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Πλοήγηση ανά Θέμα "Alzheimer Disease"

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    • Analysis of ADORA2A rs5760423 and CYP1A2 rs762551 Genetic Variants in Patients with Alzheimer’s Disease 

      Siokas V., Mouliou D.S., Liampas I., Aloizou A.-M., Folia V., Zoupa E., Papadimitriou A., Lavdas E., Bogdanos D.P., Dardiotis E. (2022)
      Various studies have been conducted, exploring the genetic susceptibility of Alzheimer’s disease (AD). Adenosine receptor subtype A2a (ADORA2A) and cytochrome P450 1A2 (CYP1A2) are implicated in pathways such as oxidative ...

    • Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework 

      Mentis A.-F.A., Dardiotis E., Chrousos G.P. (2021)
      The potential existence and roles of the meningeal lymphatic system in normal and pathological brain function have been a long-standing enigma. Recent evidence suggests that meningeal lymphatic vessels are present in both ...

    • Applications of nanotechnology in diagnostics and therapeutics of Alzheimer's and Parkinson's disease 

      Soursou G., Alexiou A., Ashraf G.M., Siyal A.A., Mushtaq G., Kamal M.A. (2015)
      In this paper, an extended review analysis has been presented concerning the developments in brain drug delivery through new and efficient applications of nanotechnology. Modern nanotechnological approaches for the diagnosis ...

    • Association between 9p21–23 Locus and Frailty in a Community-Dwelling Greek Population: Results from the Hellenic Longitudinal Investigation of Ageing and Diet 

      Mourtzi N., Hatzimanolis A., Xiromerisiou G., Ntanasi E., Georgakis M.K., Ramirez A., Heilmann-Heimbach S., Grenier-Boley B., Lambert J.C., Yannakoulia M., Kosmidis M., Dardiotis E., Hadjigeorgiou G., Sakka P., Scarmeas N. (2022)
      Background: Frailty is a complex geriatric syndrome arising from a combination of genetic and environmental factors and is associated with adverse health outcomes and mortality. A recent study reported an association between ...

    • Atrial Fibrillation Is Associated with Cognitive Impairment, All-Cause Dementia, Vascular Dementia, and Alzheimer’s Disease: a Systematic Review and Meta-Analysis 

      Papanastasiou C.A., Theochari C.A., Zareifopoulos N., Arfaras-Melainis A., Giannakoulas G., Karamitsos T.D., Palaiodimos L., Ntaios G., Avgerinos K.I., Kapogiannis D., Kokkinidis D.G. (2021)
      Background: Atrial fibrillation (AF) is a risk factor for cognitive impairment and dementia in patients with stroke history. However, the association between AF and cognitive impairment in broader populations is less clear. ...

    • Beneficial Effect of Multidomain Cognitive Training on the Neuropsychological Performance of Patients with Early-Stage Alzheimer's Disease 

      Nousia A., Siokas V., Aretouli E., Messinis L., Aloizou A.-M., Martzoukou M., Karala M., Koumpoulis C., Nasios G., Dardiotis E. (2018)
      Background and Purpose. There is an increasing interest in the effect of nonpharmacological interventions on the course of patients with Alzheimer's disease (AD). The objective of the present study is to determine the ...

    • Biomarkers for Alzheimer’s disease diagnosis 

      Mantzavinos V., Alexiou A. (2017)
      Objective: The dramatic increase in the population with dementia expected in the next decades is accompanied by the establishment of novel and innovated methods that will offer accurate and efficient detection of the disease ...

    • Care of Patients with Alzheimer’s Disease 

      Athanasiadou E., Tsaloglidou A., Koukourikos K., Papathanasiou I.V., Iliadis C.H., Frantzana A., Fradelos E., Kourkouta L. (2021)
      Introduction: Alzheimer’s disease is one of the irreversible dementias and leads to death. About 10% of people over 60 years and 20% of people over 80 will have Alzheimer’s sometime in their lives. In the case of Alzheimer’s ...

