• Anticoagulation after Stroke in Patients with Atrial Fibrillation: To Bridge or Not with Low-Molecular-Weight Heparin? 

      Altavilla R., Caso V., Bandini F., Agnelli G., Tsivgoulis G., Yaghi S., Furie K.L., Tadi P., Becattini C., Zedde M., Abdul-Rahim A.H., Lees K.R., Alberti A., Venti M., Acciarresi M., D'Amore C., Giulia Mosconi M., Anna Cimini L., Fusaro J., Bovi P., Carletti M., Rigatelli A., Cappellari M., Putaala J., Tomppo L., Tatlisumak T., Marcheselli S., Pezzini A., Poli L., Padovani A., Masotti L., Vannucchi V., Sohn S.-I., Lorenzini G., Tassi R., Guideri F., Acampa M., Martini G., Ntaios G., Athanasakis G., Makaritsis K., Karagkiozi E., Vadikolias K., Liantinioti C., Chondrogianni M., Mumoli N., Consoli D., Galati F., Sacco S., Carolei A., Tiseo C., Corea F., Ageno W., Bellesini M., Silvestrelli G., Ciccone A., Lanari A., Scoditti U., Denti L., Mancuso M., MacCarrone M., Ulivi L., Orlandi G., Giannini N., Gialdini G., Tassinari T., De Lodovici M.L., Bono G., Rueckert C., Baldi A., D'Anna S., Toni D., Letteri F., Giuntini M., Lotti E.M., Flomin Y., Pieroni A., Kargiotis O., Karapanayiotides T., Monaco S., Baronello M.M., Csiba L., Szabó L., Chiti A., Giorli E., Del Sette M., Imberti D., Zabzuni D., Doronin B., Volodina V., Michel P., Vanacker P., Barlinn K., Pallesen L.-P., Barlinn J., Deleu D., Melikyan G., Ibrahim F., Akhtar N., Gourbali V., Paciaroni M. (2019)
      Background and Purpose-Bridging therapy with low-molecular-weight heparin reportedly leads to a worse outcome for acute cardioembolic stroke patients because of a higher incidence of intracerebral bleeding. However, this ...
    • AQP4 tag SNPs in patients with intracerebral hemorrhage in Greek and Polish population 

      Dardiotis E., Siokas V., Marogianni C., Aloizou A.-M., Sokratous M., Paterakis K., Dardioti M., Grigoriadis S., Brotis A., Kapsalaki E., Fountas K., Jagiella J., Hadjigeorgiou G.M. (2019)
      Backround: A relatively small number of genetic variants are implicated to pathophysiology of intracerebral hemorrhage (ICH). Aquaporin-4 (AQP4) has been reported to be implicated in the pathophysiological processes of ICH ...
    • Clinical outcomes and neuroimaging profiles in nondisabled patients with anticoagulant-related intracerebral hemorrhage 

      Lioutas V.-A., Goyal N., Katsanos A.H., Krogias C., Zand R., Sharma V.K., Varelas P., Malhotra K., Paciaroni M., Sharaf A., Chang J., Karapanayiotides T., Kargiotis O., Pappa A., Mai J., Pandhi A., Schroeder C., Tsantes A., Mehta C., Kerro A., Khan A., Mitsias P.D., Selim M.H., Alexandrov A.V., Tsivgoulis G. (2018)
      Background and Purpose: The aim of this study was to prospectively validate our prior findings of smaller hematoma volume and lesser neurological deficit in nonvitamin K oral anticoagulant (NOAC) compared with Vitamin K ...
    • Direct oral anticoagulant-vs Vitamin K antagonist-related nontraumatic intracerebral hemorrhage 

      Tsivgoulis G., Lioutas V.-A., Varelas P., Katsanos A.H., Goyal N., Mikulik R., Barlinn K., Krogias C., Sharma V.K., Vadikolias K., Dardiotis E., Karapanayiotides T., Pappa A., Zompola C., Triantafyllou S., Kargiotis O., Ioakeimidis M., Giannopoulos S., Kerro A., Tsantes A., Mehta C., Jones M., Schroeder C., Norton C., Bonakis A., Chang J., Alexandrov A.W., Mitsias P., Alexandrov A.V. (2017)
      Objective: To compare the neuroimaging profile and clinical outcomes among patients with intracerebral hemorrhage (ICH) related to use of vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) for nonvalvular ...
    • Effect of integrin AV and B8 gene polymorphisms in patients with traumatic brain injury 

