• Acceptability of covid-19 vaccination among greek health professionals 

      Papagiannis D., Rachiotis G., Malli F., Papathanasiou I.V., Kotsiou O., Fradelos E.C., Giannakopoulos K., Gourgoulianis K.I. (2021)
      Health Care Workers are at the front line of the fight against Covid-19. The aim of this study was to evaluate the acceptability of vaccination against COVID-19 among health professionals (physi-cians, dentists, pharmacists) ...
    • Antipsychotic dose reduction compared to dose continuation for people with schizophrenia 

      Rodolico A., Siafis S., Bighelli I., Samara M.T., Hansen W.-P., Salomone S., Aguglia E., Cutrufelli P., Bauer I., Baeckers L., Leucht S. (2022)
      Background: Antipsychotic drugs are the mainstay treatment for schizophrenia, yet they are associated with diverse and potentially dose-related side effects which can reduce quality of life. For this reason, the lowest ...
    • Antipsychotic polypharmacy reduction versus polypharmacy continuation for people with schizophrenia 

      Bighelli I., Rodolico A., Siafis S., Samara M.T., Hansen W.-P., Salomone S., Aguglia E., Cutrufelli P., Bauer I., Baeckers L., Leucht S. (2022)
      Background: In clinical practice, different antipsychotics can be combined in the treatment of people with schizophrenia (polypharmacy). This strategy can aim at increasing efficacy, but might also increase the adverse ...
    • Association of ITPA gene polymorphisms with adverse effects of AZA/6-MP administration: a systematic review and meta-analysis 

      Barba E., Kontou P.I., Michalopoulos I., Bagos P.G., Braliou G.G. (2022)
      Azathioprine (AZA) and its metabolite, mercaptopurine (6-MP), are widely used immunosuppressant drugs. Polymorphisms in genes implicated in AZA/6-MP metabolism, reportedly, could account in part for their potential toxicity. ...
    • Benefits and Limitations of TKIs in Patients with Medullary Thyroid Cancer: A Systematic Review and Meta-Analysis 

      Efstathiadou Z.A., Tsentidis C., Bargiota A., Daraki V., Kotsa K., Ntali G., Papanastasiou L., Tigas S., Toulis K., Pazaitou-Panayiotou K., Alevizaki M. (2021)
      Introduction: Tyrosine kinase inhibitors (TKIs) have been used in patients with advanced medullary thyroid carcinoma (MTC); however, data on their effectiveness and safety are limited. The aim of this systematic review and ...
    • Drug-Induced Skin Adverse Reactions: The Role of Pharmacogenomics in Their Prevention 

      Gerogianni K., Tsezou A., Dimas K. (2018)
      Adverse drug reactions (ADRs) affect many patients and remain a major public health problem, as they are a common cause of morbidity and mortality. It is estimated that ADRs are responsible for about 6% of hospital admissions ...
    • Haplotype structure defines effects of common DPYD variants c.85T > C (rs1801265) and c.496A > G (rs2297595) on dihydropyrimidine dehydrogenase activity: Implication for 5-fluorouracil toxicity 

      Hamzic S., Schärer D., Offer S.M., Meulendijks D., Nakas C., Diasio R.B., Fontana S., Wehrli M., Schürch S., Amstutz U., Largiadèr C.R. (2021)
      Aims: The aim of this study was to identify risk variants and haplotypes that impair dihydropyrimidine dehydrogenase (DPD) activity and are, therefore, candidate risk variants for severe toxicity to 5-fluorouracil (5-FU) ...
    • Healthcare access and quality index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: A novel analysis from the global burden of disease study 2015 

