Όλο το DSpace

Πλοήγηση ανά Θέμα "Parkinson disease"

Αποτελέσματα 1-20 από 73

    • Activation of FADD-Dependent neuronal death pathways as a predictor of pathogenicity for LRRK2 mutations 

      Melachroinou K., Leandrou E., Valkimadi P.-E., Memou A., Hadjigeorgiou G., Stefanis L., Rideout H.J. (2016)
      Background Despite the plethora of sequence variants in LRRK2, only a few clearly segregate with PD. Even within this group of pathogenic mutations, the phenotypic profile can differ widely. Objective We examined multiple ...

    • ADORA2A rS5760423 and CYP1A2 rs762551 polymorphisms as risk factors for parkinson’s disease 

      Siokas V., Aloizou A.-M., Tsouris Z., Liampas I., Liakos P., Calina D., Docea A.O., Tsatsakis A., Bogdanos D.P., Hadjigeorgiou G.M., Dardiotis E. (2021)
      Background: Parkinson’s disease (PD) is the second commonest neurodegenerative disease. The genetic basis of PD is indisputable. Both ADORA2A rs5760423 and CYP1A2 rs762551 have been linked to PD, to some extent, but the ...

    • Alpha-synuclein repeat variants and survival in parkinson's disease 

      Chung, S. J.; Biernacka, J. M.; Armasu, S. M.; Anderson, K.; Frigerio, R.; Aasly, J. O.; Annesi, G.; Bentivoglio, A. R.; Brighina, L.; Chartier-Harlin, M. C.; Goldwurm, S.; Hadjigeorgiou, G.; Jasinska-Myga, B.; Jeon, B. S.; Kim, Y. J.; Krüger, R.; Lesage, S.; Markopoulou, K.; Mellick, G.; Morrison, K. E.; Puschmann, A.; Tan, E. K.; Crosiers, D.; Theuns, J.; Van Broeckhoven, C.; Wirdefeldt, K.; Wszolek, Z. K.; Elbaz, A.; Maraganore, D. M.; Yahalom, G.; Orlev, Y.; Cohen, O. S.; Kozlova, E.; Friedman, E.; Inzelberg, R.; Hassin-Baer, S. (2014)
      Objectives: To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease ...

    • Applications of nanotechnology in diagnostics and therapeutics of Alzheimer's and Parkinson's disease 

      Soursou G., Alexiou A., Ashraf G.M., Siyal A.A., Mushtaq G., Kamal M.A. (2015)
      In this paper, an extended review analysis has been presented concerning the developments in brain drug delivery through new and efficient applications of nanotechnology. Modern nanotechnological approaches for the diagnosis ...

    • Assessment of TREM2 rs75932628 variant’s association with Parkinson’s disease in a Greek population and Meta-analysis of current data 

      Dardiotis E., Rikos D., Siokas V., Aloizou A.-M., Tsouris Z., Sakalakis E., Brotis A.G., Bogdanos D.P., Hadjigeorgiou G.M. (2021)
      Background: Α number of genetic variants are considered to confer susceptibility to Parkinson’s disease (PD). Rs75392628 (R47H), a rare variant of TREM2 gene, has been linked to PD, although its role on PD remains conflicting. ...

    • Association between Motor Signs and Cognitive Performance in Cognitively Unimpaired Older Adults: A Cross-Sectional Study Using the NACC Database 

      Siokas V., Liampas I., Lyketsos C.G., Dardiotis E. (2022)
      Aiming to examine whether specific motor signs are associated with worse performance in specific cognitive domains among cognitively unimpaired (CU) individuals, we performed a cross-sectional analysis of data from the ...

    • Association between white matter lesions and Parkinson’s disease: an impact on Postural/Gait difficulty phenotype and cognitive performance 

      Sinani O., Dadouli K., Ntellas P., Kapsalaki E.Z., Vlychou M., Raptis D.G., Marogianni C., Markou K., Dardiotis E., Xiromerisiou G. (2022)
      Background: White matter hyperintensities (WMHs) may be observed on Magnetic Resonance Imaging (MRI) in patients with Parkinson disease with or without vascular risk factors. Whether WMHs may influence motor and non-motor ...

