack of responsiveness to medications, possibly because of the interindividual genetic variability in genes involved in ... -
Intensity of Humoral Immune Responses, Adverse Reactions, and Post-Vaccination Morbidity after Adenovirus Vector-Based and mRNA Anti-COVID-19 Vaccines
(2022)The aim of the study was to compare mRNA vaccine BNT162b2 with adenovirus vector- based vaccines in terms of presence of adverse reactions, immunogenicity, and protection against COVID-19. A total of 270 individuals were ... -
The metabolism of imidacloprid by aldehyde oxidase contributes to its clastogenic effect in New Zealand rabbits
(2018)Imidacloprid (IMI) is a systemic, chloro-nicotinyl insecticide classified in Regulation N° 1272/2008 of the European Commision as “harmful if swallowed and very toxic to aquatic life, with long-lasting effects”. IMI is ... -
Skeletal muscle relaxants in anaesthesiology
(1999)During the 16th century, European explorers found that the Indians along the Amazon and Orinoco Rivers were using an arrow poison, named curare, that produced death by skeletal paralysis. Curare is one of several different ... -
Targeted and global pharmacometabolomics in everolimus-based immunosuppression: association of co-medication and lysophosphatidylcholines with dose requirement
(2018)Introduction: The immunosuppressive therapy with everolimus (ERL) after heart transplantation is characterized by a narrow therapeutic window and a substantial variability in dose requirement. Factors explaining this ... -
Upadacitinib tartrate in rheumatoid arthritis
(2020)does not achieve low disease activity or remission despite the use of conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) and/or biological DMARDs (bDMARDs). The Janus kinase (JAK) inhibitors are the ...