    • Comment on rosell-cardona et al. Dietary spray-dried porcine plasma reduces neuropathological alzheimer’s disease hallmarks in samp8 mice. nutrients 2021, 13, 2369 

      Nifli A.-P. (2021)
      [No abstract available]

    • Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores 

      de Rojas I., Moreno-Grau S., Tesi N., Grenier-Boley B., Andrade V., Jansen I.E., Pedersen N.L., Stringa N., Zettergren A., Hernández I., Montrreal L., Antúnez C., Antonell A., Tankard R.M., Bis J.C., Sims R., Bellenguez C., Quintela I., González-Perez A., Calero M., Franco-Macías E., Macías J., Blesa R., Cervera-Carles L., Menéndez-González M., Frank-García A., Royo J.L., Moreno F., Huerto Vilas R., Baquero M., Diez-Fairen M., Lage C., García-Madrona S., García-González P., Alarcón-Martín E., Valero S., Sotolongo-Grau O., Ullgren A., Naj A.C., Lemstra A.W., Benaque A., Pérez-Cordón A., Benussi A., Rábano A., Padovani A., Squassina A., de Mendonça A., Arias Pastor A., Kok A.A.L., Meggy A., Pastor A.B., Espinosa A., Corma-Gómez A., Martín Montes A., Sanabria Á., DeStefano A.L., Schneider A., Haapasalo A., Kinhult Ståhlbom A., Tybjærg-Hansen A., Hartmann A.M., Spottke A., Corbatón-Anchuelo A., Rongve A., Borroni B., Arosio B., Nacmias B., Nordestgaard B.G., Kunkle B.W., Charbonnier C., Abdelnour C., Masullo C., Martínez Rodríguez C., Muñoz-Fernandez C., Dufouil C., Graff C., Ferreira C.B., Chillotti C., Reynolds C.A., Fenoglio C., Van Broeckhoven C., Clark C., Pisanu C., Satizabal C.L., Holmes C., Buiza-Rueda D., Aarsland D., Rujescu D., Alcolea D., Galimberti D., Wallon D., Seripa D., Grünblatt E., Dardiotis E., Düzel E., Scarpini E., Conti E., Rubino E., Gelpi E., Rodriguez-Rodriguez E., Duron E., Boerwinkle E., Ferri E., Tagliavini F., Küçükali F., Pasquier F., Sanchez-Garcia F., Mangialasche F., Jessen F., Nicolas G., Selbæk G., Ortega G., Chêne G., Hadjigeorgiou G., Rossi G., Spalletta G., Giaccone G., Grande G., Binetti G., Papenberg G., Hampel H., Bailly H., Zetterberg H., Soininen H., Karlsson I.K., Alvarez I., Appollonio I., Giegling I., Skoog I., Saltvedt I., Rainero I., Rosas Allende I., Hort J., Diehl-Schmid J., Van Dongen J., Vidal J.-S., Lehtisalo J., Wiltfang J., Thomassen J.Q., Kornhuber J., Haines J.L., Vogelgsang J., Pineda J.A., Fortea J., Popp J., Deckert J., Buerger K., Morgan K., Fließbach K., Sleegers K., Molina-Porcel L., Kilander L., Weinhold L., Farrer L.A., Wang L.-S., Kleineidam L., Farotti L., Parnetti L., Tremolizzo L., Hausner L., Benussi L., Froelich L., Ikram M.A., Deniz-Naranjo M.C., Tsolaki M., Rosende-Roca M., Löwenmark M., Hulsman M., Spallazzi M., Pericak-Vance M.A., Esiri M., Bernal Sánchez-Arjona M., Dalmasso M.C., Martínez-Larrad M.T., Arcaro M., Nöthen M.M., Fernández-Fuertes M., Dichgans M., Ingelsson M., Herrmann M.J., Scherer M., Vyhnalek M., Kosmidis M.H., Yannakoulia M., Schmid M., Ewers M., Heneka M.T., Wagner M., Scamosci M., Kivipelto M., Hiltunen M., Zulaica M., Alegret M., Fornage M., Roberto N., van Schoor N.M., Seidu N.M., Banaj N., Armstrong N.J., Scarmeas N., Scherbaum N., Goldhardt O., Hanon O., Peters O., Skrobot O.A., Quenez O., Lerch O., Bossù P., Caffarra P., Dionigi Rossi P., Sakka P., Hoffmann P., Holmans P.A., Fischer P., Riederer P., Yang Q., Marshall R., Kalaria R.N., Mayeux R., Vandenberghe R., Cecchetti R., Ghidoni R., Frikke-Schmidt R., Sorbi S., Hägg S., Engelborghs S., Helisalmi S., Botne Sando S., Kern S., Archetti S., Boschi S., Fostinelli S., Gil S., Mendoza S., Mead S., Ciccone S., Djurovic S., Heilmann-Heimbach S., Riedel-Heller S., Kuulasmaa T., del Ser T., Lebouvier T., Polak T., Ngandu T., Grimmer T., Bessi V., Escott-Price V., Giedraitis V., Deramecourt V., Maier W., Jian X., Pijnenburg Y.A.L., Smith A.D., Saenz A., Bizzarro A., Lauria A., Vacca A., Solomon A., Anastasiou A., Richardson A., Boland A., Koivisto A., Daniele A., Greco A., Marianthi A., McGuinness B., Fin B., Ferrari C., Custodero C., Ferrarese