• Acute phase markers for the differentiation of infectious and malignant pleural effusions 

      Kiropoulos, T. S.; Kostikas, K.; Oikonomidi, S.; Tsilioni, I.; Nikoulis, D.; Germenis, A.; Gourgoulianis, K. I. (2007)
      Acute-phase markers, such as C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α), have been studied in inflammatory and malignant disorders. We examined the diagnostic value of these ...
    • Apolipoprotein ϵ4 allele is associated with frailty syndrome: Results from the hellenic longitudinal investigation of ageing and diet study 

      Mourtzi N., Ntanasi E., Yannakoulia M., Kosmidis M., Anastasiou C., Dardiotis E., Hadjigeorgiou G., Sakka P., Scarmeas N. (2019)
      Apolipoprotein (APOE) ϵ4 allele has been associated with a number of age-related diseases but previous studies failed to identify any link with Frailty syndrome. The aim of the present study is to investigate the association ...
    • Atrial Cardiopathy and Likely Pathogenic Patent Foramen Ovale in Embolic Stroke of Undetermined Source 

      Leventis I.A., Sagris D., Strambo D., Perlepe K., Sirimarco G., Nannoni S., Korompoki E., Manios E., Makaritsis K., Vemmos K., Michel P., Ntaios G. (2021)
      Background  Atrial cardiopathy and likely pathogenic patent foramen ovale (PFO) are two potential embolic sources in patients with embolic stroke of undetermined source (ESUS). The relationship between these two mechanisms ...
    • Atrial Fibrillation and Dementia: A Report From the AF-SCREEN International Collaboration 

      Rivard L., Friberg L., Conen D., Healey J.S., Berge T., Boriani G., Brandes A., Calkins H., Camm A.J., Yee Chen L., Lluis Clua Espuny J., Collins R., Connolly S., Dagres N., Elkind M.S.V., Engdahl J., Field T.S., Gersh B.J., Glotzer T.V., Hankey G.J., Harbison J.A., Georg Haeusler K., Hills M.T., Johnson L.S.B., Joung B., Khairy P., Kirchhof P., Krieger D., Lip G.Y.H., Løchen M.-L., Madhavan M., Mairesse G.H., Montaner J., Ntaios G., Quinn T.J., Rienstra M., Rosenqvist M., Sandhu R.K., Smyth B., Schnabel R.B., Stavrakis S., Themistoclakis S., Van Gelder I.C., Wang J.-G., Freedman B. (2022)
      Growing evidence suggests a consistent association between atrial fibrillation (AF) and cognitive impairment and dementia that is independent of clinical stroke. This report from the AF-SCREEN International Collaboration ...
    • Causes and Risk Factors of Cerebral Ischemic Events in Patients with Atrial Fibrillation Treated with Non-Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention: The RENo Study 

      Paciaroni M., Agnelli G., Caso V., Silvestrelli G., Seiffge D.J., Engelter S., De Marchis G.M., Polymeris A., Zedde M.L., Yaghi S., Michel P., Eskandari A., Antonenko K., Sohn S.-I., Cappellari M., Tassinari T., Tassi R., Masotti L., Katsanos A.H., Giannopoulos S., Acciarresi M., Alberti A., Venti M., Mosconi M.G., Vedovati M.C., Pierini P., Giustozzi M., Lotti E.M., Ntaios G., Kargiotis O., Monaco S., Lochner P., Bandini F., Liantinioti C., Palaiodimou L., Abdul-Rahim A.H., Lees K., Mancuso M., Pantoni L., Rosa S., Bertora P., Galliazzo S., Ageno W., Toso E., Angelini F., Chiti A., Orlandi G., Denti L., Flomin Y., Marcheselli S., Mumoli N., Rimoldi A., Verrengia E., Schirinzi E., Del Sette M., Papamichalis P., Komnos A., Popovic N., Zarkov M., Rocco A., Diomedi M., Giorli E., Ciccone A., Grory B.C.M., Furie K.L., Bonetti B., Saia V., Guideri F., Acampa M., Martini G., Grifoni E., Padroni M., Karagkiozi E., Perlepe K., Makaritsis K., Mannino M., MacCarrone M., Ulivi L., Giannini N., Ferrari E., Pezzini A., Doronin B., Volodina V., Baldi A., D'Amore C., Deleu D., Corea F., Putaala J., Santalucia P., Nardi K., Risitano A., Toni D., Tsivgoulis G. (2019)
      Background and Purpose-Despite treatment with oral anticoagulants, patients with nonvalvular atrial fibrillation (AF) may experience ischemic cerebrovascular events. The aims of this case-control study in patients with AF ...
    • Comparative safety and efficacy of paracetamol versus non-steroidal anti-inflammatory agents in neonates with patent ductus arteriosus: A systematic review and meta-analysis of randomized controlled trials 

