Όλο το DSpace

Πλοήγηση ανά Θέμα "Nature Publishing Group"

Αποτελέσματα 1-20 από 32

    • Age, sex, adult and larval diet shape starvation resistance in the Mediterranean fruit fly: an ecological and gerontological perspective 

      Gerofotis C.D., Kouloussis N.A., Koukougiannidou C., Papadopoulos N.T., Damos P., Koveos D.S., Carey J.R. (2019)
      The ability of an animal to withstand periods of food deprivation is a key driver of invasion success (biodiversity), adaptation to new conditions, and a crucial determinant of senescence in populations. Starvation resistance ...

    • AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders 

      Salpietro V., Dixon C.L., Guo H., Bello O.D., Vandrovcova J., Efthymiou S., Maroofian R., Heimer G., Burglen L., Valence S., Torti E., Hacke M., Rankin J., Tariq H., Colin E., Procaccio V., Striano P., Mankad K., Lieb A., Chen S., Pisani L., Bettencourt C., Männikkö R., Manole A., Brusco A., Grosso E., Ferrero G.B., Armstrong-Moron J., Gueden S., Bar-Yosef O., Tzadok M., Monaghan K.G., Santiago-Sim T., Person R.E., Cho M.T., Willaert R., Yoo Y., Chae J.-H., Quan Y., Wu H., Wang T., Bernier R.A., Xia K., Blesson A., Jain M., Motazacker M.M., Jaeger B., Schneider A.L., Boysen K., Muir A.M., Myers C.T., Gavrilova R.H., Gunderson L., Schultz-Rogers L., Klee E.W., Dyment D., Osmond M., Parellada M., Llorente C., Gonzalez-Peñas J., Carracedo A., Van Haeringen A., Ruivenkamp C., Nava C., Heron D., Nardello R., Iacomino M., Minetti C., Skabar A., Fabretto A., Hanna M.G., Bugiardini E., Hostettler I., O’Callaghan B., Khan A., Cortese A., O’Connor E., Yau W.Y., Bourinaris T., Kaiyrzhanov R., Chelban V., Madej M., Diana M.C., Vari M.S., Pedemonte M., Bruno C., Balagura G., Scala M., Fiorillo C., Nobili L., Malintan N.T., Zanetti M.N., Krishnakumar S.S., Lignani G., Jepson J.E.C., Broda P., Baldassari S., Rossi P., Fruscione F., Madia F., Traverso M., De-Marco P., Pérez-Dueñas B., Munell F., Kriouile Y., El-Khorassani M., Karashova B., Avdjieva D., Kathom H., Tincheva R., Van-Maldergem L., Nachbauer W., Boesch S., Gagliano A., Amadori E., Goraya J.S., Sultan T., Kirmani S., Ibrahim S., Jan F., Mine J., Banu S., Veggiotti P., Zuccotti G.V., Ferrari M.D., Van Den Maagdenberg A.M.J., Verrotti A., Marseglia G.L., Savasta S., Soler M.A., Scuderi C., Borgione E., Chimenz R., Gitto E., Dipasquale V., Sallemi A., Fusco M., Cuppari C., Cutrupi M.C., Ruggieri M., Cama A., Capra V., Mencacci N.E., Boles R., Gupta N., Kabra M., Papacostas S., Zamba-Papanicolaou E., Dardiotis E., Maqbool S., Rana N., Atawneh O., Lim S.Y., Shaikh F., Koutsis G., Breza M., Coviello D.A., Dauvilliers Y.A., AlKhawaja I., AlKhawaja M., Al-Mutairi F., Stojkovic T., Ferrucci V., Zollo M., Alkuraya F.S., Kinali M., Sherifa H., Benrhouma H., Turki I.B.Y., Tazir M., Obeid M., Bakhtadze S., Saadi N.W., Zaki M.S., Triki C.C., Benfenati F., Gustincich S., Kara M., Belcastro V., Specchio N., Capovilla G., Karimiani E.G., Salih A.M., Okubadejo N.U., Ojo O.O., Oshinaike O.O., Oguntunde O., Wahab K., Bello A.H., Abubakar S., Obiabo Y., Nwazor E., Ekenze O., Williams U., Iyagba A., Taiwo L., Komolafe M., Senkevich K., Shashkin C., Zharkynbekova N., Koneyev K., Manizha G., Isrofilov M., Guliyeva U., Salayev K., Khachatryan S., Rossi S., Silvestri G., Haridy N., Ramenghi L.A., Xiromerisiou G., David E., Aguennouz M., Fidani L., Spanaki C., Tucci A., Raspall-Chaure M., Chez M., Tsai A., Fassi E., Shinawi M., Constantino J.N., De Zorzi R., Fortuna S., Kok F., Keren B., Bonneau D., Choi M., Benzeev B., Zara F., Mefford H.C., Scheffer I.E., Clayton-Smith J., Macaya A., Rothman J.E., Eichler E.E., Kullmann D.M., Houlden H., SYNAPS Study Group (2019)
      AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at ...

    • Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways 

      Yiallouris A., Patrikios I., Johnson E.O., Sereti E., Dimas K., De Ford C., Fedosova N.U., Graier W.F., Sokratous K., Kyriakou K., Stephanou A. (2018)
      In the healthcare sector, phytocompounds are known to be beneficial by contributing or alleviating a variety of diseases. Studies have demonstrated the progressive effects of phytocompounds on immune-related diseases and ...

    • Author Correction: A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis (Nature Communications, (2019), 10, 1, (2236), 10.1038/s41467-019-09773-y) 

      Madireddy L., Patsopoulos N.A., Cotsapas C., Bos S.D., Beecham A., McCauley J., Kim K., Jia X., Santaniello A., Caillier S.J., Andlauer T.F.M., Barcellos L.F., Berge T., Bernardinelli L., Martinelli-Boneschi F., Booth D.R., Briggs F., Celius E.G., Comabella M., Comi G., Cree B.A.C., D’Alfonso S., Dedham K., Duquette P., Dardiotis E., Esposito F., Fontaine B., Gasperi C., Goris A., Dubois B., Gourraud P.-A., Hadjigeorgiou G., Haines J., Hawkins C., Hemmer B., Hintzen R., Horakova D., Isobe N., Kalra S., Kira J.-I., Khalil M., Kockum I., Lill C.M., Lincoln M.R., Luessi F., Martin R., Oturai A., Palotie A., Pericak-Vance M.A., Henry R., Saarela J., Ivinson A., Olsson T., Taylor B.V., Stewart G.J., Harbo H.F., Compston A., Hauser S.L., Hafler D.A., Zipp F., De Jager P., Sawcer S., Oksenberg J.R., Baranzini S.E., International Multiple Sclerosis Genetics Consortium (2019)
      The original version of this Article contained an error in the spelling of the author Nikolaos A. Patsopoulos, which was incorrectly given as Niklaos A. Patsopoulos, and author Efthimios Dardiotis, which was incorrectly ...

    • Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus 

      Medina-Gomez C., Kemp J.P., Dimou N.L., Kreiner E., Chesi A., Zemel B.S., Bønnelykke K., Boer C.G., Ahluwalia T.S., Bisgaard H., Evangelou E., Heppe D.H.M., Bonewald L.F., Gorski J.P., Ghanbari M., Demissie S., Duque G., Maurano M.T., Kiel D.P., Hsu Y.-H., Van Der Eerden B.C.J., Ackert-Bicknell C., Reppe S., Gautvik K.M., Raastad T., Karasik D., Van De Peppel J., Jaddoe V.W.V., Uitterlinden A.G., Tobias J.H., Grant S.F.A., Bagos P.G., Evans D.M., Rivadeneira F. (2017)
      Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS ...

    • Checking for voice disorders without clinical intervention: The Greek and global VHI thresholds for voice disordered patients 

      Tafiadis D., Chronopoulos S.K., Helidoni M.E., Kosma E.I., Voniati L., Papadopoulos P., Murry T., Ziavra N., Velegrakis G.A. (2019)
      Voice disorders often remain undiagnosed. Many self-perceived questionnaires exist for various medical conditions. Here, we used the Greek Voice Handicap Index (VHI) to address the aforementioned problem. Everyone can fill ...

    • Circulating biomarkers for cardiovascular diseases: The beats never stop editorial 

      Xi L., Kouvelos G., Paolocci N. (2018)
      [No abstract available]

    • Data driven inference for the repulsive exponent of the Lennard-Jones potential in molecular dynamics simulations 

      Kulakova L., Arampatzis G., Angelikopoulos P., Hadjidoukas P., Papadimitriou C., Koumoutsakos P. (2017)
      The Lennard-Jones (LJ) potential is a cornerstone of Molecular Dynamics (MD) simulations and among the most widely used computational kernels in science. The LJ potential models atomistic attraction and repulsion with ...

    • Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform 

      Gkretsi V., Kalli M., Efstathiades C., Papageorgis P., Papanikolaou V., Zacharia L.C., Tsezou A., Athanassiou E., Stylianopoulos T. (2019)
      Extracellular matrix (ECM)-adhesion proteins and actin cytoskeleton are pivotal in cancer cell invasion. Ras Suppressor-1 (RSU-1), a cell-ECM adhesion protein that interacts with PINCH-1, thus being connected to Integrin ...

    • Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells article 

      Krishnamoorthy J., Tenkerian C., Gupta J., Ghaddar N., Wang S., Darini C., Staschke K.A., Ghosh A., Gandin V., Topisirovic I., Kristof A.S., Hatzoglou M., Simos G., Koromilas A.E. (2018)
      Oxidative stress determines cell fate through several mechanisms, among which regulation of mRNA translation by the phosphorylation of the alpha (α) subunit of the translation initiation factor eIF2α at serine 51 (eIF2αP) ...

    • The effect of vitamin B12 and folic acid supplementation on routine haematological parameters in older people: An individual participant data meta-Analysis 

      Smelt A.F., Gussekloo J., Bermingham L.W., Allen E., Dangour A.D., Eussen S.J., Favrat B., De Groot L.C., Kok F.J., Kwok T., Mangoni A.A., Ntaios G., Van De Rest O., Seal E., Vaucher P., Verhoef P., Stijnen T., Den Elzen W.P. (2018)
      Background/objectives: Low vitamin B12 and folate levels in community-dwelling older people are usually corrected with supplements. However, the effect of this supplementation on haematological parameters in older persons ...

    • Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia 

      Hackinger S., Prins B., Mamakou V., Zengini E., Marouli E., Brčić L., Serafetinidis I., Lamnissou K., Kontaxakis V., Dedoussis G., Gonidakis F., Thanopoulou A., Tentolouris N., Tsezou A., Zeggini E. (2018)
      The epidemiologic link between schizophrenia (SCZ) and type 2 diabetes (T2D) remains poorly understood. Here, we investigate the presence and extent of a shared genetic background between SCZ and T2D using genome-wide ...

    • FCGR3A-V158F polymorphism is a disease-specific pharmacogenetic marker for the treatment of psoriasis with Fc-containing TNFα inhibitors 

      Mendrinou E., Patsatsi A., Zafiriou E., Papadopoulou D., Aggelou L., Sarri C., Mamuris Z., Kyriakou A., Sotiriadis D., Roussaki-Schulze A., Sarafidou T., Vasilopoulos Y. (2017)
      Psoriasis is a multifactorial skin disease affecting ∼2% of world's population, causing a dramatic decrease in patients' quality of life and a significant increase in health-care expenses. Biological agents such as the ...

    • Gene expression profiling of microbial activities and interactions in sediments under haloclines of E. Mediterranean deep hypersaline anoxic basins 

      Edgcomb V.P., Pachiadaki M.G., Mara P., Kormas K.A., Leadbetter E.R., Bernhard J.M. (2016)
      Deep-sea hypersaline anoxic basins (DHABs) in the Eastern Mediterranean Sea are considered some of the most polyextreme habitats on Earth. In comparison to microbial activities occurring within the haloclines and brines ...

    • Genomics of habitat choice and adaptive evolution in a deep-sea fish 

      Gaither M.R., Gkafas G.A., De Jong M., Sarigol F., Neat F., Regnier T., Moore D., Gröcke D.R., Hall N., Liu X., Kenny J., Lucaci A., Hughes M., Haldenby S., Hoelzel A.R. (2018)
      Intraspecific diversity promotes evolutionary change, and when partitioned among geographic regions or habitats can form the basis for speciation. Marine species live in an environment that can provide as much scope for ...

    • Helicobacter pylori Infection and Gastroesophageal Reflux Disease–Barrett’s Esophagus–Esophageal Adenocarcinoma Sequence 

      Kountouras J., Doulberis M., Polyzos S.A., Zeglinas C., Vardaka E., Kountouras C., Tzivras D., Dardiotis E., Exadaktylos A., Katsinelos P. (2018)
      [No abstract available]

    • Housekeeping in Tephritid insects: The best gene choice for expression analyses in the medfly and the olive fly 

      Sagri E., Koskinioti P., Gregoriou M.-E., Tsoumani K.T., Bassiakos Y.C., Mathiopoulos K.D. (2017)
      Real-time quantitative-PCR has been a priceless tool for gene expression analyses. The reaction, however, needs proper normalization with the use of housekeeping genes (HKGs), whose expression remains stable throughout the ...

