Πλοήγηση ανά Θέμα "American Chemical Society"
Αποτελέσματα 1-20 από 24
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Affinity Crystallography Reveals Binding of Pomegranate Juice Anthocyanins at the Inhibitor Site of Glycogen Phosphorylase: The Contribution of a Sugar Moiety to Potency and Its Implications to the Binding Mode
(2020)Anthocyanins (ACNs) are dietary phytochemicals with an acknowledged therapeutic significance. Pomegranate juice (PJ) is a rich source of ACNs with potential applications in nutraceutical development. Glycogen phosphorylase ... -
Anion-Cation Double Doped Co3O4 Microtube Architecture to Promote High-Valence Co Species Formation for Enhanced Oxygen Evolution Reaction
(2019)A method for efficiently catalyzing the oxygen evolution reaction (OER) represents a top priority for water electrolysis due to its multistep electron transfer pathway and sluggish kinetics. The OER activity can be promoted ... -
Approaching Highly Leaching-Resistant Fire-Retardant Wood by in Situ Polymerization with Melamine Formaldehyde Resin
(2021)The objective of the work was to improve the leaching resistance of fire-retardant (FR) modified wood by the incorporation of a thermoset resin. Here, Scots pine (Pinus sylvestris L.) sapwood was impregnated with melamine ... -
Atomic Scale Mechanisms of Multimode Oxide Growth on Nickel-Chromium Alloy: Direct in Situ Observation of the Initial Oxide Nucleation and Growth
(2021)The initial growth mode of oxide on alloy plays a decisive role in the development of protective oxide scales on metals and alloys, which is critical for their functionality for high temperature applications. However, the ... -
A Computational Strategy for the Design of Photochromic Derivatives Based on Diarylethene and Nickel Dithiolene with Large Contrast in Nonlinear Optical Properties
(2020)We designed a series of photochromic derivatives by employing density functional method (CAM-B3LYP/6-31G*). These compounds are based on DAE (diarylethenes), both sides of which are bonded with benzene and NiBDT ... -
Design and Synthesis of Highly Performing Bifunctional Ni-NiO-MoNi Hybrid Catalysts for Enhanced Urea Oxidation and Hydrogen Evolution Reactions
(2020)In order to provide solutions for the pollution caused by nitrogen-containing wastewater and the shortage of fossil fuels, it is urgent to design highly performing bifunctional catalysts for the urea oxidation reaction ... -
Design and Synthesis of Type-IV Inhibitors of BRAF Kinase That Block Dimerization and Overcome Paradoxical MEK/ERK Activation
(2019)Despite the clinical success of BRAF inhibitors like vemurafenib in treating metastatic melanoma, resistance has emerged through "paradoxical MEK/ERK signaling" where transactivation of one protomer occurs as a result of ... -
Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-κB Ligand with a Superior Therapeutic Index
(2020)Receptor activator of nuclear factor-κB ligand (RANKL) constitutes the master mediator of osteoclastogenesis, while its pharmaceutical inhibition by a monoclonal antibody has been approved for the treatment of postmenopausal ... -
Electrochemical Approach for Analyzing Electrolyte Transport Properties and Their Effect on Protonic Ceramic Fuel Cell Performance
(2017)The design and development of highly conductive materials with wide electrolytic domain boundaries are among the most promising means of enabling solid oxide fuel cells (SOFCs) to demonstrate outstanding performance across ... -
Enhanced Ultrasonic-Assisted Heterogeneous Fenton Degradation of Organic Pollutants over a New Copper Magnetite (Cu-Fe3O4/Cu/C) Nanohybrid Catalyst
(2020)A copper magnetite nanohybrid catalyst (Cu-Fe3O4/Cu/C), abundant of Schottky interfaces and structural defects, with ultrathin encapsulation of graphitic carbon, was synthesized and tested. The catalyst shows enhanced ... -
Framework for Design under Uncertainty Including Inherent Safety, Environmental Assessment, and Economic Performance of Chemical Processes
(2019)Typically, analysis and design of chemical processes is carried out considering average values of inherently uncertain data that pertain to key design and process variables that shape its performance. In this work, a ... -
Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography
(2019)Epimeric series of aryl-substituted glucopyranosylidene-spiro-imidazolinones, an unprecedented new ring system, were synthesized from the corresponding Schiff bases of O-perbenzoylated (gluculopyranosylamine)onamides by ... -
Landscape of Eukaryotic Transmembrane Beta Barrel Proteins
(2020)Even though in the last few years several families of eukaryotic β-barrel outer membrane proteins have been discovered, their computational characterization and their annotation in public databases are far from complete. ... -
Multifunctional Polymeric Platform of Magnetic Ferrite Colloidal Superparticles for Luminescence, Imaging, and Hyperthermia Applications
(2016)Adequately designed multiresponsive water-soluble graft copolymers were used to serve as a multifunctional polymeric platform for the encapsulation and transfer in aqueous media of hydrophobic magnetic nanoparticles (MNPs). ... -
Nanomolar Inhibitors of Glycogen Phosphorylase Based on β- D -Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study
(2017)Aryl substituted 1-(β-d-glucosaminyl)-1,2,3-triazoles as well as C-β-d-glucosaminyl 1,2,4-triazoles and imidazoles were synthesized and tested as inhibitors against muscle and liver isoforms of glycogen phosphorylase (GP). ... -
Novel Bifunctional V2O3Nanosheets Coupled with N-Doped-Carbon Encapsulated Ni Heterostructure for Enhanced Electrocatalytic Oxidation of Urea-Rich Wastewater
(2020)Developing high performance bifunctional transition metal catalysts would be significantly beneficial for electrocatalytic oxidation of urea-rich wastewater. Herein, we synthesize a V2O3 nanosheet anchored N-doped-carbon ... -
Novel Mn-/Co-N x Moieties Captured in N-Doped Carbon Nanotubes for Enhanced Oxygen Reduction Activity and Stability in Acidic and Alkaline Media
(2021)Fe-N-C-based electrocatalysts have been developed as an encouraging substitute compared to their expensive Pt-containing equivalents for the oxygen reduction reaction (ORR). However, they still face major durability ... -
Optimization of Recombinant Membrane Protein Production in the Engineered Escherichia coli Strains SuptoxD and SuptoxR
(2019)Membrane proteins (MPs) execute a wide variety of critical biological functions in all living organisms and constitute approximately half of current targets for drug discovery. As in the case of soluble proteins, the ... -
Oxygen Reduction Reaction over PtFeM (M = Mo, V, W) Alloy Electrocatalysts: Role of the Compressive Strain Effect on Pt
(2019)The high level loading requirement of platinum and the sluggish oxygen reduction kinetics - catalyzed by platinum-based electrocatalysts - create major bottlenecks for cost-effective application of fuel cell technology. ... -
Proteomic analysis of human angiogenin interactions reveals cytoplasmic PCNA as a putative binding partner
(2017)Human Angiogenin (hAng) is a member of the ribonuclease A superfamily and a potent inducer of neovascularization. Protein interactions of hAng in the nucleus and cytoplasm of the human umbilical vein cell line EA.hy926 ...