      Katsaras D.N., Katsaras G.N., Chatziravdeli V.I., Papavasileiou G.N., Touloupaki M., Mitsiakos G., Doxani C., Stefanidis I., Dardiotis E. (2022)
      Aim: Ibuprofen and indomethacin are the preferred drug treatment for patent ductus arteriosus (PDA) in preterm neonates. The comparative safety and efficacy of paracetamol as an alternative has not yet been well established. ...
    • D-dimer as a diagnostic tool for canine thromboembolic disorders [Τα Δ-διμερή ως διαγνωστικό μέσο θρομβοεμβολικών διαταραχών στο σκύλο] 

      Giannoulopoulos G.D., Athanasiou L.V., Polizopoulou Z.S. (2017)
      D-dimers are small protein fragments present in the blood after a blood clot is degraded by plasmin. During the fibrin(ogen) degradation, a number of products are produced called fibrin(ogen) degradation products (FDPs). ...
    • Epidemiology of Hypertension among Patients on Peritoneal Dialysis Using Standardized Office and Ambulatory Blood Pressure Recordings 

      Vareta G., Georgianos P.I., Vaios V., Sgouropoulou V., Roumeliotis S., Georgoulidou A., Dounousi E., Eleftheriadis T., Papagianni A., Balaskas E.V., Zebekakis P.E., Liakopoulos V. (2022)
      Introduction: Prior studies conducted in peritoneal dialysis (PD) patients in the late 1990s provided considerably variable estimates of the prevalence and control of hypertension. The present study aimed to investigate ...
    • Hyaluronic acid levels are increased in complicated parapneumonic pleural effusions 

      Zaga, T.; Makris, D.; Tsilioni, I.; Kiropoulos, T.; Oikonomidi, S.; Damianos, A.; Gourgoulianis, K. I. (2011)
      Background and Aim. Hyaluronic acid (HA) is a component of extracellular matrix and may play a role in the pleural inflammation which is implicated in parapneumonic effusions.The aim of the current study was to investigate ...
    • Measurement of Midregional Pro-Atrial Natriuretic Peptide to Discover Atrial Fibrillation in Patients With Ischemic Stroke 

      Schweizer J., Arnold M., König I.R., Bicvic A., Westphal L.P., Schütz V., Inauen C., Scherrer N., Luft A., Galovic M., Ferreira Atuesta C., Pokorny T., Arnold M., Fischer U., Bonati L.H., De Marchis G.M., Kahles T., Nedeltchev K., Cereda C.W., Kägi G., Bustamante A., Montaner J., Ntaios G., Sagris D., Foerch C., Spanaus K., von Eckardstein A., Katan M. (2022)
      Background: Midregional pro-atrial natriuretic peptide (MR-proANP) is a promising biomarker to differentiate the underlying etiology of acute ischemic stroke (AIS). Objectives: This study aimed to determine the role of ...
    • A Randomized, Placebo-Controlled Study of Romosozumab for the Treatment of Hip Fractures 

