Πλοήγηση ανά Θέμα "MECHANISM"

Branched-chain C-cyano pyranonucleosides: Synthesis of 3 '-C-cyano & 3 '-C-cyano-3 '-deoxy pyrimidine pyranonucleosides as novel cytotoxic agents

Kiritsis, C.; Manta, S.; Parmenopoulou, V.; Balzarini, J.; Komiotis, D. (2011)

This report describes the total and facile synthesis of 3'-C-cyano & 3'-C-cyano-3'-deoxy pyrimidine pyranonucleosides. Reaction of 3-keto glucoside 1 with sodium cyanide gave the desired precursor 3-C-cyano-1,2:5,6-di-O- ...

Calcium carbonate scaling in a plate heat exchanger in the presence of particles

Andritsos, N.; Karabelas, A. J. (2003)

Scale formation of CaCO3 in a plate heat exchanger is investigated in the presence of various types of added particles under isothermal conditions. The parameters examined include the degree of supersaturation, the type ...

Catch the kinase conformer

McInnes, C.; Mezna, M.; Kontopidis, G. (2006)

Protein kinases exist in inactive and active states, but little attention has been paid to which state is or should be the target in drug discovery efforts. In this issue of Chemistry & Biology, Okram et al. [1] tackle ...

Cell-free plasma DNA as a novel marker of aseptic inflammation severity related to exercise overtraining

Fatouros, I. G.; Destouni, A.; Margonis, K.; Jamurtas, A. Z.; VrettoU, C.; Kouretas, D.; Mastorakos, G.; MitrakoU, A.; Taxildaris, K.; Kanavakis, E.; Papassotiriou, I. (2006)

Background: Circulating free plasma DNA is implicated in conditions associated with tissue injury, including exercise-induced inflammation, and thus is a potential marker for athletic overtraining. Methods: We measured ...

A concise synthesis of 3-fluoro-5-thio-xylo- and glucopyranoses, useful precursors towards their corresponding pyranonucleoside derivatives

Tsoukala, E.; Manta, S.; Tzioumaki, N.; Agelis, G.; Komiotis, D. (2008)

The chemical synthesis of 1,2,4-tri-O-acetyl-3-deoxy-3-fluoro-5-thio-D-xylopyranose, 1,2,4,6-tetra-O-acetyl-3-deoxy-3 -fluoro-5-thio-alpha(-D-glucopyranose and their corresponding nucleosides of thymine is described. ...

Correlation between recombination junctions and RNA secondary structure elements in poliovirus Sabin strains

Dedepsidis, E.; Kyriakopoulou, Z.; Pliaka, V.; Markoulatos, P. (2010)

In order to test the hypothesis that RNA structural elements promote the distribution of certain types of recombination junctions in each one of the 2C and 3D poliovirus genomic regions (Sabin 3/Sabin 2 or Sabin 1 in 2C ...

Detection of microsatellite instability in sporadic cardiac myxomas

Sourvinos, G.; Parissis, J.; Sotsiou, F.; Arvanitis, D. L.; Spandidos, D. A. (1999)

Objective: Microsatellite instability (MIN) is an early event in DNA repair-deficient associated diseases and reflects an elevated mutation rate in the genome of neoplastic cells. Sporadic cardiac myxomas are the most ...

Direct ethanol fuel cells: The effect of the cell discharge current on the products distribution

Andreadis, G.; Stergiopoulos, V.; Song, S.; Tsiakaras, P. (2010)

In the present work the results of the continuous and on-line product analysis during a Direct Ethanol Polymer Electrolyte Membrane Fuel Cell operation (DE-PEMFC) are presented. The effect of both cell discharge current ...

Effect of channel width on the primary instability of inclined film flow

Vlachogiannis, M.; Samandas, A.; Leontidis, V.; Bontozoglou, V. (2010)

A procedure is developed to detect the onset of interfacial instability in inclined film flows (with estimated accuracy better than 5%) and is used to show that the finite width of experimental channels stabilizes the ...

Effects of pulsed electric fields on DNA of human lymphocytes

Delimaris, J.; Tsilimigaki, S.; Messini-Nicolaki, N.; Ziros, E.; Piperakis, S. M. (2006)

The effects of pulsed electric fields of low frequency (50 Hz) on DNA of human lymphocytes were investigated. The influence of additional external factors, such as hydrogen peroxide (H2O2) and gamma-irradiation, as well ...

Effects of the Val211Gly substitution on molecular dynamics of the CMY-2 cephalosporinase: Implications on hydrolysis of expanded-spectrum cephalosporins

Kotsakis, S. D.; Tzouvelekis, L. S.; Petinaki, E.; Tzelepi, E.; Miriagou, V. (2011)

CMY-30, a naturally occurring class C beta-lactamase differing from the Citrobacter freundii-derived CMY-2 by a Val211Gly substitution in the X-loop, exhibits increased hydrolytic efficiency against ceftazidime and cefotaxime. ...

Enzymatic oxidation of vanillin, isovanillin and protocatechuic aldehyde with freshly prepared guinea pig liver slices

Panoutsopoulos, G. I.; Beedham, C. (2005)

Background/ Aims: The oxidation of xenobiotic- derived aromatic aldehydes with freshly prepared liver slices has not been previously reported. The present investigation compares the relative contribution of aldehyde oxidase, ...

An EPR study of Cu adsorption by clinoptilolite from Cl-, NO3 and SO42- solutions

Doula, M. K.; Dimirkou, A. (2008)

The concentration and the type of Cu2+ species adsorbed on a natural zeolite (Clinoptilolite) was measured and studied by using Electron Paramagnetic Resonance Spectroscopy (EPR). The EPR results together with macroscopic ...

An evolutionary theory based on a protein-mRNA co-synthesis hypothesis

Gounaris, Y. (2011)

A new hypothesis is proposed, that early life possessed a mechanism for the simultaneous synthesis of a polypeptide and its coding mRNA. Early tRNAs and mRNAs are considered to have been pairs of simple complementary ...

Extrachromosomal genetic elements detected in Escherichia coli treated with the antibacterial agents kanamycin and benzenetriol

Gounaris, Y. (2013)

Resistance to kanamycin was induced in Escherichia coli cells subjected to gradually increasing concentrations of the amino glycoside antibiotic kanamycin. The frequency of the appearance of resistance is not in agreement ...