Listar por tema "cancer inhibition"

Advanced Non-linear Mathematical Model for the Prediction of the Activity of a Putative Anticancer Agent in Human-to-mouse Cancer Xenografts

Liliopoulos S.G., Stavrakakis G.S., Dimas K.S. (2020)

Background/Aim: Mathematical models have long been considered as important tools in cancer biology and therapy. Herein, we present an advanced non-linear mathematical model that can predict accurately the effect of an ...

Anti-invasive effects of CXCR4 and FAK inhibitors in non-small cell lung carcinomas with mutually inactivated p53 and PTEN tumor suppressors

Dragoj M., Bankovic J., Sereti E., Stojanov S.J., Dimas K., Pesic M., Stankovic T. (2017)

Non-small cell lung carcinoma (NSCLC) is the most common type of lung cancer. At the time of diagnosis, a large percentage of NSCLC patients have already developed metastasis, responsible for extremely high mortality rates. ...

Anticarcinogenic activity of polyphenolic extracts from grape stems against breast, colon, renal and thyroid cancer cells

Sahpazidou, D.; Geromichalos, G. D.; Stagos, D.; Apostolou, A.; Haroutounian, S. A.; Tsatsakis, A. M.; Tzanakakis, G. N.; Hayes, A. W.; Kouretas, D. (2014)

A major part of the wineries' wastes is composed of grape stems which are discarded mainly in open fields and cause environmental problems due mainly to their high polyphenolic content. The grape stem extracts' use as a ...

Chios mastic gum: A plant-produced resin exhibiting numerous diverse pharmaceutical and biomedical prοperties

Dimas, K. S.; Pantazis, P.; Ramanujam, R. (2012)

Chios mastic gum (CMG) is a resin produced by the plant Pistacia lentiscus var. chia. CMG is used to extract the mastic gum essential oil (MGO). CMG and MGO consist of nearly 70 constituents and have demonstrated numerous ...

Chloroquine used in combination with chemotherapy synergistically suppresses growth and angiogenesis in vitro and in vivo

Gurel-Gurevin E., Tuba Kiyan H., Esener O.B.B., Aydinlik S., Uvez A., Ulukaya E., Dimas K., Armutak E.I. (2018)

Background: The inhibition of autophagy using pharmacological inhibitors such as chloroquine may be an effective strategy to overcome chemotherapy or resistance to anti-angiogenic therapy. Materials and Methods: The cytotoxic ...

Editorial: Role of Ribonucleases in Immune Response Regulation During Infection and Cancer

Boix E., Acquati F., Leonidas D., Pulido D. (2020)

[No abstract available]

FGF-2 and HGF reverse abiraterone’s effect οn intracellular levels of DHT in androgen-dependent and androgen independent prostate cancer cell lines

Vasileiou C., Befani C., Dimas K., Liakos P., Papandreou C. (2020)

Purpose: Growth factors such as fibroblast growth factor 2 (FGF-2) and hepatocyte growth factor (HGF) appear at high levels in prostate cancer (PC). Abiraterone is an androgen biosynthesis inhibitor which is currently in ...

Focus on the use of resveratrol as an adjuvant in glioblastoma therapy

Dionigi L., Ragonese F., Monarca L., Covino S., de Luca A., Iannitti R.G., Bastioli F., Moulas A.N., Allegretti M., Fioretti B. (2020)

Glioblastoma (GB) represents the most common and malignant form of glioma cancer. The Gold Standard in Glioblastoma is neurosurgical tumor removal and radiotherapy treatment in concomitant with temo-zolomide (TMZ). ...

Immunohistochemicall expression of the p53, p21/Waf-1, Rb, p16 and Ki67 proteins in multiple myeloma

Kanavaros, P.; Stefanaki, K.; Vlachonikolis, J.; Papalazarou, D.; Rontogianni, D.; Arvanitis, D.; Antonakopoulos, G.; Gorgoulis, V.; Bai, M.; Agnantis, N. J. (2000)

The aim of this study was to investigate the immunohistochemical expression of the proteins p53, Waf-l/p21, Rb, p16 and Ki67 in 38 cases of multiple myelomas (MM) and 4 cases of solitary extramedullary plasmacytomas in ...

Istaroxime Inhibits Motility and Down-Regulates Orai1 Expression, SOCE and FAK Phosphorylation in Prostate Cancer Cells

Stagno M.J., Zacharopoulou N., Bochem J., Tsapara A., Pelzl L., Al-Maghout T., Kallergi G., Alkahtani S., Alevizopoulos K., Dimas K., Calogeropoulou T., Warmann S.W., Lang F., Schmid E., Stournaras C. (2017)

Background/Aims: Istaroxime is a validated inotropic Na + /K + ATPase inhibitor currently in development for the treatment of various cardiac conditions. Recent findings established that this steroidal drug exhibits potent ...

The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action

Mahaira, L. G.; Tsimplouli, C.; Sakellaridis, N.; Alevizopoulos, K.; Demetzos, C.; Han, Z.; Pantazis, P.; Dimas, K. (2011)

The labdane diterpene sclareol has demonstrated significant cytotoxicity against human tumor cell lines and human colon cancer xenografts. Therefore, there is need to elucidate the mode of action of this compound as very ...