Πλοήγηση ανά Θέμα "Computational Biology"
Αποτελέσματα 1-20 από 40
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An automated blastomere identification method for the evaluation of day 2 embryos during IVF/ICSI treatments
(2018)Purpose Evaluation of human embryos is one of the most important challenges in vitro fertilization (IVF) programs. The morphology and the morphokinetic parameters of the early cleaving embryo are of critical clinical ... -
Bioinformatic Analysis of the BCL-xL/BCL2L1 Interactome in Patients with Pancreatic Cancer
(2022)Objectives: The aim of the present study was to analyze the differential gene expression of BCL-xL/BCL2L and the associated genetic, molecular, and biologic functions in pancreatic ductal adenocarcinoma (PDAC) by employing ... -
BUFET: Boosting the unbiased miRNA functional enrichment analysis using bitsets
(2017)Background: A group of miRNAs can regulate a biological process by targeting genes involved in the process. The unbiased miRNA functional enrichment analysis is the most precise in silico approach to predict the biological ... -
Cadherin and Wnt signaling pathways as key regulators in diabetic nephropathy
(2021)Aim A recent meta-analysis of genome-wide linkage studies (GWLS) has identified multiple genetic regions suggestive of linkage with DN harboring hundreds of genes. Moving this number of genetic loci forward into biological ... -
Combined prediction of Tat and Sec signal peptides with hidden Markov models
(2010)Motivation: Computational prediction of signal peptides is of great importance in computational biology. In addition to the general secretory pathway ( Sec), Bacteria, Archaea and chloroplasts possess another major pathway ... -
The complex evolutionary history of aminoacyl-tRNA synthetases
(2017)Aminoacyl-tRNA synthetases (AARSs) are a superfamily of enzymes responsible for the faithful translation of the genetic code and have lately become a prominent target for synthetic biologists. Our largescale analysis of > ... -
Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma
(2015)The aim of our study was to assess the differential gene expression of Parkinson protein 7 (PARK7) interactome in malignant pleural mesothelioma (MPM) using data mining techniques to identify novel candidate genes that may ... -
Delineation and interpretation of gene networks towards their effect in cellular physiology- a reverse engineering approach for the identification of critical molecular players, through the use of ontologies
(2010)Exploiting ontologies, provides clues regarding the involvement of certain molecular processes in the cellular phenotypic manifestation. However, identifying individual molecular actors (genes, proteins, etc.) for targeted ... -
DIANA-LncBase v3: Indexing experimentally supported miRNA targets on non-coding transcripts
(2020)DIANA-LncBase v3.0 (www.microrna.gr/LncBase) is a reference repository with experimentally supported miRNA targets on non-coding transcripts. Its third version provides approximately half a million entries, corresponding ... -
Diana-map: Analyzing mirna from raw ngs data to quantification
(2021)microRNAs (miRNAs) are small non-coding RNAs (~22 nts) that are considered central post-transcriptional regulators of gene expression and key components in many pathological conditions. Next-Generation Sequencing (NGS) ... -
DIANA-tarbase and DIANA suite tools: Studying experimentally supported microRNA targets
(2016)microRNAs (miRNAs) are short non-coding RNAs (~22 nts) present in animals, plants, and viruses. They are considered central post-transcriptional regulators of gene expression and are key components in a great number of ... -
Extending hidden Markov models to allow conditioning on previous observations
(2018)Hidden Markov Models (HMMs) are probabilistic models widely used in computational molecular biology. However, the Markovian assumption regarding transition probabilities which dictates that the observed symbol depends only ... -
ExTopoDB: a database of experimentally derived topological models of transmembrane proteins
(2010)ExTopoDB is a publicly accessible database of experimentally derived topological models of transmembrane proteins. It contains information collected from studies in the literature that report the use of biochemical methods ... -
Finding and analyzing plant metabolic gene clusters
(2012)Plants produce an array of diverse secondary metabolites with important ecological functions, providing protection against pests, diseases, and abiotic stresses. Secondary metabolites are also a rich source of bioactive ... -
gpDB: a database of GPCRs, G-proteins, effectors and their interactions
(2008)gpDB is a publicly accessible, relational database, containing information about G-proteins, G-protein coupled receptors (GPCRs) and effectors, as well as information concerning known interactions between these molecules. ... -
HEGESMA: genome search meta-analysis and heterogeneity testing
(2005)Heterogeneity and genome search meta-analysis (HEGESMA) is a comprehensive software for performing genome scan meta-analysis, a quantitative method to identify genetic regions (bins) with consistently increased linkage ... -
How Many 3D Structures Do We Need to Train a Predictor?
(2009)It has been shown that the progress in the determination of membrane protein structure grows exponentially, with approximately the same growth rate as that of the water-soluble proteins. In order to investigate the effect ... -
In-depth bioinformatic study of the cadherin 5 interactome in patients with thoracic aortic aneurysm unveils 8 novel biomarkers
(2022)OBJECTIVES: Thoracic aortic aneurysm (TAA) is characterized by the dilation of the aorta and is associated with poor prognosis if not diagnosed and treated early. In this context, the identification of biomarkers regarding ... -
In-depth bioinformatic study of the CLDN16 gene and protein: Prediction of subcellular localization to mitochondria
(2019)Background and Objectives: The defects in the CLDN16 gene are a cause of primary hypomagnesemia (FHHNC), which is characterized by massive renal magnesium wasting, resulting in nephrocalcinosis and renal failure. The ... -
Interleukin 21 controls mRNAand MicroRNA expression in CD40-activated chronic lymphocytic leukemia cells
(2015)Several factors support CLL cell survival in the microenvironment. Under different experimental conditions, IL21 can either induce apoptosis or promote CLL cell survival. To investigate mechanisms involved in the effects ...