    • Immune responses against Helicobacter pylori-specific antigens differentiate relapsing remitting from secondary progressive multiple sclerosis 

      Efthymiou G., Dardiotis E., Liaskos C., Marou E., Tsimourtou V., Rigopoulou E.I., Scheper T., Daponte A., Meyer W., Sakkas L.I., Hadjigeorgiou G., Bogdanos D.P. (2017)
      To assess whether Helicobacter pylori (Hp) antibody (ab) reactivity against individual Hp antigens is pathogenetically relevant to multiple sclerosis (MS), we systematically investigated prevalence and clinical significance ...

    • A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants 

      Fritsche L.G., Igl W., Bailey J.N.C., Grassmann F., Sengupta S., Bragg-Gresham J.L., Burdon K.P., Hebbring S.J., Wen C., Gorski M., Kim I.K., Cho D., Zack D., Souied E., Scholl H.P.N., Bala E., ELee K., Hunter D.J., Sardell R.J., Mitchell P., Merriam J.E., Cipriani V., Hoffman J.D., Schick T., Lechanteur Y.T.E., Guymer R.H., Johnson M.P., Jiang Y., Stanton C.M., Buitendijk G.H.S., Zhan X., Kwong A.M., Boleda A., Brooks M., Gieser L., Ratnapriya R., Branham K.E., Foerster J.R., Heckenlively J.R., Othman M.I., Vote B.J., Liang H.H., Souzeau E., McAllister I.L., Isaacs T., Hall J., Lake S., Mackey D.A., Constable I.J., Craig J.E., Kitchner T.E., Yang Z., Su Z., Luo H., Chen D., Ouyang H., Flagg K., Lin D., Mao G., Ferreyra H., Stark K., Von Strachwitz C.N., Wolf A., Brandl C., Rudolph G., Olden M., Morrison M.A., Morgan D.J., Schu M., Ahn J., Silvestri G., Tsironi E.E., Park K.H., Farrer L.A., Orlin A., Brucker A., Li M., Curcio C.A., Mohand-Sa'd S., Sahel J.-A., Audo I., Benchaboune M., Cree A.J., Rennie C.A., Goverdhan S.V., Grunin M., Hagbi-Levi S., Campochiaro P., Katsanis N., Holz F.G., Blond F., Blanché H., Deleuze J.-F., Igo R.P., Jr., Truitt B., Peachey N.S., Meuer S.M., Myers C.E., Moore E.L., Klein R., Hauser M.A., Postel E.A., Courtenay M.D., Schwartz S.G., Kovach J.L., Scott W.K., Liew G., Tan A.G., Gopinath B., Merriam J.C., Smith R.T., Khan J.C., Shahid H., Moore A.T., McGrath J.A., Laux R., Brantley M.A., Jr., Agarwal A., Ersoy L., Caramoy A., Langmann T., Saksens N.T.M., Jong E.K., Hoyng C.B., Cain M.S., Richardson A.J., Martin T.M., Blangero J., Weeks D.E., Dhillon B., Van Duijn C.M., Doheny K.F., Romm J., Klaver C.C.W., Hayward C., Gorin M.B., Klein M.L., Baird P.N., Den Hollander A.I., Fauser S., WYates J.R., Allikmets R., Wang J.J., Schaumberg D.A., Klein B.E.K., Hagstrom S.A., Chowers I., Lotery A.J., Léveillard T., Zhang K., Brilliant M.H., Hewitt A.W., Swaroop A., Chew E.Y., Pericak-Vance M.A., DeAngelis M., Stambolian D., Haines J.L., Iyengar S.K., Weber B.H.F., Abecasis G.R., Heid I.M. (2016)
      Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, with limited therapeutic options. Here we report on a study of >12 million variants, including 163,714 directly genotyped, ...

    • Major hepatic complications in ursodeoxycholic acid-treated patients with primary biliary cholangitis: Risk factors and time trends in incidence and outcome 

      Harms M.H., Lammers W.J., Thorburn D., Corpechot C., Invernizzi P., Janssen H.L.A., Battezzati P.M., Nevens F., Lindor K.D., Floreani A., Ponsioen C.Y., Mayo M.J., Dalekos G.N., Bruns T., Parés A., Mason A.L., Verhelst X., Kowdley K.V., Goet J.C., Hirschfield G.M., Hansen B.E., Van Buuren H.R. (2018)
      Objectives: In this era of near universal ursodeoxycholic acid (UDCA) treatment for primary biliary cholangitis (PBC), progression to cirrhosis still occurs in an important proportion of patients. The aim of this study was ...