      Dardiotis E., Siokas V., Aloizou A.-M., Karampinis E., Brotis A.G., Grigoriadis S., Paterakis K., Dardioti M., Komnos A., Kapsalaki E., Fountas K., Hadjigeorgiou G.M. (2019)
      Background: Α few genetic variants are associated with the outcome after traumatic brain injury (TBI). Integrins are glycoprotein receptors that play an important role in the integrity of microvasculature of the brain. ...
    • External Validation of the Prestroke Independence, Sex, Age, National Institutes of Health Stroke Scale (ISAN) Score for Predicting Stroke-Associated Pneumonia in the Athens Stroke Registry 

      Papavasileiou V., Milionis H., Smith C.J., Makaritsis K., Bray B.D., Michel P., Manios E., Vemmos K., Ntaios G. (2015)
      Background and purpose The Prestroke Independence, Sex, Age, National Institutes of Health Stroke Scale (ISAN) score was developed recently for predicting stroke-associated pneumonia (SAP), one of the most common complications ...
    • Glyceryl trinitrate for acute intracerebral hemorrhage: Results from the Efficacy of Nitric Oxide in Stroke (ENOS) trial, a subgroup analysis 

      Krishnan K., Scutt P., Woodhouse L., Adami A., Becker J.L., Berge E., Cala L.A., Casado A.M., Caso V., Chen C., Christensen H., Collins R., Czlonkowska A., Dineen R.A., Gommans J., Koumellis P., Lees K.R., Ntaios G., Ozturk S., Phillips S.J., Pocock S.J., De Silva A., Sprigg N., Szatmari S., Wardlaw J.M., Bath P.M. (2016)
      Background and Purpose - The Efficacy of Nitric Oxide in Stroke (ENOS) trial found that transdermal glyceryl trinitrate (GTN, a nitric oxide donor) lowered blood pressure but did not improve functional outcome in patients ...
    • Hemorrhagic transformation in patients with acute ischemic stroke and atrial fibrillation: Time to initiation of oral anticoagulant therapy and outcomes 

      Paciaroni M., Bandini F., Agnelli G., Tsivgoulis G., Yaghi S., Furie K.L., Tadi P., Becattini C., Zedde M., Abdul-Rahim A.H., Lees K.R., Alberti A., Venti M., Acciarresi M., D’Amore C., Mosconi M.G., Cimini L.A., Altavilla R., Volpi G., Bovi P., Carletti M., Rigatelli A., Cappellari M., Putaala J., Tomppo L., Tatlisumak T., Marcheselli S., Pezzini A., Poli L., Padovani A., Masotti L., Vannucchi V., Sohn S.-I., Lorenzini G., Tassi R., Guideri F., Acampa M., Martini G., Ntaios G., Athanasakis G., Makaritsis K., Karagkiozi E., Vadikolias K., Liantinioti C., Chondrogianni M., Mumoli N., Consoli D., Galati F., Sacco S., Carolei A., Tiseo C., Corea F., Ageno W., Bellesini M., Colombo G., Silvestrelli G., Ciccone A., Lanari A., Scoditti U., Denti L., Mancuso M., Maccarrone M., Ulivi L., Orlandi G., Giannini N., Gialdini G., Tassinari T., De Lodovici M.L., Bono G., Rueckert C., Baldi A., D'Anna S., Toni D., Letteri F., Giuntini M., Lotti E.M., Flomin Y., Pieroni A., Kargiotis O., Karapanayiotides T., Monaco S., Baronello M.M., Csiba L., Szabó L., Chiti A., Giorli E., Del Sette M., Imberti D., Zabzuni D., Doronin B., Volodina V., Michel P., Vanacker P., Barlinn K., Pallesen L.-P., Barlinn J., Deleu D., Melikyan G., Ibrahim F., Akhtar N., Gourbali V., Caso V. (2018)
      Background—In patients with acute ischemic stroke and atrial fibrillation, early anticoagulation prevents ischemic recurrence but with the risk of hemorrhagic transformation (HT). The aims of this study were to evaluate ...
    • Integrins AV and B8 Gene Polymorphisms and Risk for Intracerebral Hemorrhage in Greek and Polish Populations 

      Dardiotis E., Siokas V., Zafeiridis T., Paterakis K., Tsivgoulis G., Dardioti M., Grigoriadis S., Simeonidou C., Deretzi G., Zintzaras E., Jagiella J., Hadjigeorgiou G.M. (2017)
      Α limited number of genetic variants have been linked to the development of intracerebral hemorrhage (ICH). Ιntegrin AV and/or B8-deficient mice were found to develop ICH. The present candidate gene association study was ...
    • Microbleeds and the Effect of Anticoagulation in Patients with Embolic Stroke of Undetermined Source: An Exploratory Analysis of the NAVIGATE ESUS Randomized Clinical Trial 