C., Ingino C., Mangone C., Reyes Toso C., Martínez C., Cuesta C., Muchnik C., Joachim C., Ortiz C., Besse C., Johansson C., Zoia C.P., Laske C., Anastasiou C., Palacio D.L., Politis D.G., Janowitz D., Craig D., Mann D.M., Neary D., Jürgen D., Daian D., Belezhanska D., Kohler E., Castaño E.M., Koutsouraki E., Chipi E., De Roeck E., Costantini E., Vardy E.R.L.C., Piras F., Roveta F., Piras F., Prestia F.A., Assogna F., Salani F., Sala G., Lacidogna G., Novack G., Wilcock G., Thonberg H., Kölsch H., Weber H., Boecker H., Etchepareborda I., Piaceri I., Tuomilehto J., Lindström J., Laczo J., Johnston J., Deleuze J.-F., Harris J., Schott J.M., Priller J., Bacha J.I., Snowden J., Lisso J., Mihova K.Y., Traykov L., Morelli L., Brusco L.I., Rainer M., Takalo M., Bjerke M., Del Zompo M., Serpente M., Sanchez Abalos M., Rios M., Peltonen M., Herrman M.J., Kosmidis M.H., Kohler M., Rojo M., Jones M., Orsini M., Medel N., Olivar N., Fox N.C., Salvadori N., Hooper N.M., Galeano P., Solis P., Bastiani P., Mecocci P., Passmore P., Heun R., Antikainen R., Olaso R., Perneczky R., Germani S., López-García S., Love S., Mehrabian S., Bagnoli S., Kochen S., Andreoni S., Teipel S., Todd S., Pickering-Brown S., Natunen T., Tegos T., Laatikainen T., Strandberg T., Polvikoski T.M., Matoska V., Ciullo V., Cores V., Solfrizzi V., Lisetti V., Sevillano Z., Abdelnour C., Aguilera N., Alarcon E., Alegret M., Benaque A., Boada M., Buendia M., Cañabate P., Carracedo A., Corbatón-Anchuelo A., Diego S., Espinosa A., Gailhajenet A., Gil S., Guitart M., Hernández I., Ibarria M., Lafuente A., Macias J., Maroñas O., Martín E., Martínez M.T., Marquié M., Mauleón A., Montrreal L., Moreno-Grau S., Moreno M., Orellana A., Ortega G., Pancho A., Pelejá E., Pérez-Cordon A., Preckler S., Quintela I., Real L.M., Rosende-Roca M., Ruiz A., Sáez M.E., Sanabria A., Serrano-Rios M., Sotolongo-Grau O., Tárraga L., Valero S., Vargas L., Adarmes-Gómez A.D., Alarcón-Martín E., Alonso M.D., Álvarez I., Álvarez V., Amer-Ferrer G., Antequera M., Antúnez C., Baquero M., Bernal M., Blesa R., Boada M., Buiza-Rueda D., Bullido M.J., Burguera J.A., Calero M., Carrillo F., Carrión-Claro M., Casajeros M.J., Clarimón J., Cruz-Gamero J.M., de Pancorbo M.M., del Ser T., Diez-Fairen M., Escuela R., Garrote-Espina L., Fortea J., Franco-Macías E., Frank-García A., García-Alberca J.M., Garcia Madrona S., Garcia-Ribas G., Gómez-Garre P., Hernández I., Hevilla S., Jesús S., Labrador Espinosa M.A., Lage C., Legaz A., Lleó A., Lopez de Munain A., López-García S., Macias-García D., Manzanares S., Marín M., Marín-Muñoz J., Marín T., Marquié M., Martín Montes A., Martínez B., Martínez C., Martínez V., Martínez-Lage Álvarez P., Medina M., Mendioroz Iriarte M., Mir P., Molinuevo J.L., Pastor P., Pérez-Tur J., Periñán-Tocino T., Pineda-Sanchez R., Piñol-Ripoll G., Rábano A., Real de Asúa D., Rodrigo S., Rodríguez-Rodríguez E., Royo J.L., Ruiz A., Sanchez del Valle Díaz R., Sánchez-Juan P., Sastre I., Valero S., Vicente M.P., Vigo-Ortega R., Vivancos L., Macleod C., McCracken C., Brayne C., Bresner C., Grozeva D., Bellou E., Sommerville E.W., Matthews F., Leonenko G., Menzies G., Windle G., Harwood J., Phillips J., Bennett K., Luckuck L., Clare L., Woods R., Saad S., Burholt V., Jansen I.E., Rongve A., Kehoe P.G., Garcia-Ribas G., Sánchez-Juan P., Pastor P., Lopez de Munain A., García-Alberca J.M., Bullido M.J., Álvarez V., Real L.M., Scheltens P., Holstege H., Marquié M., Sáez M.E., Amouyel P., Schellenberg G.D., Williams J., Seshadri S., van Duijn C.M., Mather K.A., Sánchez-Valle R., Serrano-Ríos M., Orellana A., Tárraga L., Blennow K., Huisman M., Andreassen O.A., Posthuma D., Clarimón J., Boada M., van der Flier W.M., Ramirez A., Lambert J.-C., van der Lee S.J., Ruiz A., EADB contributors, The GR@ACE study group, DEGESCO consortium, IGAP (ADGC, CHARGE, EADI, GERAD), PGC-ALZ consortia (2021)
      Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical ...

