Πλοήγηση ανά Θέμα "DNA polymorphism"

Association of ITPA gene polymorphisms with adverse effects of AZA/6-MP administration: a systematic review and meta-analysis

Barba E., Kontou P.I., Michalopoulos I., Bagos P.G., Braliou G.G. (2022)

Azathioprine (AZA) and its metabolite, mercaptopurine (6-MP), are widely used immunosuppressant drugs. Polymorphisms in genes implicated in AZA/6-MP metabolism, reportedly, could account in part for their potential toxicity. ...

Association of maternal Toll-like receptor-4 alleles with susceptibility to early-onset preeclampsia in central Greece

Vamvakopoulou D.N., Satra M., Fegga A., Kourti M., Sidiropoulos A., Daponte A., Gounaris A., Syrogianopoulos G., Vamvakopoulos N.C., Sotiriou S. (2019)

Introduction: Altered maternal inflammatory responses may play a role in the development of hypertensive disorders of pregnancy like preeclampsia, its more severe early-onset form and intrauterine growth restriction. We ...

Association of p16 (CDKN2A) polymorphisms with the development of HPV16-related precancerous lesions and cervical cancer in the Greek population

Tsakogiannis D., Moschonas G.D., Bella E., Kyriakopoulou Z., Amoutzias G.D., Dimitriou T.G., Kottaridi C., Markoulatos P. (2018)

The tumor suppressor protein p16 plays a fundamental role in cell cycle regulation and exerts a protective effect against tumor growth. Two different polymorphisms at positions 540 and 580 at the 3′UTR of exon 3 of p16 ...

BAFF receptor polymorphisms and deficiency in humans

Sevdali E., Block Saldana V., Speletas M., Eibel H. (2021)

The BAFF-receptor (BAFFR) is a member of the TNF-receptor family. It is expressed only by B cells and binds BAFF as single ligand, which activates key signaling pathways regulating essential cellular functions, including ...

Circulating biomarkers for the prediction of abdominal aortic aneurysm growth

Nana P., Dakis K., Brodis A., Spanos K., Kouvelos G. (2021)

Background: Abdominal aortic aneurysm represents a distinct group of vascular lesions, in terms of surveillance and treatment. Screening and follow-up of patients via duplex ultrasound has been well established and proposed ...

CYP1A2 rs762551 polymorphism and risk for amyotrophic lateral sclerosis

Siokas V., Karampinis E., Aloizou A.-M., Mentis A.-F.A., Liakos P., Papadimitriou D., Liampas I., Nasios G., Bogdanos D.P., Hadjigeorgiou G.M., Dardiotis E. (2021)

Background: Genetic variability is considered to confer susceptibility to amyotrophic lateral sclerosis (ALS). Oxidative stress is a significant contributor to ALS-related neurodegeneration, and it is regulated by cytochromes ...

Dna repair gene polymorphisms and susceptibility to urothelial carcinoma in a southeastern european population

Samara M., Papathanassiou M., Mitrakas L., Koukoulis G., Vlachostergios P.J., Tzortzis V. (2021)

Single nucleotide polymorphisms (SNPs) in DNA repair genes may predispose to urothelial carcinoma of the bladder (UCB). This study focused on three specific SNPs in a population with high exposure to environmental carcinogens ...

Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?

Zintzaras, E.; Stefanidis, I.; Santos, M.; Vidal, F. (2006)

Case-control studies that have investigated the association between alcoholism and alcohol-induced liver damage and the ADH2, ADH3, CYP2E1, and ADLH2 polymorphisms have reported controversial or inconclusive results. Thus, ...

Does the CD33 rs3865444 Polymorphism Confer Susceptibility to Alzheimer’s Disease?

Siokas V., Aslanidou P., Aloizou A.-M., Peristeri E., Stamati P., Liampas I., Arseniou S., Drakoulis N., Aschner M., Tsatsakis A., Mitsias P.D., Bogdanos D.P., Hadjigeorgiou G.M., Dardiotis E. (2020)

Alzheimer’s disease (AD) is a complex genetic disorder. To date, published data have reported conflicting results on the role of CD33 rs3865444 polymorphism in AD. The present study aimed at evaluating the effect of rs3865444 ...