      Barber R.M., Fullman N., Sorensen R.J.D., Bollyky T., McKee M., Nolte E., Abajobir A.A., Abate K.H., Abbafati C., Abbas K.M., Abd-Allah F., Abdulle A.M., Abdurahman A.A., Abera S.F., Abraham B., Abreha G.F., Adane K., Adelekan A.L., Adetifa I.M.O., Afshin A., Agarwal A., Agarwal S.K., Agarwal S., Agrawal A., Ahmad Kiadaliri A., Ahmadi A., Ahmed K.Y., Ahmed M.B., Akinyemi R.O., Akinyemiju T.F., Akseer N., Al-Aly Z., Alam K., Alam N., Alam S.S., Alemu Z.A., Alene K.A., Alexander L., Ali R., Ali S.D., Alizadeh-Navaei R., Alkerwi A., Alla F., Allebeck P., Allen C., Al-Raddadi R., Alsharif U., Altirkawi K.A., Alvarez Martin E., Alvis-Guzman N., Amare A.T., Amini E., Ammar W., Amo-Adjei J., Amoako Y.A., Anderson B.O., Androudi S., Ansari H., Ansha M.G., Antonio C.A.T., Ärnlöv J., Artaman A., Asayesh H., Assadi R., Astatkie A., Atey T.M., Atique S., Atnafu N.T., Atre S.R., Avila-Burgos L., Avokpaho E.F.G.A., Ayala Quintanilla B.P., Awasthi A., Ayele N.N., Azzopardi P., Ba Saleem H.O., Bärnighausen T., Bacha U., Badawi A., Banerjee A., Barac A., Barboza M.A., Barker-Collo S.L., Barrero L.H., Basu S., Baune B.T., Baye K., Bayou Y.T., Bazargan-Hejazi S., Bedi N., Beghi E., Béjot Y., Bello A.K., Bennett D.A., Bensenor I.M., Berhane A., Bernabé E., Bernal O.A., Beyene A.S., Beyene T.J., Bhutta Z.A., Biadgilign S., Bikbov B., Birlik S.M., Birungi C., Biryukov S., Bisanzio D., Bizuayehu H.M., Bose D., Brainin M., Brauer M., Brazinova A., Breitborde N.J.K., Brenner H., Butt Z.A., Cárdenas R., Cahuana-Hurtado L., Campos-Nonato I.R., Car J., Carrero J.J., Casey D., Caso V., Castañeda-Orjuela C.A., Castillo Rivas J., Catalá-López F., Cecilio P., Cercy K., Charlson F.J., Chen A.Z., Chew A., Chibalabala M., Chibueze C.E., Chisumpa V.H., Chitheer A.A., Chowdhury R., Christensen H., Christopher D.J., Ciobanu L.G., Cirillo M., Coggeshall M.S., Cooper L.T., Cortinovis M., Crump J.A., Dalal K., Danawi H., Dandona L., Dandona R., Dargan P.I., Das Neves J., Davey G., Davitoiu D.V., Davletov K., De Leo D., Del Gobbo L.C., Del Pozo-Cruz B., Dellavalle R.P., Deribe K., Deribew A., Des Jarlais D.C., Dey S., Dharmaratne S.D., Dicker D., Ding E.L., Dokova K., Dorsey E.R., Doyle K.E., Dubey M., Ehrenkranz R., Ellingsen C.L., Elyazar I., Enayati A., Ermakov S.P., Eshrati B., Esteghamati A., Estep K., Fürst T., Faghmous I.D.A., Fanuel F.B.B., Faraon E.J.A., Farid T.A., Farinha C.S.E.S., Faro A., Farvid M.S., Farzadfar F., Feigin V.L., Feigl A.B., Fereshtehnejad S.-M., Fernandes J.G., Fernandes J.C., Feyissa T.R., Fischer F., Fitzmaurice C., Fleming T.D., Foigt N., Foreman K.J., Forouzanfar M.H., Franklin R.C., Frostad J., Ghiwot T.T., Gakidou E., Gambashidze K., Gamkrelidze A., Gao W., Garcia-Basteiro A.L., Gebre T., Gebremedhin A.T., Gebremichael M.W., Gebru A.A., Gelaye A.A., Geleijnse J.M., Genova-Maleras R., Gibney K.B., Giref A.Z., Gishu M.D., Giussani G., Godwin W.W., Gold A., Goldberg E.M., Gona P.N., Goodridge A., Gopalani S.V., Goto A., Graetz N., Greaves F., Griswold M., Guban P.I., Gugnani H.C., Gupta P.C., Gupta R., Gupta R., Gupta T., Gupta V., Habtewold T.D., Hafezi-Nejad N., Haile D., Hailu A.D., Hailu G.B., Hakuzimana A., Hamadeh R.R., Hambisa M.T., Hamidi S., Hammami M., Hankey G.J., Hao Y., Harb H.L., Hareri H.A., Haro J.M., Hassanvand M.S., Havmoeller R., Hay R.J., Hay S.I., Hendrie D., Heredia-Pi I.B., Hoek H.W., Horino M., Horita N., Hosgood H.D., Htet A.S., Hu G., Huang H., Huang J.J., Huntley B.M., Huynh C., Iburg K.M., Ileanu B.V., Innos K., Irenso A.A., Jahanmehr N., Jakovljevic M.B., James P., James S.L., Javanbakht M., Jayaraman S.P., Jayatilleke A.U., Jeemon P., Jha V., John D., Johnson C., Johnson S.C., Jonas J.B., Juel K., Kabir Z., Kalkonde Y., Kamal R., Kan H., Karch A., Karema C.K., Karimi S.M., Kasaeian A., Kassebaum N.J., Kastor A., Katikireddi S.V., Kazanjan K., Keiyoro P.N., Kemmer L., Kemp A.H., Kengne A.P., Kerbo A.A., Kereselidze M., Kesavachandran C.N., Khader Y.S., Khalil I., Khan A.R., Khan E.A., Khan G., Khang Y.-H., Khoja A.T.A., Khonelidze I., Khubchandani J., Kibret G.D., Kim D., Kim P., Kim Y.J., Kimokoti R.W., Kinfu Y., Kissoon N., Kivipelto M., Kokubo Y., Kolk A., Kolte D., Kopec J.A., Kosen S., Koul P.A., Koyanagi A., Kravchenko M., Krishnaswami S., Krohn K.J., Kuate Defo B., Kucuk Bicer B., Kuipers E.J., Kulkarni V.S., Kumar G.A., Kumsa F.A., Kutz M., Kyu H.H., Lager A.C.J., Lal A., Lal D.K., Lalloo R., Lallukka T., Lan Q., Langan S.M., Lansingh V.C., Larson H.J., Larsson A., Laryea D.O., Latif A.A., Lawrynowicz A.E.B., Leasher J.L., Leigh J., Leinsalu M., Leshargie C.T., Leung J., Leung R., Levi M., Liang X., Lim S.S., Lind M., Linn S., Lipshultz S.E., Liu P., Liu Y., Lo L.