    • Confidence intervals for differences between volumes under receiver operating characteristic surfaces (VUS) and generalized Youden indices (GYIs) 

      Yin J., Nakas C.T., Tian L., Reiser B. (2018)
      This article explores both existing and new methods for the construction of confidence intervals for differences of indices of diagnostic accuracy of competing pairs of biomarkers in three-class classification problems and ...

    • Correlation of Neuropsychiatric Symptoms in Dementia with Brain Perfu-sion: A 99mTc-SPECT-HMPAO Study with Brodmann Areas Analysis 

      Valotassiou V., Sifakis N., Tzavara C., Lykou E., Tsinia N., Kamtsadeli V., Sali D., Angelidis G., Psimadas D., Tsougos I., Papageorgiou S.G., Georgoulias P., Papatriantafyllou J. (2021)
      Background: Neuropsychiatric symptoms (NPSs) are common in dementia. Their evaluation is based on Neuropsychiatric Inventory (NPI). Neuroimaging studies have tried to elucidate the underlying neural circuits either in ...

    • Differences of apathy perfusion correlates between Alzheimer’s disease and frontotemporal dementia. A 99mTc-HMPAO SPECT study with automated Brodmann areas analysis 

      Valotassiou V., Sifakis N., Tzavara C., Lykou E., Tsinia N., Kamtsadeli V., Sali D., Angelidis G., Psimadas D., Tsougos I., Papageorgiou S.G., Georgoulias P., Papatriantafyllou J. (2022)
      Objectives: To explore differences of apathy perfusion correlates between Alzheimer’s disease (AD) and Frontotemporal dementia (FTD) using perfusion SPECT. Methods: We studied 75 FTD and 66 AD patients. We evaluated apathy ...