Effect of integrin AV and B8 gene polymorphisms in patients with traumatic brain injury

Dardiotis E., Siokas V., Aloizou A.-M., Karampinis E., Brotis A.G., Grigoriadis S., Paterakis K., Dardioti M., Komnos A., Kapsalaki E., Fountas K., Hadjigeorgiou G.M. (2019)

Background: Α few genetic variants are associated with the outcome after traumatic brain injury (TBI). Integrins are glycoprotein receptors that play an important role in the integrity of microvasculature of the brain. ...

FCGR3A-V158F polymorphism is a disease-specific pharmacogenetic marker for the treatment of psoriasis with Fc-containing TNFα inhibitors

Mendrinou E., Patsatsi A., Zafiriou E., Papadopoulou D., Aggelou L., Sarri C., Mamuris Z., Kyriakou A., Sotiriadis D., Roussaki-Schulze A., Sarafidou T., Vasilopoulos Y. (2017)

Psoriasis is a multifactorial skin disease affecting ∼2% of world's population, causing a dramatic decrease in patients' quality of life and a significant increase in health-care expenses. Biological agents such as the ...

Frequency of resistance to benzimidazoles of Haemonchus contortus helminths from dairy sheep, goats, cattle and buffaloes in Greece

Arsenopoulos K., Minoudi S., Symeonidou I., Triantafyllidis A., Katsafadou A.I., Lianou D.T., Fthenakis G.C., Papadopoulos E. (2020)

The study investigated the presence of resistance to benzimidazoles in Haemonchus contortus helminths from ruminant species in Greece through the detection of the Phe/Tyr polymorphism in the amino acid at position 200 of ...

Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review

Tziastoudi M., Cholevas C., Stefanidis I., Theoharides T.C. (2022)

COVID-19 and ME/CFS present with some similar symptoms, especially physical and mental fatigue. In order to understand the basis of these similarities and the possibility of underlying common genetic components, we performed ...

Glutathione S-transferase gene polymorphism and asthma: A case-control study in a pediatric population

Kumar A., Ahmed T., Parvez M.K., Banerjee B.D., Maqusood M., Jagirdar R.M. (2022)

Aim: To carry out a case-control study of the association of GST gene polymorphisms in pediatric asthma-related oxidative stress. Materials & methods: Asthma patients (n = 250) and age-matched healthy subjects (n = 250) ...

Immune-Related Gene Polymorphisms and Pharmacogenetic Studies in Nephrology

Tziastoudi M., Cholevas C., Stefanidis I., Theoharides T.C. (2021)

A large subgroup of patients with chronic kidney disease still encounter serious adverse effects and lack of responsiveness to medications, possibly because of the interindividual genetic variability in genes involved in ...

Impact of renin–angiotensin–aldosterone system polymorphisms on myocardial perfusion: Correlations with myocardial single photon emission computed tomography-derived parameters

Angelidis G., Samara M., Papathanassiou M., Satra M., Valotassiou V., Tsougos I., Psimadas D., Tzavara C., Alexiou S., Koutsikos J., Demakopoulos N., Giamouzis G., Triposkiadis F., Skoularigis J., Kollia P., Georgoulias P. (2019)

Background: Renin–angiotensin–aldosterone system (RAAS) has an important role in atherosclerosis. We investigated the effects of six RAAS gene polymorphisms on myocardial perfusion. Methods and Results: We examined 810 ...

Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations

Meulenbelt, I.; Chapman, K.; Dieguez-Gonzalez, R.; Shi, D.; Tsezou, A.; Dai, J.; Malizos, K. N.; Kloppenburg, M.; Carr, A.; Nakajima, M.; van der Breggen, R.; Lakenberg, N.; Gomez-Reino, J. J.; Jiang, Q.; Ikegawa, S.; Gonzalez, A.; Loughlin, J.; Slagboom, E. P. (2009)

Recently, through a genome wide association study in Japanese knee osteoarthritis (OA) cases, a previously unknown gene, DVWA, was identified. The non-synonymous single nucleotide polymorphism (SNP) rs7639618 was subsequently ...