      Shoamanesh A., Hart R.G., Connolly S.J., Kasner S.E., Smith E.E., Martí-Fàbregas J., Liu Y.Y., Uchiyama S., Mikulik R., Veltkamp R., O'Donnell M.J., Ntaios G., Muir K.W., Field T.S., Santo G.C., Olavarria V., Mundl H., Lutsep H., Berkowitz S.D., Sharma M. (2021)
      Importance: The reported associations of cerebral microbleeds with recurrent stroke and intracerebral hemorrhage have raised concerns regarding antithrombotic treatment in patients with a history of stroke and microbleeds ...
    • Neuroimaging and clinical outcomes of oral anticoagulant–associated intracerebral hemorrhage 

      Tsivgoulis G., Wilson D., Katsanos A.H., Sargento-Freitas J., Marques-Matos C., Azevedo E., Adachi T., von der Brelie C., Aizawa Y., Abe H., Tomita H., Okumura K., Hagii J., Seiffge D.J., Lioutas V.-A., Traenka C., Varelas P., Basir G., Krogias C., Purrucker J.C., Sharma V.K., Rizos T., Mikulik R., Sobowale O.A., Barlinn K., Sallinen H., Goyal N., Yeh S.-J., Karapanayiotides T., Wu T.Y., Vadikolias K., Ferrigno M., Hadjigeorgiou G., Houben R., Giannopoulos S., Schreuder F.H.B.M., Chang J.J., Perry L.A., Mehdorn M., Marto J.-P., Pinho J., Tanaka J., Boulanger M., Salman R.A.-S., Jäger H.R., Shakeshaft C., Yakushiji Y., Choi P.M.C., Staals J., Cordonnier C., Jeng J.-S., Veltkamp R., Dowlatshahi D., Engelter S.T., Parry-Jones A.R., Meretoja A., Mitsias P.D., Alexandrov A.V., Ambler G., Werring D.J. (2018)
      Objective: Whether intracerebral hemorrhage (ICH) associated with non–vitamin K antagonist oral anticoagulants (NOAC-ICH) has a better outcome compared to ICH associated with vitamin K antagonists (VKA-ICH) is uncertain. ...
    • The prognostic utility of ICH-score in anticoagulant related intracerebral hemorrhage 

      Katsanos A.H., Krogias C., Lioutas V.-A., Goyal N., Zand R., Sharma V.K., Varelas P., Malhotra K., Paciaroni M., Sharaf A., Chang J., Karapanayiotides T., Kargiotis O., Pappa A., Mai J., Tsantes A., Boviatsis E., Lambadiari V., Shoamanesh A., Mitsias P.D., Selim M.H., Alexandrov A.V., Tsivgoulis G. (2020)
      Although intracerebral hemorrhage (ICH) score is used to provide an estimate on the probability of mortality following spontaneous ICH of any cause, its utility has not been exclusively tested in ICH patients with history ...
    • Risk Factors for Intracerebral Hemorrhage in Patients with Atrial Fibrillation on Non-Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention 

      Paciaroni M., Agnelli G., Giustozzi M., Caso V., Toso E., Angelini F., Canavero I., Micieli G., Antonenko K., Rocco A., Diomedi M., Katsanos A.H., Shoamanesh A., Giannopoulos S., Ageno W., Pegoraro S., Putaala J., Strbian D., Sallinen H., Mac Grory B.C., Furie K.L., Stretz C., Reznik M.E., Alberti A., Venti M., Mosconi M.G., Vedovati M.C., Franco L., Zepponi G., Romoli M., Zini A., Brancaleoni L., Riva L., Silvestrelli G., Ciccone A., Zedde M.L., Giorli E., Kosmidou M., Ntais E., Palaiodimou L., Halvatsiotis P., Tassinari T., Saia V., Ornello R., Sacco S., Bandini F., Mancuso M., Orlandi G., Ferrari E., Pezzini A., Poli L., Cappellari M., Forlivesi S., Rigatelli A., Yaghi S., Scher E., Frontera J.A., Masotti L., Grifoni E., Caliandro P., Zauli A., Reale G., Marcheselli S., Gasparro A., Terruso V., Arnao V., Aridon P., Abdul-Rahim A.H., Dawson J., Saggese C.E., Palmerini F., Doronin B., Volodina V., Toni D., Risitano A., Schirinzi E., Del Sette M., Lochner P., Monaco S., Mannino M., Tassi R., Guideri F., Acampa M., Martini G., Lotti E.M., Padroni M., Pantoni L., Rosa S., Bertora P., Ntaios G., Sagris D., Baldi A., D'Amore C., Mumoli N., Porta C., Denti L., Chiti A., Corea F., Acciarresi M., Flomin Y., Popovic N., Tsivgoulis G. (2021)
      Background and Purpose: Clinical trials on stroke prevention in patients with atrial fibrillation have consistently shown clinical benefit from either warfarin or non-vitamin K antagonist oral anticoagulants (NOACs). ...