• AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders 

      Salpietro V., Dixon C.L., Guo H., Bello O.D., Vandrovcova J., Efthymiou S., Maroofian R., Heimer G., Burglen L., Valence S., Torti E., Hacke M., Rankin J., Tariq H., Colin E., Procaccio V., Striano P., Mankad K., Lieb A., Chen S., Pisani L., Bettencourt C., Männikkö R., Manole A., Brusco A., Grosso E., Ferrero G.B., Armstrong-Moron J., Gueden S., Bar-Yosef O., Tzadok M., Monaghan K.G., Santiago-Sim T., Person R.E., Cho M.T., Willaert R., Yoo Y., Chae J.-H., Quan Y., Wu H., Wang T., Bernier R.A., Xia K., Blesson A., Jain M., Motazacker M.M., Jaeger B., Schneider A.L., Boysen K., Muir A.M., Myers C.T., Gavrilova R.H., Gunderson L., Schultz-Rogers L., Klee E.W., Dyment D., Osmond M., Parellada M., Llorente C., Gonzalez-Peñas J., Carracedo A., Van Haeringen A., Ruivenkamp C., Nava C., Heron D., Nardello R., Iacomino M., Minetti C., Skabar A., Fabretto A., Hanna M.G., Bugiardini E., Hostettler I., O’Callaghan B., Khan A., Cortese A., O’Connor E., Yau W.Y., Bourinaris T., Kaiyrzhanov R., Chelban V., Madej M., Diana M.C., Vari M.S., Pedemonte M., Bruno C., Balagura G., Scala M., Fiorillo C., Nobili L., Malintan N.T., Zanetti M.N., Krishnakumar S.S., Lignani G., Jepson J.E.C., Broda P., Baldassari S., Rossi P., Fruscione F., Madia F., Traverso M., De-Marco P., Pérez-Dueñas B., Munell F., Kriouile Y., El-Khorassani M., Karashova B., Avdjieva D., Kathom H., Tincheva R., Van-Maldergem L., Nachbauer W., Boesch S., Gagliano A., Amadori E., Goraya J.S., Sultan T., Kirmani S., Ibrahim S., Jan F., Mine J., Banu S., Veggiotti P., Zuccotti G.V., Ferrari M.D., Van Den Maagdenberg A.M.J., Verrotti A., Marseglia G.L., Savasta S., Soler M.A., Scuderi C., Borgione E., Chimenz R., Gitto E., Dipasquale V., Sallemi A., Fusco M., Cuppari C., Cutrupi M.C., Ruggieri M., Cama A., Capra V., Mencacci N.E., Boles R., Gupta N., Kabra M., Papacostas S., Zamba-Papanicolaou E., Dardiotis E., Maqbool S., Rana N., Atawneh O., Lim S.Y., Shaikh F., Koutsis G., Breza M., Coviello D.A., Dauvilliers Y.A., AlKhawaja I., AlKhawaja M., Al-Mutairi F., Stojkovic T., Ferrucci V., Zollo M., Alkuraya F.S., Kinali M., Sherifa H., Benrhouma H., Turki I.B.Y., Tazir M., Obeid M., Bakhtadze S., Saadi N.W., Zaki M.S., Triki C.C., Benfenati F., Gustincich S., Kara M., Belcastro V., Specchio N., Capovilla G., Karimiani E.G., Salih A.M., Okubadejo N.U., Ojo O.O., Oshinaike O.O., Oguntunde O., Wahab K., Bello A.H., Abubakar S., Obiabo Y., Nwazor E., Ekenze O., Williams U., Iyagba A., Taiwo L., Komolafe M., Senkevich K., Shashkin C., Zharkynbekova N., Koneyev K., Manizha G., Isrofilov M., Guliyeva U., Salayev K., Khachatryan S., Rossi S., Silvestri G., Haridy N., Ramenghi L.A., Xiromerisiou G., David E., Aguennouz M., Fidani L., Spanaki C., Tucci A., Raspall-Chaure M., Chez M., Tsai A., Fassi E., Shinawi M., Constantino J.N., De Zorzi R., Fortuna S., Kok F., Keren B., Bonneau D., Choi M., Benzeev B., Zara F., Mefford H.C., Scheffer I.E., Clayton-Smith J., Macaya A., Rothman J.E., Eichler E.E., Kullmann D.M., Houlden H., SYNAPS Study Group (2019)
      AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at ...
    • Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework 