-T., Logroscino G., Lopez A.D., Lorch S.A., Lotufo P.A., Lozano R., Lunevicius R., Lyons R.A., Macarayan E.R.K., Mackay M.T., Magdy Abd El Razek H., Magdy Abd El Razek M., Mahdavi M., Majeed A., Malekzadeh R., Malta D.C., Mantovani L.G., Manyazewal T., Mapoma C.C., Marcenes W., Marks G.B., Marquez N., Martinez-Raga J., Marzan M.B., Massano J., Mathur M.R., Maulik P.K., Mazidi M., McAlinden C., McGrath J.J., McNellan C., Meaney P.A., Mehari A., Mehndiratta M.M., Meier T., Mekonnen A.B., Meles K.G., Memish Z.A., Mengesha M.M., Mengiste D.T., Mengistie M.A., Menota B.G., Mensah G.A., Mereta S.T., Meretoja A., Meretoja T.J., Mezgebe H.B., Micha R., Millear A., Mills E.J., Minnig S., Mirarefin M., Mirrakhimov E.M., Mock C.N., Mohammad K.A., Mohammed S., Mohanty S.K., Mokdad A.H., Mola G.L.D., Molokhia M., Monasta L., Montico M., Moradi-Lakeh M., Moraga P., Morawska L., Mori R., Moses M., Mueller U.O., Murthy S., Musa K.I., Nachega J.B., Nagata C., Nagel G., Naghavi M., Naheed A., Naldi L., Nangia V., Nascimento B.R., Negoi I., Neupane S.P., Newton C.R., Ng M., Ngalesoni F.N., Ngunjiri J.W., Nguyen G., Ningrum D.N.A., Nolte S., Nomura M., Norheim O.F., Norrving B., Noubiap J.J.N., Obermeyer C.M., Ogbo F.A., Oh I.-H., Okoro A., Oladimeji O., Olagunju A.T., Olivares P.R., Olsen H.E., Olusanya B.O., Olusanya J.O., Opio J.N., Oren E., Ortiz A., Osborne R.H., Osman M., Owolabi M.O., Mahesh P.A., Pain A.W., Pakhale S., Palomares Castillo E., Pana A., Papachristou C., Parsaeian M., Patel T., Patton G.C., Paudel D., Paul V.K., Pearce N., Pereira D.M., Perez-Padilla R., Perez-Ruiz F., Perico N., Pesudovs K., Petzold M., Phillips M.R., Pigott D.M., Pillay J.D., Pinho C., Polinder S., Pond C.D., Prakash V., Purwar M., Qorbani M., Quistberg D.A., Radfar A., Rafay A., Rahimi K., Rahimi-Movaghar V., Rahman M., Rahman M.H.U., Rai R.K., Ram U., Rana S.M., Rankin Z., Rao P.V., Rao P.C., Rawaf S., Rego M.A.S., Reitsma M., Remuzzi G., Renzaho A.M.N.N., Resnikoff S., Rezaei S., Rezai M.S., Ribeiro A.L., Roba H.S., Rokni M.B., Ronfani L., Roshandel G., Roth G.A., Rothenbacher D., Roy N.K., Sachdev P.S., Sackey B.B., Saeedi M.Y., Safiri S., Sagar R., Sahraian M.A., Saleh M.M., Salomon J.A., Samy A.M., Sanabria J.R., Sanchez-Niño M.D., Sandar L., Santos I.S., Santos J.V., Santric Milicevic M.M., Sarmiento-Suarez R., Sartorius B., Satpathy M., Savic M., Sawhney M., Saylan M.I., Schöttker B., Schutte A.E., Schwebel D.C., Seedat S., Seid A.M., Seifu C.N., Sepanlou S.G., Serdar B., Servan-Mori E.E., Setegn T., Shackelford K.A., Shaheen A., Shahraz S., Shaikh M.A., Shakh-Nazarova M., Shamsipour M., Shariful Islam S.M., Sharma J., Sharma R., She J., Sheikhbahaei S., Shen J., Shi P., Shigematsu M., Shin M.-J., Shiri R., Shoman H., Shrime M.G., Sibamo E.L.S., Sigfusdottir I.D., Silva D.A.S., Silveira D.G.A., Sindi S., Singh A., Singh J.A., Singh O.P., Singh P.K., Singh V., Sinke A.H., Sinshaw A.E., Skirbekk V., Sliwa K., Smith A., Sobngwi E., Soneji S., Soriano J.B., Sousa T.C.M., Sposato L.A., Sreeramareddy C.T., Stathopoulou V., Steel N., Steiner C., Steinke S., Stokes M.A., Stranges S., Strong M., Stroumpoulis K., Sturua L., Sufiyan M.B., Suliankatchi R.A., Sun J., Sur P., Swaminathan S., Sykes B.L., Tabarés-Seisdedos R., Tabb K.M., Taffere G.R., Talongwa R.T., Tarajia M., Tavakkoli M., Taveira N., Teeple S., Tegegne T.K., Tehrani-Banihashemi A., Tekelab T., Tekle D.Y., Temam Shifa G., Terkawi A.S., Tesema A.G., Thakur J.S., Thomson A.J., Tillmann T., Tiruye T.Y., Tobe-Gai R., Tonelli M., Topor-Madry R., Tortajada M., Troeger C., Truelsen T., Tura A.K., Uchendu U.S., Ukwaja K.N., Undurraga E.A., Uneke C.J., Uthman O.A., Van Boven J.F.M., Van Dingenen R., Varughese S., Vasankari T., Venketasubramanian N., Violante F.S., Vladimirov S.K., Vlassov V.V., Vollset S.E., Vos T., Wagner J.A., Wakayo T., Waller S.G., Walson J.L., Wang H., Wang Y.-P., Watkins D.A., Weiderpass E., Weintraub R.G., Wen C.-P., Werdecker A., Wesana J., Westerman R., Whiteford H.A., Wilkinson J.D., Wiysonge C.S., Woldeyes B.G., Wolfe C.D.A., Won S., Workicho A., Workie S.B., Wubshet M., Xavier D., Xu G., Yadav A.K., Yaghoubi M., Yakob B., Yan L.L., Yano Y., Yaseri M., Yimam H.H., Yip P., Yonemoto N., Yoon S.-J., Younis M.Z., Yu C., Zaidi Z., El Sayed Zaki M., Zambrana-Torrelio C., Zapata T., Zenebe Z.M., Zodpey S., Zoeckler L., Zuhlke L.J., Murray C.J.L., GBD 2015 Healthcare Access and Quality Collaborators (2017)
      Background National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). ...
    • Immune-based treatment re-challenge in renal cell carcinoma: A systematic review and meta-analysis 

