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Πλοήγηση ανά Θέμα "biliary cirrhosis"

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    • Altered DNA methylation pattern characterizes the peripheral immune cells of patients with autoimmune hepatitis 

      Zachou K., Arvaniti P., Lyberopoulou A., Sevdali E., Speletas M., Ioannou M., Koukoulis G.K., Renaudineau Y., Dalekos G.N. (2022)
      Background and Aims: Little is known about the impact of DNA methylation modifications on autoimmune hepatitis (AIH) pathogenesis and therapeutic response. We investigated the potential alterations of DNA methylation in ...

    • Assessment of health related quality of life in polish patients with primary biliary cirrhosis 

      Raszeja-Wyszomirska J., Wunsch E., Krawczyk M., Rigopoulou E.I., Kostrzewa K., Norman G.L., Bogdanos D.P., Milkiewicz P. (2016)
      Background Most patients with primary biliary cirrhosis (PBC) have impaired health related quality of life (HRQoL), as assessed by PBC-specific HRQoL (PBC-40) and generic (SF-36) questionnaires. Data on the applicability ...

    • Bone marrow findings in patients with autoimmune liver diseases 

      Tsikrikoni, A.; Rigopoulou, E. I.; Zachou, K.; Liaskos, C.; Kyriakou, D.; Dalekos, G. N. (2008)
      Background and Aims: We have recently reported quantitative and qualitative differences of the bone marrow (BM) hematopoietic progenitor cells in autoimmune hepatitis type-1 (AIH-1) and primary biliary cirrhosis (PBC). In ...

    • The challenges of primary biliary cholangitis: What is new and what needs to be done 

      Terziroli Beretta-Piccoli B., Mieli-Vergani G., Vergani D., Vierling J.M., Adams D., Alpini G., Banales J.M., Beuers U., Björnsson E., Bowlus C., Carbone M., Chazouillères O., Dalekos G., De Gottardi A., Harada K., Hirschfield G., Invernizzi P., Jones D., Krawitt E., Lanzavecchia A., Lian Z.-X., Ma X., Manns M., Mavilio D., Quigley E.M., Sallusto F., Shimoda S., Strazzabosco M., Swain M., Tanaka A., Trauner M., Tsuneyama K., Zigmond E., Gershwin M.E. (2019)
      Primary Biliary Cholangitis (PBC) is an uncommon, chronic, cholangiopathy of autoimmune origin and unknown etiology characterized by positive anti-mitochondrial autoantibodies (AMA), female preponderance and progression ...

    • Enhanced expression of miR-21 and miR-150 is a feature of anti-mitochondrial antibody-negative primary biliary cholangitis 

      Wasik U., Kempinska-Podhorodecka A., Bogdanos D.P., Milkiewicz P., Milkiewicz M. (2020)
      Background & Aims: Anti-mitochondrial-autoantibodies (AMA) remain a hallmark of Primary Biliary Cholangitis (PBC) however approximately 10% of patients test negative for these antibodies. They do not differ in terms of ...

    • Factors Associated With Progression and Outcomes of Early Stage Primary Biliary Cholangitis 

      Gatselis N.K., Goet J.C., Zachou K., Lammers W.J., Janssen H.L.A., Hirschfield G., Corpechot C., Lindor K.D., Invernizzi P., Mayo M.J., Battezzati P.M., Floreani A., Pares A., Lygoura V., Nevens F., Mason A.L., Kowdley K.V., Ponsioen C.Y., Bruns T., Thorburn D., Verhelst X., Harms M.H., van Buuren H.R., Hansen B.E., Dalekos G.N., Global Primary Biliary Cholangitis Study Group (2020)
      Background & Aims: Patients usually receive a diagnosis of primary biliary cholangitis (PBC) at an early stage, based on biochemical analyses. We investigated the proportion of patients who progress to moderate or advanced ...

    • FibroMeter scores for the assessment of liver fibrosis in patients with autoimmune liver diseases 

      Zachou K., Lygoura V., Arvaniti P., Giannoulis G., Gatselis N.K., Koukoulis G.K., Dalekos G.N. (2021)
      Introduction and Objectives: We assessed FibroMeter virus (FMvirus) and FibroMeter vibration-controlled transient elastography (FMVCTE) in 134 patients with autoimmune liver diseases [ALD, autoimmune hepatitis (AIH) and ...

    • Geoepidemiology, clinical manifestations and outcome of primary biliary cholangitis in Greece 

      Gatselis N.K., Zachou K., Lygoura V., Azariadis K., Arvaniti P., Spyrou E., Papadamou G., Koukoulis G.K., Dalekos G.N., Rigopoulou E.I. (2017)
      Background & aims Primary biliary cholangitis (PBC) is a disease with rising prevalence and considerable geographical variation. To describe the prevalence, spatial and time distribution, baseline characteristics, response ...

    • Increased cholestatic enzymes in two patients with long-term history of ulcerative colitis: Consider primary biliary cholangitis not always primary sclerosing cholangitis 

      Polychronopoulou E., Lygoura V., Gatselis N.K., Dalekos G.N. (2017)
      Several hepatobiliary disorders have been reported in ulcerative colitis (UC) patients with primary sclerosing cholangitis (PSC) being the most specific. Primary biliary cholangitis (PBC), previously known as primary biliary ...

    • Major hepatic complications in ursodeoxycholic acid-treated patients with primary biliary cholangitis: Risk factors and time trends in incidence and outcome 

      Harms M.H., Lammers W.J., Thorburn D., Corpechot C., Invernizzi P., Janssen H.L.A., Battezzati P.M., Nevens F., Lindor K.D., Floreani A., Ponsioen C.Y., Mayo M.J., Dalekos G.N., Bruns T., Parés A., Mason A.L., Verhelst X., Kowdley K.V., Goet J.C., Hirschfield G.M., Hansen B.E., Van Buuren H.R. (2018)
      Objectives: In this era of near universal ursodeoxycholic acid (UDCA) treatment for primary biliary cholangitis (PBC), progression to cirrhosis still occurs in an important proportion of patients. The aim of this study was ...

    • Milder disease stage in patients with primary biliary cholangitis over a 44-year period: A changing natural history 

      Murillo Perez C.F., Goet J.C., Lammers W.J., Gulamhusein A., van Buuren H.R., Ponsioen C.Y., Carbone M., Mason A., Corpechot C., Invernizzi P., Mayo M.J., Battezzati P.M., Floreani A., Pares A., Nevens F., Kowdley K.V., Bruns T., Dalekos G.N., Thorburn D., Hirschfield G., LaRusso N.F., Lindor K.D., Zachou K., Poupon R., Trivedi P.J., Verhelst X., Janssen H.L.A., Hansen B.E., on behalf of the GLOBAL PBC Study Group (2018)
      Changes over time in the presenting features and clinical course of patients with primary biliary cholangitis are poorly described. We sought to describe temporal trends in patient and disease characteristics over a 44-year ...

    • The role of invariant NKT in autoimmune liver disease: Can Vitamin D Act as an Immunomodulator? 

      Smyk D.S., Mavropoulos A., Mieli-Vergani G., Vergani D., Lenzi M., Bogdanos D.P. (2018)
      Natural killer T (NKT) cells are a distinct lineage of T cells which express both the T cell receptor (TCR) and natural killer (NK) cell markers. Invariant NKT (iNKT) cells bear an invariant TCR and recognize a small variety ...