      Mentis A.-F.A., Dardiotis E., Chrousos G.P. (2021)
      The potential existence and roles of the meningeal lymphatic system in normal and pathological brain function have been a long-standing enigma. Recent evidence suggests that meningeal lymphatic vessels are present in both ...
    • Associations between ghrelin and leptin and neural food cue reactivity in a fasted and sated state 

      Wever M.C.M., van Meer F., Charbonnier L., Crabtree D.R., Buosi W., Giannopoulou A., Androutsos O., Johnstone A.M., Manios Y., Meek C.L., Holst J.J., Smeets P.A.M., Full4Health consortium (2021)
      Food cue exposure can trigger eating. Food cue reactivity (FCR) is a conditioned response to food cues and includes physiological responses and activation of reward-related brain areas. FCR can be affected by hunger and ...
    • Brain diseases in changing climate 

      Ruszkiewicz J.A., Tinkov A.A., Skalny A.V., Siokas V., Dardiotis E., Tsatsakis A., Bowman A.B., da Rocha J.B.T., Aschner M. (2019)
      Climate change is one of the biggest and most urgent challenges for the 21st century. Rising average temperatures and ocean levels, altered precipitation patterns and increased occurrence of extreme weather events affect ...
    • Brain volume dynamics in multiple sclerosis. A case-control study 

      Andravizou A., Artemiadis A., Bakirtzis C., Siokas V., Aloizou A.-M., Peristeri E., Kapsalaki E., Tsimourtou V., Hadjigeorgiou G.M., Dardiotis E. (2019)
      Objectives: In this study, we aimed to explore the extent and clinical relevance of brain volume dynamics in relapsing remitting multiple sclerosis (RRMS). Methods: Sixty-three patients with RRMS with a disease duration ...
    • Case Report of Transmissible Gastroenteritis Coronavirus Infection Associated with Small Intestine and Brain Lesions in Piglets 

      Papatsiros V.G., Stylianaki I., Papakonstantinou G., Papaioannou N., Christodoulopoulos G. (2019)
      This case study report describes a transmissible gastroenteritis coronavirus (TGEV) infection presented in a commercial pig herd. The clinical signs of infection appeared in newborn piglets, including medium morbidity and ...
    • Cerebral and non-cerebral coenurosis: on the genotypic and phenotypic diversity of Taenia multiceps 

      Christodoulopoulos G., Dinkel A., Romig T., Ebi D., Mackenstedt U., Loos-Frank B. (2016)
      We characterised the causative agents of cerebral and non-cerebral coenurosis in livestock by determining the mitochondrial genotypes and morphological phenotypes of 52 Taenia multiceps isolates from a wide geographical ...
    • Clinically reliable cognitive decline in relapsing remitting multiple sclerosis: Is it the tip of the iceberg? 

      Andravizou A., Siokas V., Artemiadis A., Bakirtzis C., Aloizou A.-M., Grigoriadis N., Kosmidis M.H., Nasios G., Messinis L., Hadjigeorgiou G., Dardiotis E., Peristeri E. (2020)
      Objectives: Cognitive impairment is common in multiple sclerosis, but the brain MRI correlates in relapsing remitting multiple sclerosis remain controversial. The current study aimed to investigate whether cognitive decline ...
    • Cognitive deficits in myopathies 

      Peristeri E., Aloizou A.-M., Keramida P., Tsouris Z., Siokas V., Mentis A.-F.A., Dardiotis E. (2020)
      Myopathies represent a wide spectrum of heterogeneous diseases mainly characterized by the abnormal structure or functioning of skeletal muscle. The current paper provides a comprehensive overview of cognitive deficits ...
    • Common and Uncommon Artifacts in T1 FLAIR SAG Sequences of MRI Brain 

      Lavdas E., Papaioannou M., Boci N., Dardiotis E., Roka V., Sakkas G.K., Apostolopoulou G., Gogou L., Mavroidis P. (2021)
      Objective: This study aims at identifying, classifying, and measuring the frequency the different artifacts that show up in the images of the Sagittal T1 Fluid Attenuated Inversion Recovery (FLAIR) sequence. Materials and ...
    • Connexin43 and Connexin47 Alterations after Neural Precursor Cells Transplantation in Experimental Autoimmune Encephalomyelitis 