    • Association of the Polygenic Risk Score With the Probability of Prodromal Parkinson’s Disease in Older Adults 

      Maraki M.I., Hatzimanolis A., Mourtzi N., Stefanis L., Yannakoulia M., Kosmidis M.H., Dardiotis E., Hadjigeorgiou G.M., Sakka P., Ramirez A., Grenier-Boley B., Lambert J.-C., Heilmann-Heimbach S., Stamelou M., Scarmeas N., Xiromerisiou G. (2021)
      Several studies have investigated the association of the Parkinson’s disease (PD) polygenic risk score (PRS) with several aspects of well-established PD. We sought to evaluate the association of PRS with the prodromal stage ...

    • Association of α-synuclein Rep1 polymorphism and Parkinson's disease: Influence of Rep1 on age at onset 

      Hadjigeorgiou, G. H.; Xiromerisiou, G.; Gourbali, V.; Aggelakis, K.; Scarmeas, N.; Papadimitriou, A.; Singleton, A. (2006)
      The α-synuclein Rep1 polymorphism was studied in patients and controls in an ethnic Greek population. There was an association of allele 2 with risk of Parkinson's disease (PD; adjusted odd ratio = 3.25; 95% CI = 1.80-5.87). ...

    • The beneficial effects of computer-based cognitive training in parkinson's disease: A systematic review 

      Nousia A., Martzoukou M., Tsouris Z., Siokas V., Aloizou A.-M., Liampas I., Nasios G., Dardiotis E. (2021)
      Background: Cognitive dysfunction is one of the most prevalent non-motor aspects of Parkinson's disease (PD). The present review focuses on published studies investigating the effect of computer-based cognitive training ...

    • CD33 rs3865444 as a risk factor for Parkinson's disease 

      Siokas V., Arseniou S., Aloizou A.-M., Tsouris Z., Liampas I., Sgantzos M., Liakos P., Bogdanos D.P., Hadjigeorgiou G.M., Dardiotis E. (2021)
      Background: Alzheimer's (AD) and Parkinson's diseases (PD) share a few elements of their clinical, pathological and genetic backgrounds. The CD33 rs3865444 has emerged as a strong genetic locus associated with AD through ...

    • Clinical phenotype in patients with α-synuclein Parkinson's disease living in Greece in comparison with patients with sporadic Parkinson's disease 

      Papapetropoulos, S.; Paschalis, C.; Athanassiadou, A.; Papadimitriou, A.; Ellul, J.; Polymeropoulos, M. H.; Papapetropoulos, Th (2001)
      Objective - An Ala53Thr mutation of the α-synuclein gene has been recently identified as a rare cause of autosomal Parkinson's disease (PD). The clinical characteristics of 15 patients with PD living in Greece with the ...

    • Clinically meaningful parameters of progression and long-term outcome of Parkinson disease: AN international consensus statement 

      Puschmann, A.; Brighina, L.; Markopoulou, K.; Aasly, J.; Chung, S. J.; Frigerio, R.; Hadjigeorgiou, G.; Kõks, S.; Krüger, R.; Siuda, J.; Wider, C.; Zesiewicz, T. A.; Maraganore, D. M. (2015)
      Parkinson disease (PD) is associated with a clinical course of variable duration, severity, and a combination of motor and non-motor features. Recent PD research has focused primarily on etiology rather than clinical ...

    • Construction of joint confidence regions for the optimal true class fractions of Receiver Operating Characteristic (ROC) surfaces and manifolds 

      Bantis L.E., Nakas C.T., Reiser B., Myall D., Dalrymple-Alford J.C. (2017)
      The three-class approach is used for progressive disorders when clinicians and researchers want to diagnose or classify subjects as members of one of three ordered categories based on a continuous diagnostic marker. The ...