      Schemitsch E.H., Miclau T., Karachalios T., Nowak L.L., Sancheti P., Poolman R.W., Caminis J., Daizadeh N., Dent-Acosta R.E., Egbuna O., Chines A., Maddox J., Grauer A., Bhandari M. (2020)
      Background:Romosozumab is a bone-forming antibody that increases bone formation and decreases bone resorption. We conducted a double-blinded, randomized, phase-2, dose-finding trial to evaluate the effect of romosozumab ...
    • Risk Stratification for Recurrence and Mortality in Embolic Stroke of Undetermined Source 

      Ntaios G., Vemmos K., Lip G.Y.H., Koroboki E., Manios E., Vemmou A., Rodríguez-Campello A., Cuadrado-Godia E., Giralt-Steinhauer E., Arnao V., Caso V., Paciaroni M., Diez-Tejedor E., Fuentes B., Pérez Lucas J., Arauz A., Ameriso S.F., Hawkes M.A., Pertierra L., Gómez-Schneider M., Bandini F., Chavarria Cano B., Iglesias Mohedano A.M., García Pastor A., Gil-Núñez A., Putaala J., Tatlisumak T., Barboza M.A., Athanasakis G., Makaritsis K., Papavasileiou V. (2016)
      Background and Purpose - The risk of stroke recurrence in patients with Embolic Stroke of Undetermined Source (ESUS) is high, and the optimal antithrombotic strategy for secondary prevention is unclear. We investigated ...
    • Sestrin-2 is significantly increased in malignant pleural effusions due to lung cancer and is potentially secreted by pleural mesothelial cells 

      Tsilioni I., Filippidis A.S., Kerenidi T., Budanov A.V., Zarogiannis S.G., Gourgoulianis K.I. (2016)
      Objectives: Sestrin-2 (Sesn2) belongs to a family of highly conserved antioxidant proteins that were discovered as p53-inducible proteins and inhibits cell growth and proliferation. Our aim was to assess the levels of Sesn2 ...
    • Soluble urokinase receptor (SuPAR) in COVID-19-Related AKI 

      Azam T.U., Shadid H.R., Blakely P., O'Hayer P., Berlin H., Pan M., Zhao P., Zhao L., Pennathur S., Pop-Busui R., Altintas I., Tingleff J., Stauning M.A., Andersen O., Adami M.-E., Solomonidi N., Tsilika M., Tober-Lau P., Arnaoutoglou E., Keitel V., Tacke F., Chalkias A., Loosen S.H., Giamarellos-Bourboulis E.J., Eugen-Olsen J., Reiser J., Hayek S.S., Hayek S.S., Blakely P., Berlin H., Azam T.U., Shadid H., Pan M., O'Hayer P., Meloche C., Feroze R., Padalia K.J., Anderson E., Perry D., Bitar A., Kaakati R., Zhao L., Zhao P., Eugen-Olsen J., Altintas I., Tingleff J., Stauning M., Houlind M.B., Lindstrøm M.B., Andersen O., Gamst-Jensen H., Rasmussen L.J.H., Rasmussen C., Nehlin J.O., Kallemose T., Parvaiz I., Adami M.-E., Solomonidi N., Tsilika M., Saridaki M., Lekakis V., Loosen S., Luedde T., Keitel V., Arnaoutoglou E., Pantazopoulos I., Laou E., Kolonia K., Skoulakis A., Tacke F., Tober-Lau P., Mohr R., Kurth F., Sander L.E., Jochum C., International Study of Inflammation in COVID-19 (2020)
      Background AKI commonly occurs in patients with coronavirus disease 2019 (COVID-19). Its pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the intersection between inflammation, immunity, ...
    • What is considered cardiotoxicity of anthracyclines in animal studies 

      Georgiadis N., Tsarouhas K., Rezaee R., Nepka H., Kass G.E.N., Dorne J.-L.C.M., Stagkos D., Toutouzas K., Spandidos D.A., Kouretas D., Tsitsimpikou C. (2020)
      Anthracyclines are commonly used anticancer drugs with well.known and extensively studied cardiotoxic effects in humans. In the clinical setting guidelines for assessing cardiotoxicity are well.established with important ...