Sfoglia per Soggetto "RNA, Messenger"

Altered DNA methylation pattern characterizes the peripheral immune cells of patients with autoimmune hepatitis

Zachou K., Arvaniti P., Lyberopoulou A., Sevdali E., Speletas M., Ioannou M., Koukoulis G.K., Renaudineau Y., Dalekos G.N. (2022)

Background and Aims: Little is known about the impact of DNA methylation modifications on autoimmune hepatitis (AIH) pathogenesis and therapeutic response. We investigated the potential alterations of DNA methylation in ...

Biochemical and in silico identification of the active site and the catalytic mechanism of the circadian deadenylase HESPERIN

Beta R.A.A., Kyritsis A., Douka V., Papanastasi E., Rizouli M., Leonidas D.D., Vlachakis D., Balatsos N.A.A. (2022)

The 24-h molecular clock is based on the stability of rhythmically expressed transcripts. The shortening of the poly(A) tail of mRNAs is often the first and rate-limiting step that determines the lifespan of a mRNA and is ...

Calcitriol Suppresses HIF-1 and HIF-2 Transcriptional Activity by Reducing HIF-1/2α Protein Levels via a VDR-Independent Mechanism

Gkotinakou I.-M., Kechagia E., Pazaitou-Panayiotou K., Mylonis I., Liakos P., Tsakalof A. (2020)

Hypoxia-inducible transcription factors 1 and 2 (HIFs) are major mediators of cancer development and progression and validated targets for cancer therapy. Although calcitriol, the biologically active metabolite of vitamin ...

Characterizing miRNA–lncRNA Interplay

Karagkouni D., Karavangeli A., Paraskevopoulou M.D., Hatzigeorgiou A.G. (2021)

Long noncoding RNAs (lncRNAs) are noncoding transcripts, usually longer than 200 nt, that constitute one of the largest and significantly heterogeneous RNA families. The annotation of lncRNAs and the characterization of ...

Dexamethasone has a biphasic effect on the c-Jun mRNA expression in the fetal and adult rat lung, in vivo

Kouretas, D.; Taitzoglou, I. (1999)

Glucocorticoids are a very potent therapy for the treatment of asthma as well for lung maturation in the prematurely newborn animals and human. It has been demonstrated that glucocorticoid receptors antagonize the actions ...

DIANA-mirExTra v2.0: Uncovering microRNAs and transcription factors with crucial roles in NGS expression data

Vlachos I.S., Vergoulis T., Paraskevopoulou M.D., Lykokanellos F., Georgakilas G., Georgiou P., Chatzopoulos S., Karagkouni D., Christodoulou F., Dalamagas T., Hatzigeorgiou A.G. (2016)

Differential expression analysis (DEA) is one of the main instruments utilized for revealing molecular mechanisms in pathological and physiological conditions. DIANA-mirExTra v2.0 (http://www.microrna. gr/mirextrav2) ...

Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism

Simopoulou, T.; Malizos, K. N.; Iliopoulos, D.; Stefanou, N.; Papatheodorou, L.; Ioannou, M.; Tsezou, A. (2007)

Objective: To investigate leptin's effect on cartilage metabolism and the pathophysiology of osteoarthritis (OA). Methods: Messenger RNA (mRNA) expression and protein levels of leptin and leptin's receptor isoforms were ...

Dual IRE1 RNase functions dictate glioblastoma development

Lhomond S., Avril T., Dejeans N., Voutetakis K., Doultsinos D., McMahon M., Pineau R., Obacz J., Papadodima O., Jouan F., Bourien H., Logotheti M., Jégou G., Pallares-Lupon N., Schmit K., Le Reste P.-J., Etcheverry A., Mosser J., Barroso K., Vauléon E., Maurel M., Samali A., Patterson J.B., Pluquet O., Hetz C., Quillien V., Chatziioannou A., Chevet E. (2018)

Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ...

The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle

Bori, Z.; Zhao, Z.; Koltai, E.; Fatouros, I. G.; Jamurtas, A. Z.; Douroudos, I. I.; Terzis, G.; Chatzinikolaou, A.; Sovatzidis, A.; Draganidis, D.; Boldogh, I.; Radak, Z. (2012)

Aging results in a significant decline in aerobic capacity and impaired mitochondrial function. We have tested the effects of moderate physical activity on aerobic capacity and a single bout of exercise on the expression ...

Effects of Different Drug Therapies and COVID-19 mRNA Vaccination on Semen Quality in a Man with Ankylosing Spondylitis: A Case Report

Chatzimeletiou K., Fleva A., Sioga A., Georgiou I., Nikolopoulos T.-T., Markopoulou M., Petrogiannis N., Anifandis G., Patrikiou A., Kolibianakis E., Giannakou A., Grimbizis G. (2022)

Background and Objectives: Ankylosing spondylitis (AS) is a condition that affects 0.1% to 0.5% of the adult population. The aim of this case report was to investigate the possible effects of the drugs taken for treatment ...

Effects of Guaiazulene on In Vitro Bovine Embryo Production and on mRNA Transcripts Related to Embryo Quality

Dovolou, E.; Clemente, M.; Amiridis, G. S.; Messinis, I.; Kallitsaris, A.; Gutierrez-Adan, A.; Rizos, D. (2011)

Contents: Reactive oxygen species (ROS) are between the major contributors for the reduced rate of in vitro bovine embryo production. It is believed that they can cause abnormal meiosis of oocytes, developmental arrest or ...

Expression of human serum albumin (HSA) mRNA in human granulosa cells: Potential correlation of the 95 amino acid long carboxyl terminal of HSA to gonadotrophin surge-attenuating factor

Karligiotou, E.; Kollia, P.; Kallitsaris, A.; Messinis, I. E. (2006)

Introduction: According to previous studies, gonadotrophin surge-attenuating factor (GnSAF), which is assumed to be produced in human granulosa cells, has a homology with the carboxyl terminal of the human serum albumin ...

Functional analysis of miRNAs using the DIANA tools online suite

Vlachos I.S., Hatzigeorgiou A.G. (2017)

microRNAs (miRNAs) are central regulators of gene expression. They are actively studied for their involvement in numerous physiological and pathological conditions but also as diagnostic biomarkers or promising therapeutic ...

Hypoxia upregulates integrin gene expression in microvascular endothelial cells and promotes their migration and capillary-like tube formation

Befani C., Liakos P. (2017)

Tissue hypoxia affects gene expression through the hypoxia-inducible transcription factors, HIF-1 and HIF-2, in both physiological and pathological angiogenesis. Angiogenesis is a complex response of endothelial cells ...

Hypoxia-Inducible Factor-2-Altered Urothelial Carcinoma: Clinical and Genomic Features

Vlachostergios P.J., Tamposis I.A., Anagnostou M., Papathanassiou M., Mitrakas L., Zachos I., Thodou E., Samara M., Tzortzis V. (2022)

Background: Hypoxia is recognized as a key feature of cancer growth and is involved in various cellular processes, including proliferation, angiogenesis, and immune surveillance. Besides hypoxia-inducible factor 1-alpha ...

Immunogenicity of the BNT162b2 mRNA Covid-19 vaccine in elderly people over 85 years of age in Greece: the GREVAXIMO study

Kontopoulou K., Nakas C.T., Ainatzoglou A., Ifantidou A., Ntotsi P., Katsioulis C., Papazisis G. (2021)

Background: Elderly people aged over 85 years were among the first groups to receive the BNT162b2 mRNA Covid-19 vaccine in Greece according to the national priority assignment policy. Aim: The aim of this study was to ...