Πλοήγηση ανά Θέμα "antinuclear antibody"

Arthritis and Myositis in a Patient Treated with Programmed Cell Death-1 (PD-1) Inhibitor Pembrolizumab for Lung Cancer

Pagkopoulou E., Simopoulou T., Maragkouli E., Perifanou-Sotiri S., Kotsakis A., Bogdanos D.P. (2020)

Immune checkpoint inhibitors (ICIs) are a new class of drug that have demonstrated efficacy across many cancer types. Because of their nature and mode of action, ICIs unleash immune activation raising concerns as to whether ...

Autoantibodies against specific nuclear antigens are present in psoriatic disease and are diminished by secukinumab

Patrikiou E., Liaskos C., Mavropoulos A., Ntavari N., Gkoutzourelas A., Simopoulou T., Fechner K., Scheper T., Meyer W., Katsiari C.G., Roussaki-Schulze A., Zafiriou E., Sakkas L.I., Bogdanos D.P. (2020)

Anti-nuclear antibodies (ANA) are frequently detected in patients with psoriasis (Ps) and psoriatic arthritis (PsA), but their target autoantigens remain unknown. We assessed antibody (ab) reactivity against 23 known nuclear ...

Autoantibodies in autoimmune pancreatitis

Smyk, D. S.; Rigopoulou, E. I.; Koutsoumpas, A. L.; Kriese, S.; Burroughs, A. K.; Bogdanos, D. P. (2012)

Autoimmune pancreatitis (AIP) was first used to describe cases of pancreatitis with narrowing of the pancreatic duct, enlargement of the pancreas, hyper - globulinaemia, and antinuclear antibody (ANA) positivity serologically. ...

Belimumab is a promising third-line treatment option for refractory autoimmune hepatitis

Arvaniti P., Giannoulis G., Gabeta S., Zachou K., Koukoulis G.K., Dalekos G.N. (2020)

Background & Aims: Autoimmune hepatitis (AIH) is a disease of unknown aetiology with a favourable response to immunosuppression. However, in the clinic, it appears that <50% of patients achieve complete response on standard ...

A case of membranous nephropathy associated with Sjögren syndrome, polymyositis and autoimmune hepatitis

Stefanidis, I.; Giannopoulou, M.; Liakopoulos, V.; Dovas, S.; Karasavvidou, F.; Zachou, K.; Koukoulis, G. K.; Dalekos, G. N. (2008)

Sjögren syndrome (SS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, especially lacrimal and salivary. The immunologic process which occurs in this syndrome is B cell ...

The challenges of primary biliary cholangitis: What is new and what needs to be done

Terziroli Beretta-Piccoli B., Mieli-Vergani G., Vergani D., Vierling J.M., Adams D., Alpini G., Banales J.M., Beuers U., Björnsson E., Bowlus C., Carbone M., Chazouillères O., Dalekos G., De Gottardi A., Harada K., Hirschfield G., Invernizzi P., Jones D., Krawitt E., Lanzavecchia A., Lian Z.-X., Ma X., Manns M., Mavilio D., Quigley E.M., Sallusto F., Shimoda S., Strazzabosco M., Swain M., Tanaka A., Trauner M., Tsuneyama K., Zigmond E., Gershwin M.E. (2019)

Primary Biliary Cholangitis (PBC) is an uncommon, chronic, cholangiopathy of autoimmune origin and unknown etiology characterized by positive anti-mitochondrial autoantibodies (AMA), female preponderance and progression ...

Clinical immunology quiz - Case 4

Kalala, F.; Mamara, A.; Theodoridou, A. T.; Speletas, M. (2008)

Clinical significance of organ- and non-organ-specific autoantibodies on the response to anti-viral treatment of patients with chronic hepatitis C

Gatselis, N. K.; Georgiadou, S. P.; Koukoulis, G. K.; Tassopoulos, N.; Zachou, K.; Liaskos, C.; Hatzakis, A.; Dalekos, G. N. (2006)

Background: Development of organ- and non-organ-specific autoantibodies has been reported in hepatitis C virus patients treated with interferon-α plus/minus ribavirin. Aims: To address whether prevalence and the titre of ...