    • Correlation of Neuropsychiatric Symptoms in Dementia with Brain Perfu-sion: A 99mTc-SPECT-HMPAO Study with Brodmann Areas Analysis 

      Valotassiou V., Sifakis N., Tzavara C., Lykou E., Tsinia N., Kamtsadeli V., Sali D., Angelidis G., Psimadas D., Tsougos I., Papageorgiou S.G., Georgoulias P., Papatriantafyllou J. (2021)
      Background: Neuropsychiatric symptoms (NPSs) are common in dementia. Their evaluation is based on Neuropsychiatric Inventory (NPI). Neuroimaging studies have tried to elucidate the underlying neural circuits either in ...

    • Current evidence on the effect of dietary polyphenols intake on chronic diseases 

      Costa C., Tsatsakis A., Mamoulakis C., Teodoro M., Briguglio G., Caruso E., Tsoukalas D., Margina D., Dardiotis E., Kouretas D., Fenga C. (2017)
      Polyphenols are secondary metabolites of plants. They comprise several antioxidant compounds and they are generally considered to be involved in the defense against human chronic diseases. During the last years, there has ...

    • CYP1A2 rs762551 and ADORA2A rs5760423 Polymorphisms in Patients with Blepharospasm 

      Siokas V., Kardaras D., Aloizou A.-M., Liampas I., Papageorgiou E., Drakoulis N., Tsatsakis A., Mitsias P.D., Hadjigeorgiou G.M., Tsironi E.E., Dardiotis E. (2020)
      Blepharospasm (BSP) is a neurological movement disorder. Coffee consumption has been found to have a protective effect against BSP. BSP and apraxia of eyelid opening are particularly common among patients with PD. The ...

    • Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study 

      Domenighetti C., Sugier P.-E., Ashok Kumar Sreelatha A., Schulte C., Grover S., Mohamed O., Portugal B., May P., Bobbili D.R., Radivojkov-Blagojevic M., Lichtner P., Singleton A.B., Hernandez D.G., Edsall C., Mellick G.D., Zimprich A., Pirker W., Rogaeva E., Lang A.E., Koks S., Taba P., Lesage S., Brice A., Corvol J.-C., Chartier-Harlin M.-C., Mutez E., Brockmann K., Deutschländer A.B., Hadjigeorgiou G.M., Dardiotis E., Stefanis L., Simitsi A.M., Valente E.M., Petrucci S., Duga S., Straniero L., Zecchinelli A., Pezzoli G., Brighina L., Ferrarese C., Annesi G., Quattrone A., Gagliardi M., Matsuo H., Kawamura Y., Hattori N., Nishioka K., Chung S.J., Kim Y.J., Kolber P., van de Warrenburg B.P.C., Bloem B.R., Aasly J., Toft M., Pihlstrøm L., Correia Guedes L., Ferreira J.J., Bardien S., Carr J., Tolosa E., Ezquerra M., Pastor P., Diez-Fairen M., Wirdefeldt K., Pedersen N.L., Ran C., Belin A.C., Puschmann A., Hellberg C., Clarke C.E., Morrison K.E., Tan M., Krainc D., Burbulla L.F., Farrer M.J., Krüger R., Gasser T., Sharma M., Elbaz A., and the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium (2022)
      Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or ...

    • Dementia incidence in the elderly population of greece: Results from the HELIAD study 

      Vlachos G.S., Kosmidis M.H., Yannakoulia M., Dardiotis E., Hadjigeorgiou G., Tzoulaki I., Georgiou A.N., Sakka P., Anastasiou C.A., Stefanis L., Scarmeas N. (2021)
      Objectives:Recently a declining trend in dementia incidence rates has been reported in high-income countries. We investigated dementia incidence in a representative sample of the Greek population in the age group of 65 ...

    • Dietary Inflammatory Index score and prodromal Parkinson's disease incidence: The HELIAD study 

      Balomenos V., Bounou L., Charisis S., Stamelou M., Ntanasi E., Georgiadi K., Mourtzinos I., Tzima K., Anastasiou C.A., Xiromerisiou G., Maraki M., Yannakoulia M., Kosmidis M.H., Dardiotis E., Hadjigeorgiou G., Sakka P., Stefanis L., Scarmeas N. (2022)
      The aim of the present study was to investigate the association of the inflammatory potential of diet with prodromal Parkinson's disease (pPD) probability and incidence among community-dwelling older individuals without ...