      Theotokis, P.; Kleopa, K. A.; Touloumi, O.; Lagoudaki, R.; Lourbopoulos, A.; Nousiopoulou, E.; Kesidou, E.; Poulatsidou, K. N.; Dardiotis, E.; Hadjigeorgiou, G.; Karacostas, D.; Cifuentes-Diaz, C.; Irinopoulou, T.; Grigoriadis, N. (2015)
      Exogenous transplanted neural precursor cells (NPCs) exhibit miscellaneous immune-modulatory effects in models of autoimmune demyelination. However, the regional interactions of NPCs with the host brain tissue in remissive ...
    • Critical Appraisal of Randomized Controlled Trials on Unruptured Brain Arteriovenous Malformations 

      Tasiou A., Brotis A.G., Tzerefos C., Lambrianou X., Spiliotopoulos T., Alleyne C.H., Jr., Boccardi E., Karlsson B., Kitchen N., Meling T.R., Spetzler R.F., Tolias C.M., Fountas K.N. (2022)
      Objective: Brain arteriovenous malformations management remains controversial despite the numerous, available treatment options. Randomized controlled trials (RCTs) theoretically provide the strongest evidence for the ...
    • Differential diagnosis of behavioral variant and semantic variant of frontotemporal dementia using visual rating scales 

      Manouvelou S., Koutoulidis V., Tsougos I., Tolia M., Kyrgias G., Anyfantakis G., Moulopoulos L.-A., Gouliamos A., Papageorgiou S. (2020)
      Background: Frontotemporal dementia (FTD) represents the second most frequent early onset of dementia in people younger than 65 years. The main syndromes encompassed by the term FTD are behavioral variant of Frontotemporal ...
    • Direct oral anticoagulant-vs Vitamin K antagonist-related nontraumatic intracerebral hemorrhage 

      Tsivgoulis G., Lioutas V.-A., Varelas P., Katsanos A.H., Goyal N., Mikulik R., Barlinn K., Krogias C., Sharma V.K., Vadikolias K., Dardiotis E., Karapanayiotides T., Pappa A., Zompola C., Triantafyllou S., Kargiotis O., Ioakeimidis M., Giannopoulos S., Kerro A., Tsantes A., Mehta C., Jones M., Schroeder C., Norton C., Bonakis A., Chang J., Alexandrov A.W., Mitsias P., Alexandrov A.V. (2017)
      Objective: To compare the neuroimaging profile and clinical outcomes among patients with intracerebral hemorrhage (ICH) related to use of vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) for nonvalvular ...
    • The Effectiveness of Non-Invasive Brain Stimulation Alone or Combined with Cognitive Training on the Cognitive Performance of Patients with Traumatic Brain Injury: A Systematic Review 

      Nousia A., Martzoukou M., Liampas I., Siokas V., Bakirtzis C., Nasios G., Dardiotis E. (2022)
      Objective: The present study reviewed published evidence on the effectiveness of non-invasive brain stimulation (NIBS) on the cognitive performance of patients with Traumatic brain injury (TBI). Method: A systematic search ...
    • Effects of sheep/goat whey protein dietary supplementation on the redox status of rats 

      Kerasioti E., Stagos D., Tsatsakis A.M., Spandidos D.A., Taitzoglou I., Kouretas D. (2018)
      The purpose of the present study is to estimate the effects of sheep/goat whey protein dietary supplementation on the redox status of blood and tissues of rats. Twelve male Wistar rats were divided into the control group ...
    • The frequency of central nervous system complications in the Cypriot cohort of ATTRV30M neuropathy transplanted patients 

      Dardiotis E., Andreou S., Aloizou A.-M., Panayiotou E., Siokas V., Ioannou M.N., Vounou E., Christodoulou K., Tanteles G.A., Michaelides D., Kyriakides T. (2020)
      Background: Hereditary transthyretin amyloidosis (ATTR) is a hereditary, sensorimotor and autonomic neuropathy caused by deposits of mutated transthyretin (TTR). The commonest TTR mutation is V30M (ATTRV30M) with patients ...
    • From Broca and Wernicke to the Neuromodulation Era: Insights of Brain Language Networks for Neurorehabilitation 

      Nasios G., Dardiotis E., Messinis L. (2019)
      Communication in humans activates almost every part of the brain. Of course, the use of language predominates, but other cognitive functions such as attention, memory, emotion, and executive processes are also involved. ...