A comprehensive analysis of antigen-specific antibody responses against human cytomegalovirus in patients with systemic sclerosis

Efthymiou G., Dardiotis E., Liaskos C., Marou E., Scheper T., Meyer W., Daponte A., Daoussis D., Hadjigeorgiou G., Bogdanos D.P., Sakkas L.I. (2019)

Anti-human cytomegalovirus (HCMV) antibodies are considered triggers of systemic sclerosis (SSc), but such a hypothesis has been assessed in limited sub-dominant epitopes. Our aim was to systematically assess the potential ...

A comprehensive analysis of antigen-specific autoimmune liver disease related autoantibodies in patients with multiple sclerosis

Tsouris Z., Liaskos C., Dardiotis E., Scheper T., Tsimourtou V., Meyer W., Hadjigeorgiou G., Bogdanos D.P. (2020)

Introduction: Abnormal liver function tests are frequently seen in patients with multiple sclerosis (MS) and their origin at times is attributed to the possible co-occurrence or the de novo induction of autoimmune liver ...

Current laboratory and clinical practices in reporting and interpreting anti-nuclear antibody indirect immunofluorescence (ANA IIF) patterns: results of an international survey

Van Hoovels L., Broeders S., Chan E.K.L., Andrade L., de Melo Cruvinel W., Damoiseaux J., Viander M., Herold M., Coucke W., Heijnen I., Bogdanos D., Calvo-Alén J., Eriksson C., Kozmar A., Kuhi L., Bonroy C., Lauwerys B., Schouwers S., Lutteri L., Vercammen M., Mayer M., Patel D., Egner W., Puolakka K., Tesija-Kuna A., Shoenfeld Y., de Sousa M.J.R., Hoyos M.L., Radice A., Bossuyt X. (2020)

Background: The International Consensus on Antinuclear Antibody (ANA) Patterns (ICAP) has recently proposed nomenclature in order to harmonize ANA indirect immunofluorescence (IIF) pattern reporting. ICAP distinguishes ...

Early primary biliary cirrhosis: A new association with erythema nodosum of unknown origin

Dalekos, G. N.; Gatselis, N. K.; Zachou, K. (2010)

Primary biliary cirrhosis (PBC) is associated with immune-mediated dermatologic disorders. The association of PBC with erythema nodosum (EN) seems rare. We report two females (42 and 44 years old) with low-grade fever, ...

IL-10-producing regulatory B cells (B10 cells), IL-17 + T cells and autoantibodies in systemic sclerosis

Mavropoulos A., Liaskos C., Simopoulou T., Bogdanos D.P., Sakkas L.I. (2017)

We aimed to analyze IL-10 + Breg (B10) cells, found to be reduced in systemic sclerosis (SSc), in relation to SSc-specific autoAbs and IL-17 + and IFNγ + T cells in SSc. Peripheral blood B10 cells from 26 patients with SSc ...

The immunopathogenetic role of autoantibodies in canine autoimmune hepatitis: Lessons to learn from human autoimmune hepatitis

Liaskos, C.; Mavropoulos, A.; Orfanidou, T.; Spyrou, V.; Athanasiou, L. V.; Billinis, C. (2012)

Autoimmune hepatitis (AIH) is not a disease entity restricted to man, but it can be found in other animals including canines. An increasing number of studies have focused on the immunopathogenesis of human autoimmune ...

Increased cholestatic enzymes in two patients with long-term history of ulcerative colitis: Consider primary biliary cholangitis not always primary sclerosing cholangitis

Polychronopoulou E., Lygoura V., Gatselis N.K., Dalekos G.N. (2017)

Several hepatobiliary disorders have been reported in ulcerative colitis (UC) patients with primary sclerosing cholangitis (PSC) being the most specific. Primary biliary cholangitis (PBC), previously known as primary biliary ...