      Papathanassiou M., Tamposis I., Exarchou-Kouveli K.K., Kontou P.I., de Paz A.T., Mitrakas L., Samara M., Bagos P.G., Tzortzis V., Vlachostergios P.J. (2022)
      Introduction: The use of immune checkpoint inhibitors (ICIs) as a front-line treatment for metastatic renal cell carcinoma (RCC) has significantly improved patient’ outcome. However, little is known about the efficacy or ...
    • The response of subgroups of patients with schizophrenia to different antipsychotic drugs: a systematic review and meta-analysis 

      Leucht S., Chaimani A., Krause M., Schneider-Thoma J., Wang D., Dong S., Samara M., Peter N., Huhn M., Priller J., Davis J.M. (2022)
      Background: As comparatively few trials in subgroups of patients with schizophrenia have been done, clinicians need to know whether they can rely on the results of randomised controlled trials (RCTs) in the general population ...
    • Should patients with rheumatic diseases take pain medication in order to engage in exercise? 

      Metsios G.S., Kitas G.D. (2020)
      [No abstract available]
    • Using business process management notation to model therapeutic prescription protocols: The prescit approach 

      Natsiavas P., Stavropoulos T.G., Pliatsios A., Karanikas H., Gavriilidis G.I., Dimitriadis V.K., Nikolaidis G., Nikolopoulos S., Skapinakis P., Thireos E., Kompatsiaris I. (2021)
      Clinical Decision Support Systems (CDSS) could play a prominent role in preventing Adverse Drug Reactions (ADRs) especially when integrated in larger healthcare systems (e.g. Electronic Health Record - EHR systems, Hospital ...