    • Differential effects of completed and incomplete pregnancies on the risk of Alzheimer disease 

      Jang H., Bae J.B., Dardiotis E., Scarmeas N., Sachdev P.S., Lipnicki D.M., Han J.W., Kim T.H., Kwak K.P., Kim B.J., Kim S.G., Kim J.L., Moon S.W., Park J.H., Ryu S.-H., Youn J.C., Lee D.Y., Lee D.W., Lee S.B., Lee J.J., Jhoo J.H., Yannakoulia M., Kosmidis M.H., Hadjigeorgiou G.M., Sakka P., Kim K.W. (2018)
      Objective To investigate the effects of completed pregnancy with childbirth and incomplete pregnancy without childbirth on the late-life cognition and the risk of Alzheimer disease (AD) in women. Methods Using the pooled ...

    • Does SCFD1 rs10139154 Polymorphism Decrease Alzheimer’s Disease Risk? 

      Stamati P., Siokas V., Aloizou A.-M., Karampinis E., Arseniou S., Rakitskii V.N., Tsatsakis A., Spandidos D.A., Gozes I., Mitsias P.D., Bogdanos D.P., Hadjigeorgiou G.M., Dardiotis E. (2019)
      Α number of genetic variants have been associated with Alzheimer’s disease (AD) susceptibility. Sec1 family domain-containing protein 1 (SCFD1) gene polymorphism rs10139154 has recently been implicated in the risk of ...

    • Does the CD33 rs3865444 Polymorphism Confer Susceptibility to Alzheimer’s Disease? 

      Siokas V., Aslanidou P., Aloizou A.-M., Peristeri E., Stamati P., Liampas I., Arseniou S., Drakoulis N., Aschner M., Tsatsakis A., Mitsias P.D., Bogdanos D.P., Hadjigeorgiou G.M., Dardiotis E. (2020)
      Alzheimer’s disease (AD) is a complex genetic disorder. To date, published data have reported conflicting results on the role of CD33 rs3865444 polymorphism in AD. The present study aimed at evaluating the effect of rs3865444 ...

    • Double hit viral parasitism, polymicrobial CNS residency and perturbed proteostasis in Alzheimer's disease: A data driven, in silico analysis of gene expression data 

      Vavougios G.D., Nday C., Pelidou S.-H., Zarogiannis S.G., Gourgoulianis K.I., Stamoulis G., Doskas T. (2020)
      The aim of this study was to determine the interaction of peripheral immunity vs. the CNS in the setting of AD pathogenesis at the transcriptomic level in a data driven manner. For this purpose, publicly available gene ...

    • Eating Disorders in Frontotemporal Dementia and Alzheimer's Disease: Evaluation of Brain Perfusion Correlates Using 99mTc-HMPAO SPECT with Brodmann Areas Analysis 

      Valotassiou V., Sifakis N., Tzavara C., Lykou E., Tsinia N., Kamtsadeli V., Sali D., Angelidis G., Psimadas D., Tsougos I., Papageorgiou S.G., Georgoulias P., Papatriantafyllou J. (2021)
      Background: Eating disorders (ED) in dementia represent a significant impairment affecting patients' and caregivers' lives. In frontotemporal dementia (FTD), ED include overeating, sweet food preference, stereotypical ...

    • Evaluation of memory performance in patients with brain disorders following rTMS treatment. A systematic review 

      Bonotis K., Anargyros K., Liaskopoulos N., Barlogianni A.-M. (2022)
      Objective: Repetitive transcranial magnetic stimulation (rTMS) is being used as a non-invasive, non-pharmacological treatment with emerging clinical applications. The objective of this systematic review is to assess the ...

    • Fish intake, n-3 fatty acid body status, and risk of cognitive decline: a systematic review and a dose-response meta-analysis of observational and experimental studies 

      Kosti R.I., Kasdagli M.I., Kyrozis A., Orsini N., Lagiou P., Taiganidou F., Naska A. (2022)
      Context: Randomized controlled trials (RCTs) testing supplementation with eicosapentaenoic (EPA) and docosahexaenoic (DHA) fatty acids have failed to provide evidence supporting a suggested inverse association between fish ...